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Myl6 Gene Detail
Summary
  • Symbol
    Myl6
  • Name
    myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
  • Synonyms
    MLC3nm, MLC3NM, Myln
  • Feature Type
    protein coding gene
  • IDs
    MGI:109318
    NCBI Gene: 17904
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128326728-128329755 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.75 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109318
protein coding gene Chr10:128326728-128330014 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017867
protein coding gene Chr10:132234700-132239963 (-)
A/J MGP_AJ_G0017842
protein coding gene Chr10:126919451-126925478 (-)
AKR/J MGP_AKRJ_G0017805
protein coding gene Chr10:130641234-130644249 (-)
BALB/cJ MGP_BALBcJ_G0017806
protein coding gene Chr10:127302995-127306010 (-)
C3H/HeJ MGP_C3HHeJ_G0017629
protein coding gene Chr10:130804616-130807633 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018261
protein coding gene Chr10:136710441-136715458 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015939
protein coding gene Chr10:120852319-120855352 (-)
CAST/EiJ MGP_CASTEiJ_G0017190
protein coding gene Chr10:131520709-131523727 (-)
CBA/J MGP_CBAJ_G0017599
protein coding gene Chr10:142276545-142283008 (-)
DBA/2J MGP_DBA2J_G0017705
protein coding gene Chr10:125986465-125989523 (-)
FVB/NJ MGP_FVBNJ_G0017700
protein coding gene Chr10:124908345-124911362 (-)
LP/J MGP_LPJ_G0017779
protein coding gene Chr10:132822650-132827329 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017728
protein coding gene Chr10:144860022-144864410 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018301
protein coding gene Chr10:130749600-130752617 (-)
PWK/PhJ MGP_PWKPhJ_G0016975
protein coding gene Chr10:126242259-126245309 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016764
protein coding gene Chr10:129847767-129851105 (-)
WSB/EiJ MGP_WSBEiJ_G0017249
protein coding gene Chr10:130962822-130965838 (-)



Homology
more
  • Human Ortholog
    MYL6, myosin light chain 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYL6, myosin light chain 6
  • Synonyms
    ESMLC, LC17, LC17A, LC17B, LC17-GI, LC17-NM, MLC1SM, MLC-3, MLC3NM, MLC3SM
  • Links
    NCBI Gene ID: 4637
    neXtProt AC: NX_P60660
    UniProt: P60660

  • Chr Location
    12q13.2; chr12:56158346-56163496 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17904 NCBI Gene Model | MGI Sequence Detail 3028 C57BL/6J ±  kb
transcript NM_001317217 RefSeq | MGI Sequence Detail 735 C57BL/6  
polypeptide Q60605 UniProt | EBI | MGI Sequence Detail 151 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 418
    cDNA 415
    Primer pair 3

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-38363
References
more
  • Summaries
    All 36
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:113707 Hailstones DL, et al., Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. Mol Cell Biol. 1990 Mar;10(3):1095-104
  • Latest
    J:308237 Sun J, et al., Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction. Front Physiol. 2020;11:593966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory