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Bnip2 Gene Detail
Summary
  • Symbol
    Bnip2
  • Name
    BCL2/adenovirus E1B interacting protein 2
  • Synonyms
    5730523P12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:109327
    NCBI Gene: 12175
  • Gene Overview
    MyGene.info: BNIP2
Location & Maps
more
  • Sequence Map
    Chr9:69989466-70008317 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18852 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 39.15 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BNIP2, BCL2 interacting protein 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    BNIP2, BCL2 interacting protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BNIP-2, NIP2
  • Links
    NCBI Gene ID: 663
    neXtProt AC: NX_Q12982

  • Chr Location
    15q22.2; chr15:59659146-59689529 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3194
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: BNIP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    3
  • Genomic Mutations
    1 involving Bnip2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030864 VEGA Gene Model | MGI Sequence Detail 18852 C57BL/6J ±  kb
transcript OTTMUST00000076383 VEGA | MGI Sequence Detail 1465 Not Applicable  
polypeptide OTTMUSP00000040202 VEGA | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    23 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000004780 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
  • InterPro Domains
    IPR022181 Bcl2-/adenovirus E1B 19kDa-interacting protein 2
    IPR001251 CRAL-TRIO lipid binding domain
Molecular
Reagents
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  • All nucleic 114
    cDNA 114

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-38372, MGI:1923989
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:37511 Boyd JM, et al., Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins [see comments] [published erratum appears in Cell 1994 Dec 16;79(6):following 1120]. Cell. 1994 Oct 21;79(2):341-51
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory