Kcnk1 MGI Mouse Gene Detail - MGI:109322 - potassium channel, subfamily K, member 1

Kcnk1 Gene Detail

Symbol

Kcnk1
Name

potassium channel, subfamily K, member 1
Synonyms

TWIK-1

Feature Type

protein coding gene
IDs

MGI:109322
NCBI Gene: 16525
Gene Overview

MyGene.info: KCNK1

Sequence Map

Chr8:125995102-126030683 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

35582 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 73.67 cM
Mapping Data

3 experiments

Human Ortholog

KCNK1, potassium two pore domain channel subfamily K member 1

Vertebrate Orthologs

9

Human Ortholog

KCNK1, potassium two pore domain channel subfamily K member 1
Orthology source: HomoloGene, HGNC
Synonyms

DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK1, TWIK-1
Links

HGNC:6272

NCBI Gene ID: 3775

neXtProt AC: NX_O00180
Chr Location

1q42.2; chr1:233614004-233672512 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 1691
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: KCNK1
Protein SuperFamily

potassium channel, subfamily K type
Gene Tree

Kcnk1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF

Mice homozygous for a null mutation reduced urinary flow rates and on a low phosphate diet display an attenuated ability to increase renal phosphate reabsorption.

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All GO Annotations

34
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

320
Tissues

141
cDNA Data

98
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

Xenbase kcnk1

ZFIN kcnk1a

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Kcnk1 interacts with 177 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

16
RefSeq

4
UniProt

1
CCDS

CCDS22783.1
UniGene

10800

Ensembl

ENSMUSG00000033998 (Evidence)
NCBI Gene

16525

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033998	Ensembl Gene Model \| MGI Sequence Detail	35582	C57BL/6J	± kb
transcript	ENSMUST00000046765	Ensembl \| MGI Sequence Detail	2301	Not Applicable
polypeptide	ENSMUSP00000046103	Ensembl \| MGI Sequence Detail	336	Not Applicable

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SNPs within 2kb

299 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000002071 potassium channel subfamily K member 1
InterPro Domains

IPR013099 Potassium channel domain

IPR003280 Two pore domain potassium channel

IPR003092 Two pore domain potassium channel, TASK family

IPR001779 Two pore domain potassium channel, TWIK-1

IPR005408 Two pore domain potassium channel, TWIK family

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All nucleic 105

Genomic 1

cDNA 100

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-38367, MGI:2142615

Summaries

All 45

Developmental Gene Expression 8

Gene Ontology 7

Phenotypes 8
Earliest

J:38116 Lesage F, et al., The structure, function and distribution of the mouse TWIK-1 K+ channel. FEBS Lett. 1997 Jan 27;402(1):28-32
Latest

J:220468 Walentin K, et al., A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development. 2015 Mar 15;142(6):1125-36

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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