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Papola
Gene Detail
Symbol

Name
ID
Papola
poly (A) polymerase alpha
MGI:109301
Synonyms
PapIII, Plap
Feature Type
protein coding gene
Genetic Map
Chromosome 12
56.06 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:105784694-105838944 bp, + strand
From VEGA annotation of GRCm38

  54251 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23389  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PAPOLA
Protein SuperFamily: poly(A) polymerase
Gene Tree: Papola

Human
homologs
PAPOLA, poly(A) polymerase alpha
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10914
neXtProt AC: NX_P51003

Human Synonyms: PAP

Human Chr (Location): 14q32.31; chr14:96502376-96567116 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(213) : Gene trapped(212) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Papola interacts with 481 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process mRNA polyadenylation, mRNA processing, ...
Component cytoplasm, nucleoplasm, ...
Function ATP binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (102)    Tissues (102)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 102
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase papola ; ZFIN papola    NEW 
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(23) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000035482 (Evidence)
Ensembl Gene Model ENSMUSG00000021111 (Evidence)
Entrez Gene 18789 (Evidence)
DFCI TC1576615, TC1586405, TC1600413, TC1661423, TC1630086
DoTS DT.101387002, DT.99852416, DT.101386998, DT.101710509, DT.97370886, DT.97344010, DT.87059513
NIA Mouse Gene Index U043309
EC 2.7.7.19
Consensus CDS Project CCDS49163.1
International Mouse Phenotyping Consortium Status Papola
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035482 VEGA Gene Model | MGI Sequence Detail 54251 C57BL/6J ±  kb
transcript OTTMUST00000090828 VEGA | MGI Sequence Detail 4380 Not Applicable 
polypeptide OTTMUSP00000049914 VEGA | MGI Sequence Detail 739 Not Applicable 

For the selected sequences
All sequences(131) RefSeq(13) UniProt(13)
Polymorphisms
SNPs within 2kb(273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011068 Nucleotidyltransferase, class I, C-terminal-like
InterPro IPR002934 Nucleotidyl transferase domain
InterPro IPR014492 Poly(A) polymerase
InterPro IPR007012 Poly(A) polymerase, central domain
InterPro IPR007010 Poly(A) polymerase, RNA-binding domain
Protein Ontology PR:000012267 poly(A) polymerase alpha
References
(Earliest) J:33284 Zhao W, et al., Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996 May;16(5):2378-86
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)
Other
accession IDs
MGD-MRK-38346

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory