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Mapkapk2
Gene Detail
Symbol

Name
ID
Mapkapk2
MAP kinase-activated protein kinase 2
MGI:109298
Synonyms
MAPKAP kinase 2, MK2, Rps6kc1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
56.89 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:131053700-131097826 bp, - strand
From VEGA annotation of GRCm38

  44127 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: MAP kinase-activated protein kinase 2/3
Gene Tree: Mapkapk2

Human
homologs
Human Homolog MAPKAPK2, mitogen-activated protein kinase-activated protein kinase 2
NCBI Gene ID 9261
neXtProt AC  NX_P49137
Human Synonyms  MAPKAP-K2, MK2, MK-2
Human Chr (Location)  1q32; chr1:206684949-206734285 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this locus affects the inflammatory response. Homozygous null mice show an increased susceptibility to bacterial infection.
 
Interactions
Mapkapk2 interacts with 185 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process 3'-UTR-mediated mRNA stabilization, cellular response to DNA damage stimulus, ...
Component centrosome, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (166)    Tissues (116)    Images (108)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 128
RT-PCR 38
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049116 (Evidence)
Ensembl Gene ModelENSMUSG00000016528 (Evidence)
Entrez Gene17164 (Evidence)
DFCITC1572380
DoTSDT.101383784, DT.110928325, DT.495945
NIA Mouse Gene IndexU021746
EC2.7.11.1
Consensus CDS ProjectCCDS15266.1
International Mouse Knockout Project StatusMapkapk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049116 VEGA Gene Model | MGI Sequence Detail 44127 C57BL/6J ±  kb
transcript OTTMUST00000125394 VEGA | MGI Sequence Detail 2854 Not Applicable 
polypeptide OTTMUSP00000067994 VEGA | MGI Sequence Detail 386 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(251 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027442 MAP kinase activated protein kinase, C-terminal domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010165 MAP kinase-activated protein kinase 2
References
(Earliest) J:20645 Engel K, et al., The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain. FEBS Lett. 1993 Dec 20;336(1):143-7
(Latest) J:205085 Mao X, et al., MAPKAP kinase 2 (MK2)-dependent and -independent models of blister formation in pemphigus vulgaris. J Invest Dermatol. 2014 Jan;134(1):68-76
All references(92)
Other
accession IDs
MGD-MRK-38343, MGI:2138137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory