Kcnk1 MGI Mouse Gene Detail - MGI:109322 - potassium channel, subfamily K, member 1

Symbol

Kcnk1
Name

potassium channel, subfamily K, member 1
Synonyms

TWIK-1

Feature Type

protein coding gene
IDs

MGI:109322
NCBI Gene: 16525
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr8:126721909-126757424 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 73.67 cM
Mapping Data

3 experiments

SNPs within 2kb

298 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109322	protein coding gene	Chr8:126718692-126757424 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034291	protein coding gene	Chr8:129792620-129831545 (+)
A/J	MGP_AJ_G0034271	protein coding gene	Chr8:124409640-124445117 (+)
AKR/J	MGP_AKRJ_G0034198	protein coding gene	Chr8:127975511-128012714 (+)
BALB/cJ	MGP_BALBcJ_G0034264	protein coding gene	Chr8:124573212-124609114 (+)
C3H/HeJ	MGP_C3HHeJ_G0033975	protein coding gene	Chr8:128631768-128667945 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034784	protein coding gene	Chr8:134103128-134140358 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031725	protein coding gene	Chr8:117140424-117174275 (+)
CAST/EiJ	MGP_CASTEiJ_G0033302	protein coding gene	Chr8:128779780-128814795 (+)
CBA/J	MGP_CBAJ_G0033948	protein coding gene	Chr8:139043176-139078656 (+)
DBA/2J	MGP_DBA2J_G0034104	protein coding gene	Chr8:123550128-123586090 (+)
FVB/NJ	MGP_FVBNJ_G0034048	protein coding gene	Chr8:122748854-122784658 (+)
LP/J	MGP_LPJ_G0034193	protein coding gene	Chr8:129939160-129976107 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034095	protein coding gene	Chr8:141029084-141067711 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034803	protein coding gene	Chr8:128217633-128253019 (+)
PWK/PhJ	MGP_PWKPhJ_G0033004	protein coding gene	Chr8:123314421-123349659 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032843	protein coding gene	Chr8:126838275-126876410 (+)
WSB/EiJ	MGP_WSBEiJ_G0033419	protein coding gene	Chr8:128950281-128988540 (+)

Human Ortholog

KCNK1, potassium two pore domain channel subfamily K member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNK1, potassium two pore domain channel subfamily K member 1
Synonyms

DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK1, TWIK-1
Links

HGNC:6272

NCBI Gene ID: 3775

neXtProt AC: NX_O00180

UniProt: O00180
Chr Location

1q42.2; chr1:233614004-233672512 (+) GRCh38.p7

Alliance of Genome Resources

Kcnk1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCNK1
Protein SuperFamily

K_channel_subfamily_K_type
Gene Tree

Kcnk1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation reduced urinary flow rates and on a low phosphate diet display an attenuated ability to increase renal phosphate reabsorption.

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All GO Annotations

33
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1026
Tissues

141
cDNA Data

99
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnk1

ZFIN kcnk1a

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Kcnk1 interacts with 177 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS22783.1

Ensembl

ENSMUSG00000033998 (Evidence)
NCBI Gene

16525

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033998	Ensembl Gene Model \| MGI Sequence Detail	35516	C57BL/6J	± kb
transcript	ENSMUST00000046765	Ensembl \| MGI Sequence Detail	2235	Not Applicable
polypeptide	ENSMUSP00000046103	Ensembl \| MGI Sequence Detail	336	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000002071 potassium channel subfamily K member 1

(term hierarchy)
InterPro Domains

IPR013099 Potassium channel domain

IPR003280 Two pore domain potassium channel

IPR003092 Two pore domain potassium channel, TASK family

IPR001779 Two pore domain potassium channel, TWIK-1

IPR005408 Two pore domain potassium channel, TWIK family

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All nucleic 106

Genomic 1

cDNA 101

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-38367, MGI:2142615

Summaries

All 51

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 12
Earliest

J:38116 Lesage F, et al., The structure, function and distribution of the mouse TWIK-1 K+ channel. FEBS Lett. 1997 Jan 27;402(1):28-32
Latest

J:295281 Mao Q, et al., DNMT3a-triggered downregulation of K2p 1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain. Int J Cancer. 2019 Oct 15;145(8):2122-2134

TSS for Kcnk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80087	Chr8:126721878-126721924 (+)	-8 bp
Tssr80088	Chr8:126722080-126722085 (+)	174 bp
Tssr80089	Chr8:126722114-126722143 (+)	220 bp
Tssr80090	Chr8:126722146-126722212 (+)	270 bp
Tssr80091	Chr8:126755990-126756002 (+)	34,087 bp
Tssr80092	Chr8:126756010-126756033 (+)	34,113 bp
Tssr2735	Chr8:126756037-126756040 (+)	34,130 bp
Tssr80093	Chr8:126756055-126756081 (+)	34,159 bp
Tssr2736	Chr8:126756100-126756103 (+)	34,193 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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