Rap1gap MGI Mouse Gene Detail - MGI:109338 - Rap1 GTPase-activating protein

Symbol

Rap1gap
Name

Rap1 GTPase-activating protein
Synonyms

1300019I11Rik, 2310004O14Rik, Gap, Rap1ga1

Feature Type

protein coding gene
IDs

MGI:109338
NCBI Gene: 110351
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr4:137392037-137457172 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 70.02 cM, cytoband D3
Mapping Data

4 experiments

SNPs within 2kb

3571 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109338	protein coding gene	Chr4:137391549-137457172 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028986	protein coding gene	Chr4:140320897-140392591 (+)
A/J	MGP_AJ_G0028945	protein coding gene	Chr4:134350099-134414636 (+)
AKR/J	MGP_AKRJ_G0028897	protein coding gene	Chr4:138204069-138270366 (+)
BALB/cJ	MGP_BALBcJ_G0028969	protein coding gene	Chr4:135031351-135103502 (+)
C3H/HeJ	MGP_C3HHeJ_G0028683	protein coding gene	Chr4:138548750-138614745 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029410	protein coding gene	Chr4:145322186-145390897 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026681	protein coding gene	Chr4:127354686-127418929 (+)
CAST/EiJ	MGP_CASTEiJ_G0028115	protein coding gene	Chr4:136683137-136756594 (+)
CBA/J	MGP_CBAJ_G0028648	protein coding gene	Chr4:149435608-149517512 (+)
DBA/2J	MGP_DBA2J_G0028797	protein coding gene	Chr4:134744718-134810104 (+)
FVB/NJ	MGP_FVBNJ_G0028764	protein coding gene	Chr4:133741116-133809212 (+)
LP/J	MGP_LPJ_G0028896	protein coding gene	Chr4:140408408-140482085 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028790	protein coding gene	Chr4:153446085-153517384 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029448	protein coding gene	Chr4:138679383-138748999 (+)
PWK/PhJ	MGP_PWKPhJ_G0027835	protein coding gene	Chr4:131569659-131638124 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027661	protein coding gene	Chr4:134464045-134531119 (+)
WSB/EiJ	MGP_WSBEiJ_G0028193	protein coding gene	Chr4:138897712-138971921 (+)

Human Ortholog

RAP1GAP, RAP1 GTPase activating protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAP1GAP, RAP1 GTPase activating protein
Synonyms

RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP
Links

HGNC:9858

NCBI Gene ID: 5909

UniProt: P47736
Chr Location

1p36.12; chr1:21596221-21669357 (-) GRCh38

MGI Vertebrate Homology

Rap1gap stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RAP1GAP
Gene Tree

Rap1gap

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

5
Targeted

3
Genomic Mutations

3 involving Rap1gap
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

44
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

897
Tissues

29
cDNA Data

81
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

111
RefSeq

51
UniProt

5
CCDS

CCDS38925.1, CCDS57306.1, CCDS84809.1

Ensembl

ENSMUSG00000041351 (Evidence)
NCBI Gene

110351

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041351	Ensembl Gene Model \| MGI Sequence Detail	65136	C57BL/6J	± kb
transcript	ENSMUST00000105835	Ensembl \| MGI Sequence Detail	4140	Not Applicable
polypeptide	ENSMUSP00000101461	Ensembl \| MGI Sequence Detail	729	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013721 Rap1 GTPase-activating protein 1

(term hierarchy)
InterPro Domains

IPR003109 GoLoco motif

IPR050989 Rap1/Ran GTPase-activating

IPR000331 Rap/Ran-GAP domain

IPR035974 Rap/Ran-GAP superfamily

IPR011990 Tetratricopeptide-like helical domain superfamily
GlyGen

A2ALS5 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 84

cDNA 81

Primer pair 1

Other 2

Microarray probesets 3

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MGD-MRK-38383, MGI:1923530, MGI:1926025, MGI:2140268

Summaries

All 59

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 12
Earliest

J:37223 Gould KA, et al., Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics. 1996 Dec;144(4):1777-85
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rap1gap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39770	Chr4:137392018-137392098 (+)	21 bp
Tssr39771	Chr4:137408900-137408929 (+)	16,878 bp
Tssr39772	Chr4:137408974-137409030 (+)	16,965 bp
Tssr1349	Chr4:137409035-137409046 (+)	17,004 bp
Tssr39773	Chr4:137414701-137414739 (+)	22,683 bp
Tssr39774	Chr4:137434769-137434838 (+)	42,767 bp
Tssr39775	Chr4:137439334-137439352 (+)	47,306 bp
Tssr39776	Chr4:137444641-137444666 (+)	52,617 bp
Tssr39777	Chr4:137444675-137444692 (+)	52,647 bp
Tssr39778	Chr4:137446525-137446534 (+)	54,493 bp
Tssr39779	Chr4:137446555-137446564 (+)	54,523 bp
Tssr39780	Chr4:137446831-137446834 (+)	54,796 bp
Tssr39781	Chr4:137446996-137447036 (+)	54,979 bp
Tssr39782	Chr4:137451757-137451786 (+)	59,735 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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