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Mapkapk2
Gene Detail
Symbol

Name
ID
Mapkapk2
MAP kinase-activated protein kinase 2
MGI:109298
Synonyms
MAPKAP kinase 2, MK2, Rps6kc1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
56.89 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:131053700-131097826 bp, - strand
From VEGA annotation of GRCm38

  44127 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAPKAPK2
Protein SuperFamily: MAP kinase-activated protein kinase 2/3
Gene Tree: Mapkapk2

Human
homologs
MAPKAPK2, mitogen-activated protein kinase-activated protein kinase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9261
neXtProt AC: NX_P49137

Human Synonyms: MAPKAP-K2, MK2, MK-2

Human Chr (Location): 1q32; chr1:206684912-206734285 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this locus affects the inflammatory response. Homozygous null mice show an increased susceptibility to bacterial infection.
 
Interactions
Mapkapk2 interacts with 185 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (166)    Tissues (115)    Images (108)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 128
RT-PCR 38
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mapkapk2 ; ZFIN mapkapk2a    NEW 
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000049116 (Evidence)
Ensembl Gene Model ENSMUSG00000016528 (Evidence)
Entrez Gene 17164 (Evidence)
DFCI TC1572380
DoTS DT.101383784, DT.110928325, DT.495945
NIA Mouse Gene Index U021746
EC 2.7.11.1
Consensus CDS Project CCDS15266.1
International Mouse Phenotyping Consortium Status Mapkapk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049116 VEGA Gene Model | MGI Sequence Detail 44127 C57BL/6J ±  kb
transcript OTTMUST00000125394 VEGA | MGI Sequence Detail 2854 Not Applicable 
polypeptide OTTMUSP00000067994 VEGA | MGI Sequence Detail 386 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(251 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027442 MAP kinase activated protein kinase, C-terminal domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010165 MAP kinase-activated protein kinase 2
References
(Earliest) J:20645 Engel K, et al., The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain. FEBS Lett. 1993 Dec 20;336(1):143-7
(Latest) J:222510 de Boer JF, et al., Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice. PLoS One. 2014;9(9):e106300
All references(100)
Other
accession IDs
MGD-MRK-38343, MGI:2138137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory