About   Help   FAQ
Papola
Gene Detail
 Symbol
Name
ID
Papola
poly (A) polymerase alpha
MGI:109301
Synonyms PapIII, Plap
Feature Type protein coding gene
Genetic Map
Chromosome 12
56.06 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:105784694-105838944 bp, + strand
From VEGA annotation of GRCm38

  54251 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23389  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: poly(A) polymerase
Gene Tree: Papola

Human
homologs
Human Homolog PAPOLA, poly(A) polymerase alpha
NCBI Gene ID 10914
neXtProt AC  NX_P51003
Human Synonyms  PAP
Human Chr (Location)  14q32.31; chr14:96502376-96567116 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(213) : Gene trapped(212) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Papola interacts with 482 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process mRNA polyadenylation, mRNA processing, ...
Component cytoplasm, nucleus
Function ATP binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (102)    Tissues (102)    Images (22)
Theiler Stages: 15, 17, 22
Assay TypeResults
RNA in situ 102
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(23) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000035482 (Evidence)
Ensembl Gene ModelENSMUSG00000021111 (Evidence)
Entrez Gene18789 (Evidence)
DFCITC1576615, TC1586405, TC1600413, TC1630086, TC1661423
DoTSDT.101386998, DT.101387002, DT.101710509, DT.87059513, DT.97344010, DT.97370886, DT.99852416
NIA Mouse Gene IndexU043309
EC2.7.7.19
Consensus CDS ProjectCCDS49163.1
International Mouse Knockout Project StatusPapola
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035482 VEGA Gene Model | MGI Sequence Detail 54251 C57BL/6J ±  kb
transcript OTTMUST00000090828 VEGA | MGI Sequence Detail 4380 Not Applicable 
polypeptide OTTMUSP00000049914 VEGA | MGI Sequence Detail 739 Not Applicable 

For the selected sequences
All sequences(133) RefSeq(15) UniProt(13)
Polymorphisms SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011068 Nucleotidyltransferase, class I, C-terminal-like
InterPro IPR002934 Nucleotidyl transferase domain
InterPro IPR014492 Poly(A) polymerase
InterPro IPR007012 Poly(A) polymerase, central domain
InterPro IPR007010 Poly(A) polymerase, RNA-binding domain
Protein Ontology PR:000012267 poly(A) polymerase alpha
References (Earliest) J:33284 Zhao W, et al., Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996 May;16(5):2378-86
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGD-MRK-38346

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory