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Kcnk1 Gene Detail
Summary
  • Symbol
    Kcnk1
  • Name
    potassium channel, subfamily K, member 1
  • Synonyms
    TWIK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109322
    NCBI Gene: 16525
  • Gene Overview
    MyGene.info: KCNK1
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125995170-126030685 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 73.67 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    299 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109322
 protein coding gene Chr8:125993699-126030685 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034291
 protein coding gene Chr8:129792620-129831545 (+)
A/J MGP_AJ_G0034271
 protein coding gene Chr8:124409640-124445117 (+)
AKR/J MGP_AKRJ_G0034198
 protein coding gene Chr8:127975511-128012714 (+)
BALB/cJ MGP_BALBcJ_G0034264
 protein coding gene Chr8:124573212-124609114 (+)
C3H/HeJ MGP_C3HHeJ_G0033975
 protein coding gene Chr8:128631768-128667945 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034784
 protein coding gene Chr8:134103128-134140358 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031725
 protein coding gene Chr8:117140424-117174275 (+)
CAST/EiJ MGP_CASTEiJ_G0033302
 protein coding gene Chr8:128779780-128814795 (+)
CBA/J MGP_CBAJ_G0033948
 protein coding gene Chr8:139043176-139078656 (+)
DBA/2J MGP_DBA2J_G0034104
 protein coding gene Chr8:123550128-123586090 (+)
FVB/NJ MGP_FVBNJ_G0034048
 protein coding gene Chr8:122748854-122784658 (+)
LP/J MGP_LPJ_G0034193
 protein coding gene Chr8:129939160-129976107 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034095
 protein coding gene Chr8:141029084-141067711 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034803
 protein coding gene Chr8:128217633-128253019 (+)
PWK/PhJ MGP_PWKPhJ_G0033004
 protein coding gene Chr8:123314421-123349659 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032843
 protein coding gene Chr8:126838275-126876410 (+)
WSB/EiJ MGP_WSBEiJ_G0033419
 protein coding gene Chr8:128950281-128988540 (+)



Homology
more
  • Human Ortholog
    KCNK1, potassium two pore domain channel subfamily K member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCNK1, potassium two pore domain channel subfamily K member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK1, TWIK-1
  • Links
    NCBI Gene ID: 3775
    neXtProt AC: NX_O00180
    UniProt: O00180

  • Chr Location
    1q42.2; chr1:233614004-233672512 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation reduced urinary flow rates and on a low phosphate diet display an attenuated ability to increase renal phosphate reabsorption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    320
  • Tissues
    141
  • cDNA Data
    99
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033998 Ensembl Gene Model | MGI Sequence Detail 35516 C57BL/6J ±  kb
    transcript ENSMUST00000046765 Ensembl | MGI Sequence Detail 2235 Not Applicable  
    polypeptide ENSMUSP00000046103 Ensembl | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 1
      cDNA 101
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38367, MGI:2142615
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:38116 Lesage F, et al., The structure, function and distribution of the mouse TWIK-1 K+ channel. FEBS Lett. 1997 Jan 27;402(1):28-32
    • Latest
      J:242531 Bedogni F, et al., Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. Cereb Cortex. 2016 Jun;26(6):2517-2529
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/14/2019
    MGI 6.14     		The Jackson Laboratory