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Papola Gene Detail
Summary
  • Symbol
    Papola
  • Name
    poly (A) polymerase alpha
  • Synonyms
    PapIII, Plap
  • Feature Type
    protein coding gene
  • IDs
    MGI:109301
    NCBI Gene: 18789
  • Gene Overview
    MyGene.info: PAPOLA
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:105784694-105838944 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 56.06 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    273 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109301
protein coding gene Chr12:105784674-105838949 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020096
protein coding gene Chr12:107684779-107738931 (+)
A/J MGP_AJ_G0020050
protein coding gene Chr12:103656833-103715616 (+)
AKR/J MGP_AKRJ_G0020026
protein coding gene Chr12:106660818-106714930 (+)
BALB/cJ MGP_BALBcJ_G0020036
protein coding gene Chr12:104069373-104124589 (+)
C3H/HeJ MGP_C3HHeJ_G0019838
protein coding gene Chr12:107097553-107153230 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020481
protein coding gene Chr12:110998538-111054871 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018093
protein coding gene Chr12:100247374-100300840 (+)
CAST/EiJ MGP_CASTEiJ_G0019380
protein coding gene Chr12:101903178-101958165 (+)
CBA/J MGP_CBAJ_G0019805
protein coding gene Chr12:115415072-115471504 (+)
DBA/2J MGP_DBA2J_G0019922
protein coding gene Chr12:103181271-103236290 (+)
FVB/NJ MGP_FVBNJ_G0019907
protein coding gene Chr12:101962665-102017547 (+)
LP/J MGP_LPJ_G0019997
protein coding gene Chr12:107573844-107629808 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019945
protein coding gene Chr12:118799200-118854575 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020510
protein coding gene Chr12:106059629-106115535 (+)
PWK/PhJ MGP_PWKPhJ_G0019139
protein coding gene Chr12:97764970-97820008 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018943
protein coding gene Chr12:100276529-100335114 (+)
WSB/EiJ MGP_WSBEiJ_G0019437
protein coding gene Chr12:107008863-107066248 (+)



Homology
more
  • Human Ortholog
    PAPOLA, poly(A) polymerase alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAPOLA, poly(A) polymerase alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAP, PAP-alpha
  • Links
    NCBI Gene ID: 10914
    neXtProt AC: NX_P51003
    UniProt: P51003

  • Chr Location
    14q32.2; chr14:96502376-96567116 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021111 Ensembl Gene Model | MGI Sequence Detail 54251 C57BL/6J ±  kb
transcript ENSMUST00000109901 Ensembl | MGI Sequence Detail 4380 Not Applicable  
polypeptide ENSMUSP00000105527 Ensembl | MGI Sequence Detail 739 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 1
    cDNA 24
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-38346
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:33284 Zhao W, et al., Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996 May;16(5):2378-86
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory