Rap1gap MGI Mouse Gene Detail - MGI:109338 - Rap1 GTPase-activating protein

Symbol

Rap1gap
Name

Rap1 GTPase-activating protein
Synonyms

1300019I11Rik, 2310004O14Rik, Gap, Rap1ga1

Feature Type

protein coding gene
IDs

MGI:109338
NCBI Gene: 110351
Gene Overview

MyGene.info: RAP1GAP
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:137664726-137729861 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 70.02 cM, cytoband D3
Mapping Data

4 experiments

SNPs within 2kb

798 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109338	protein coding gene	Chr4:137664710-137729861 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028986	protein coding gene	Chr4:140320897-140392591 (+)
A/J	MGP_AJ_G0028945	protein coding gene	Chr4:134350099-134414636 (+)
AKR/J	MGP_AKRJ_G0028897	protein coding gene	Chr4:138204069-138270366 (+)
BALB/cJ	MGP_BALBcJ_G0028969	protein coding gene	Chr4:135031351-135103502 (+)
C3H/HeJ	MGP_C3HHeJ_G0028683	protein coding gene	Chr4:138548750-138614745 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029410	protein coding gene	Chr4:145322186-145390897 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026681	protein coding gene	Chr4:127354686-127418929 (+)
CAST/EiJ	MGP_CASTEiJ_G0028115	protein coding gene	Chr4:136683137-136756594 (+)
CBA/J	MGP_CBAJ_G0028648	protein coding gene	Chr4:149435608-149517512 (+)
DBA/2J	MGP_DBA2J_G0028797	protein coding gene	Chr4:134744718-134810104 (+)
FVB/NJ	MGP_FVBNJ_G0028764	protein coding gene	Chr4:133741116-133809212 (+)
LP/J	MGP_LPJ_G0028896	protein coding gene	Chr4:140408408-140482085 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028790	protein coding gene	Chr4:153446085-153517384 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029448	protein coding gene	Chr4:138679383-138748999 (+)
PWK/PhJ	MGP_PWKPhJ_G0027835	protein coding gene	Chr4:131569659-131638124 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027661	protein coding gene	Chr4:134464045-134531119 (+)
WSB/EiJ	MGP_WSBEiJ_G0028193	protein coding gene	Chr4:138897712-138971921 (+)

Human Ortholog

RAP1GAP, RAP1 GTPase activating protein

Vertebrate Orthologs

8

Human Ortholog

RAP1GAP, RAP1 GTPase activating protein
Orthology source: HomoloGene, HGNC
Synonyms

RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP
Links

HGNC:9858

NCBI Gene ID: 5909

neXtProt AC: NX_P47736

UniProt: P47736
Chr Location

1p36.12; chr1:21596215-21669444 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2163
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: RAP1GAP
Protein SuperFamily

Rap1 GTPase-activating protein
Gene Tree

Rap1gap

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

5
Targeted

2
Genomic Mutations

3 involving Rap1gap
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

24
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

189
Tissues

27
cDNA Data

81
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Rap1gap interacts with 133 markers (Mir1a-1, Mir1a-2, Mir10a, ...) View All

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All Sequences

102
RefSeq

42
UniProt

5
CCDS

CCDS38925.1, CCDS57306.1, CCDS84809.1
UniGene

180763

Ensembl

ENSMUSG00000041351 (Evidence)
NCBI Gene

110351

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041351	Ensembl Gene Model \| MGI Sequence Detail	65136	C57BL/6J	± kb
transcript	ENSMUST00000105835	Ensembl \| MGI Sequence Detail	4140	Not Applicable
polypeptide	ENSMUSP00000101461	Ensembl \| MGI Sequence Detail	729	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013721 Rap1 GTPase-activating protein 1

(term hierarchy)
InterPro Domains

IPR003109 GoLoco motif

IPR000331 Rap GTPase activating protein domain

IPR035974 Rap/Ran-GAP superfamily

IPR011990 Tetratricopeptide-like helical domain superfamily

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All nucleic 83

cDNA 81

Other 2

Microarray probesets 3

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MGD-MRK-38383, MGI:1923530, MGI:1926025, MGI:2140268

Summaries

All 53

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 9
Earliest

J:37223 Gould KA, et al., Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics. 1996 Dec;144(4):1777-85
Latest

J:226997 Bebee TW, et al., The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife. 2015;4

TSS for Rap1gap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39770	Chr4:137664707-137664787 (+)	21 bp
Tssr39771	Chr4:137681589-137681618 (+)	16,878 bp
Tssr39772	Chr4:137681663-137681719 (+)	16,965 bp
Tssr1349	Chr4:137681724-137681735 (+)	17,004 bp
Tssr39773	Chr4:137687390-137687428 (+)	22,683 bp
Tssr39774	Chr4:137707458-137707527 (+)	42,767 bp
Tssr39778	Chr4:137719214-137719223 (+)	54,493 bp
Tssr39779	Chr4:137719244-137719253 (+)	54,523 bp
Tssr39782	Chr4:137724446-137724475 (+)	59,735 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14