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Papola Gene Detail
Summary
  • Symbol
    Papola
  • Name
    poly (A) polymerase alpha
  • Synonyms
    PapIII, Plap
  • Feature Type
    protein coding gene
  • IDs
    MGI:109301
    NCBI Gene: 18789
  • Gene Overview
    MyGene.info: PAPOLA
Location & Maps
more
  • Sequence Map
    Chr12:105784694-105838944 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      54251 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 56.06 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PAPOLA, poly(A) polymerase alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAPOLA, poly(A) polymerase alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAP
  • Links
    NCBI Gene ID: 10914
    neXtProt AC: NX_P51003

  • Chr Location
    14q32.31; chr14:96502376-96567116 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    214
  • Chemically induced (other)
    1
  • Gene trapped
    212
  • Targeted
    1
  • Genomic Mutations
    1 involving Papola
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035482 VEGA Gene Model | MGI Sequence Detail 54251 C57BL/6J ±  kb
transcript OTTMUST00000090828 VEGA | MGI Sequence Detail 4380 Not Applicable  
polypeptide OTTMUSP00000049914 VEGA | MGI Sequence Detail 739 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    273 from dbSNP Build 142
Protein
Information
less
  • UniProt
    14 Sequences
  • Protein Ontology
    PR:000012267 poly(A) polymerase alpha
  • EC
  • InterPro Domains
    IPR011068 Nucleotidyltransferase, class I, C-terminal-like
    IPR014492 Poly(A) polymerase
    IPR007012 Poly(A) polymerase, central domain
    IPR007010 Poly(A) polymerase, RNA-binding domain
    IPR002934 Polymerase, nucleotidyl transferase domain
Molecular
Reagents
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  • All nucleic 25
    Genomic 1
    cDNA 23
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-38346
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:33284 Zhao W, et al., Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996 May;16(5):2378-86
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory