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Bnip3 Gene Detail
Summary
  • Symbol
    Bnip3
  • Name
    BCL2/adenovirus E1B interacting protein 3
  • Synonyms
    Nip3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109326
    NCBI Gene: 12176
  • Gene Overview
    MyGene.info: BNIP3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:138890836-138909506 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 82.95 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109326
protein coding gene Chr7:138890836-138909519 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033144
protein coding gene Chr7:143889765-143905886 (-)
A/J MGP_AJ_G0033126
protein coding gene Chr7:139843683-139862613 (-)
AKR/J MGP_AKRJ_G0033058
protein coding gene Chr7:143614127-143632706 (-)
BALB/cJ MGP_BALBcJ_G0033127
protein coding gene Chr7:139589955-139605191 (-)
C3H/HeJ MGP_C3HHeJ_G0032841
protein coding gene Chr7:143427140-143444827 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033638
protein coding gene Chr7:149223800-149244576 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030611
protein coding gene Chr7:140992329-141011280 (-)
CAST/EiJ MGP_CASTEiJ_G0032171
protein coding gene Chr7:135700716-135721347 (-)
CBA/J MGP_CBAJ_G0032814
protein coding gene Chr7:154255181-154272776 (-)
DBA/2J MGP_DBA2J_G0032966
protein coding gene Chr7:137803965-137824647 (-)
FVB/NJ MGP_FVBNJ_G0032919
protein coding gene Chr7:137684553-137699774 (-)
LP/J MGP_LPJ_G0033060
protein coding gene Chr7:145440162-145458845 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032951
protein coding gene Chr7:154977337-154996559 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033658
protein coding gene Chr7:142608909-142628352 (-)
PWK/PhJ MGP_PWKPhJ_G0031877
protein coding gene Chr7:130976519-130995944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031722
protein coding gene Chr7:129432223-129454666 (-)
WSB/EiJ MGP_WSBEiJ_G0032282
protein coding gene Chr7:143510258-143530506 (-)



Homology
more
  • Human Ortholog
    BNIP3, BCL2 interacting protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BNIP3, BCL2 interacting protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NIP3
  • Links
    NCBI Gene ID: 664
    neXtProt AC: NX_Q12983
    UniProt: Q12983

  • Chr Location
    10q26.3; chr10:131967683-131982013 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased post-ischemic ventricular remodeling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12176 NCBI Gene Model | MGI Sequence Detail 18671 C57BL/6J ±  kb
    transcript NM_009760 RefSeq | MGI Sequence Detail 1756 C57BL/6  
    polypeptide O55003 UniProt | EBI | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      cDNA 144
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38371
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 25
      Gene Ontology 17
      Phenotypes 11
    • Earliest
      J:37511 Boyd JM, et al., Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins [see comments] [published erratum appears in Cell 1994 Dec 16;79(6):following 1120]. Cell. 1994 Oct 21;79(2):341-51
    • Latest
      J:262053 Tan Z, et al., Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions. PLoS Genet. 2018 Apr;14(4):e1007346

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory