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Mapkapk2 Gene Detail
Summary
  • Symbol
    Mapkapk2
  • Name
    MAP kinase-activated protein kinase 2
  • Synonyms
    MAPKAP kinase 2, MK2, Rps6kc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109298
    NCBI Gene: 17164
  • Gene Overview
    MyGene.info: MAPKAPK2
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131053700-131097826 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 56.89 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    249 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109298
protein coding gene Chr1:131053700-131097843 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016448
protein coding gene Chr1:134461461-134511229 (-)
A/J MGP_AJ_G0016431
protein coding gene Chr1:129492795-129537071 (-)
AKR/J MGP_AKRJ_G0016396
protein coding gene Chr1:133308866-133355612 (-)
BALB/cJ MGP_BALBcJ_G0016391
protein coding gene Chr1:129824487-129871332 (-)
C3H/HeJ MGP_C3HHeJ_G0016217
protein coding gene Chr1:133441562-133486577 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016852
protein coding gene Chr1:139465327-139510336 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014566
protein coding gene Chr1:122627918-122674223 (-)
CAST/EiJ MGP_CASTEiJ_G0015797
protein coding gene Chr1:132439122-132490781 (-)
CBA/J MGP_CBAJ_G0016189
protein coding gene Chr1:144267619-144313848 (-)
DBA/2J MGP_DBA2J_G0016296
protein coding gene Chr1:128458990-128508012 (-)
FVB/NJ MGP_FVBNJ_G0016295
protein coding gene Chr1:127090713-127138658 (-)
LP/J MGP_LPJ_G0016367
protein coding gene Chr1:135774943-135823860 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016320
protein coding gene Chr1:150034467-150079275 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016888
protein coding gene Chr1:133068067-133116128 (-)
PWK/PhJ MGP_PWKPhJ_G0015583
protein coding gene Chr1:127420047-127469096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015370
protein coding gene Chr1:132001737-132048717 (-)
WSB/EiJ MGP_WSBEiJ_G0015859
protein coding gene Chr1:133055033-133099465 (-)



Homology
more
  • Human Ortholog
    MAPKAPK2, mitogen-activated protein kinase-activated protein kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPKAPK2, mitogen-activated protein kinase-activated protein kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAPKAP-K2, MK2, MK-2
  • Links
    NCBI Gene ID: 9261
    neXtProt AC: NX_P49137
    UniProt: P49137

  • Chr Location
    1q32.1; chr1:206684912-206734285 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 6 genetic backgrounds
    13 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Inactivation of this locus affects the inflammatory response. Homozygous null mice show an increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016528 Ensembl Gene Model | MGI Sequence Detail 44127 C57BL/6J ±  kb
    transcript ENSMUST00000016672 Ensembl | MGI Sequence Detail 2854 Not Applicable  
    polypeptide ENSMUSP00000016672 Ensembl | MGI Sequence Detail 386 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38343, MGI:2138137
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 4
      Gene Ontology 15
      Phenotypes 67
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:264576 Wu Y, et al., MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA. Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L371-L381

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory