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Myl6 Gene Detail
Summary
  • Symbol
    Myl6
  • Name
    myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
  • Synonyms
    MLC3nm, MLC3NM, Myln
  • Feature Type
    protein coding gene
  • IDs
    MGI:109318
    NCBI Gene: 17904
  • Gene Overview
    MyGene.info: MYL6
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128490859-128493886 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.75 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109318
 protein coding gene Chr10:128490859-128494145 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017867
 protein coding gene Chr10:132234700-132239963 (-)
A/J MGP_AJ_G0017842
 protein coding gene Chr10:126919451-126925478 (-)
AKR/J MGP_AKRJ_G0017805
 protein coding gene Chr10:130641234-130644249 (-)
BALB/cJ MGP_BALBcJ_G0017806
 protein coding gene Chr10:127302995-127306010 (-)
C3H/HeJ MGP_C3HHeJ_G0017629
 protein coding gene Chr10:130804616-130807633 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018261
 protein coding gene Chr10:136710441-136715458 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015939
 protein coding gene Chr10:120852319-120855352 (-)
CAST/EiJ MGP_CASTEiJ_G0017190
 protein coding gene Chr10:131520709-131523727 (-)
CBA/J MGP_CBAJ_G0017599
 protein coding gene Chr10:142276545-142283008 (-)
DBA/2J MGP_DBA2J_G0017705
 protein coding gene Chr10:125986465-125989523 (-)
FVB/NJ MGP_FVBNJ_G0017700
 protein coding gene Chr10:124908345-124911362 (-)
LP/J MGP_LPJ_G0017779
 protein coding gene Chr10:132822650-132827329 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017728
 protein coding gene Chr10:144860022-144864410 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018301
 protein coding gene Chr10:130749600-130752617 (-)
PWK/PhJ MGP_PWKPhJ_G0016975
 protein coding gene Chr10:126242259-126245309 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016764
 protein coding gene Chr10:129847767-129851105 (-)
WSB/EiJ MGP_WSBEiJ_G0017249
 protein coding gene Chr10:130962822-130965838 (-)



Homology
more
  • Human Ortholog
    MYL6, myosin light chain 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYL6, myosin light chain 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ESMLC, LC17, LC17A, LC17B, LC17-GI, LC17-NM, MLC1SM, MLC-3, MLC3NM, MLC3SM
  • Links
    NCBI Gene ID: 4637
    neXtProt AC: NX_P60660
    UniProt: P60660

  • Chr Location
    12q13.2; chr12:56158261-56161582 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 69080
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYL6
  • Gene Tree
    Myl6
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    48
  • Tissues
    47
  • cDNA Data
    415
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17904 NCBI Gene Model | MGI Sequence Detail 3028 C57BL/6J ±  kb
transcript NM_001317217 RefSeq | MGI Sequence Detail 735 C57BL/6  
polypeptide Q60605 UniProt | EBI | MGI Sequence Detail 151 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 417
    cDNA 415
    Primer pair 2

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-38363
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:113707 Hailstones DL, et al., Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. Mol Cell Biol. 1990 Mar;10(3):1095-104
  • Latest
    J:217662 Yuan S, et al., Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E430-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/26/2019
MGI 6.14 		The Jackson Laboratory