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Rap1gap Gene Detail
Summary
  • Symbol
    Rap1gap
  • Name
    Rap1 GTPase-activating protein
  • Synonyms
    1300019I11Rik, 2310004O14Rik, Gap, Rap1ga1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109338
    NCBI Gene: 110351
  • Gene Overview
    MyGene.info: RAP1GAP
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:137664726-137729861 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.02 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    798 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109338
 protein coding gene Chr4:137664710-137729861 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028986
 protein coding gene Chr4:140320897-140392591 (+)
A/J MGP_AJ_G0028945
 protein coding gene Chr4:134350099-134414636 (+)
AKR/J MGP_AKRJ_G0028897
 protein coding gene Chr4:138204069-138270366 (+)
BALB/cJ MGP_BALBcJ_G0028969
 protein coding gene Chr4:135031351-135103502 (+)
C3H/HeJ MGP_C3HHeJ_G0028683
 protein coding gene Chr4:138548750-138614745 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029410
 protein coding gene Chr4:145322186-145390897 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026681
 protein coding gene Chr4:127354686-127418929 (+)
CAST/EiJ MGP_CASTEiJ_G0028115
 protein coding gene Chr4:136683137-136756594 (+)
CBA/J MGP_CBAJ_G0028648
 protein coding gene Chr4:149435608-149517512 (+)
DBA/2J MGP_DBA2J_G0028797
 protein coding gene Chr4:134744718-134810104 (+)
FVB/NJ MGP_FVBNJ_G0028764
 protein coding gene Chr4:133741116-133809212 (+)
LP/J MGP_LPJ_G0028896
 protein coding gene Chr4:140408408-140482085 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028790
 protein coding gene Chr4:153446085-153517384 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029448
 protein coding gene Chr4:138679383-138748999 (+)
PWK/PhJ MGP_PWKPhJ_G0027835
 protein coding gene Chr4:131569659-131638124 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027661
 protein coding gene Chr4:134464045-134531119 (+)
WSB/EiJ MGP_WSBEiJ_G0028193
 protein coding gene Chr4:138897712-138971921 (+)



Homology
more
  • Human Ortholog
    RAP1GAP, RAP1 GTPase activating protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RAP1GAP, RAP1 GTPase activating protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP
  • Links
    NCBI Gene ID: 5909
    neXtProt AC: NX_P47736
    UniProt: P47736

  • Chr Location
    1p36.12; chr1:21596215-21669444 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    189
  • Tissues
    27
  • cDNA Data
    81
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041351 Ensembl Gene Model | MGI Sequence Detail 65136 C57BL/6J ±  kb
transcript ENSMUST00000105835 Ensembl | MGI Sequence Detail 4140 Not Applicable  
polypeptide ENSMUSP00000101461 Ensembl | MGI Sequence Detail 729 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR003109 GoLoco motif
    IPR000331 Rap GTPase activating protein domain
    IPR035974 Rap/Ran-GAP superfamily
    IPR011990 Tetratricopeptide-like helical domain superfamily
Molecular
Reagents
less
  • All nucleic 83
    cDNA 81
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38383, MGI:1923530, MGI:1926025, MGI:2140268
References
more
  • Summaries
    All 51
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:37223 Gould KA, et al., Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice. Genetics. 1996 Dec;144(4):1777-85
  • Latest
    J:226997 Bebee TW, et al., The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife. 2015;4
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/06/2018
MGI 6.13 		The Jackson Laboratory