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Spam1
Gene Detail
Symbol

Name
ID
Spam1
sperm adhesion molecule 1
MGI:109335
Synonyms
Ph-20
Feature Type
protein coding gene
Genetic Map
Chromosome 6
11.28 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:24795824-24801048 bp, + strand
From Ensembl annotation of GRCm38

  5225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7547  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: hyaluronidase
Gene Tree: Spam1

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Male homozygotes for a targeted null mutation are normally fertile, but in vitro their sperm are slower at clearing cells from the cumulus mass.
 
Interactions
Spam1 interacts with 90 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process carbohydrate metabolic process, cell adhesion, ...
Component acrosomal vesicle, anchored component of membrane, ...
Function catalytic activity, hyalurononglucosaminidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100486024 ; ZFIN spam1    NEW 
Molecular
reagents
All nucleic(8) Genomic(2) cDNA(4) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000029682 (Evidence)
Entrez Gene 20690 (Evidence)
UniGene 4688
DFCI TC1587465
DoTS DT.60109906
NIA Mouse Gene Index U006600
EC 3.2.1.35
Consensus CDS Project CCDS19947.1
International Mouse Phenotyping Consortium Status Spam1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029682 Ensembl Gene Model | MGI Sequence Detail 5225 C57BL/6J ±  kb
transcript ENSMUST00000031693 Ensembl | MGI Sequence Detail 2013 Not Applicable 
polypeptide ENSMUSP00000031693 Ensembl | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR017853 Glycoside hydrolase, superfamily
InterPro IPR018155 Hyaluronidase
InterPro IPR001439 Hyaluronidase PH20
Protein Ontology PR:000015464 hyaluronidase PH-20
References
(Earliest) J:38913 Deng X, et al., The mouse Spam1 maps to proximal chromosome 6 and is a candidate for the sperm dysfunction in Rb(6.16)24Lub and Rb(6.15)1Ald heterozygotes. Mamm Genome. 1997 Feb;8(2):94-7
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)
Other
accession IDs
MGD-MRK-38380, MGI:2141611

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory