Mapkapk2
Gene Detail

Symbol Name ID

Mapkapk2 MAP kinase-activated protein kinase 2 MGI:109298

Synonyms

MAPKAP kinase 2, MK2, Rps6kc1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

56.89 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:131053704-131097543 bp, - strand From NCBI annotation of GRCm38   43840 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: MAP kinase-activated protein kinase 2/3
Gene Tree: Mapkapk2

Human homologs

Human Homolog		MAPKAPK2, mitogen-activated protein kinase-activated protein kinase 2
NCBI Gene ID		9261
neXtProt AC		NX_P49137
Human Synonyms		MAPKAP-K2, MK2, MK-2
Human Chr (Location)		1q32; chr1:206858365-206907630 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Inactivation of this locus affects the inflammatory response. Homozygous null mice show an increased susceptibility to bacterial infection.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	3'-UTR-mediated mRNA stabilization, cellular response to vascular endothelial growth factor stimulus, ...
Component	cytoplasm, nucleus
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (166)    Tissues (116)    Images (108)
Theiler Stages: 28

Assay Type	Results
In situ reporter (knock in)	128
RT-PCR	38

cDNA source data(204)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(207) cDNA(205) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000016528 (Evidence)
Entrez Gene	17164 (Evidence)
UniGene	221235
DFCI	TC1572380
DoTS	DT.101383784, DT.110928325, DT.495945
NIA Mouse Gene Index	U021746
EC	2.7.11.1
Consensus CDS Project	CCDS15266.1
International Mouse Knockout Project Status	Mapkapk2

Sequences

Length	Strain/Species
genomic	17164	NCBI Gene Model | MGI Sequence Detail	43840	C57BL/6J
transcript	NM_008551	RefSeq | MGI Sequence Detail	2586	C57BL/6
polypeptide	P49138	UniProt | EBI | MGI Sequence Detail	386	Not Applicable

All sequences(45) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(219 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010165	MAP kinase-activated protein kinase 2

Graphical View of Protein Domain Structure

References

(Earliest) J:20645 Engel K, et al., The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain. FEBS Lett. 1993 Dec 20;336(1):143-7
(Latest) J:194316 Li YY, et al., Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis. Lab Invest. 2013 Mar;93(3):322-33
All references(83)

Other accession IDs

MGD-MRK-38343, MGI:2138137