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Mapkapk2
Gene Detail
 Symbol
Name
ID
Mapkapk2
MAP kinase-activated protein kinase 2
MGI:109298
Synonyms MAPKAP kinase 2, MK2, Rps6kc1
Feature Type protein coding gene
Genetic Map
Chromosome 1
56.89 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:131053704-131097543 bp, - strand
From NCBI annotation of GRCm38

  43840 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56412  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: MAP kinase-activated protein kinase 2/3
Gene Tree: Mapkapk2

Human
homologs
Human Homolog MAPKAPK2, mitogen-activated protein kinase-activated protein kinase 2
NCBI Gene ID 9261
neXtProt AC  NX_P49137
Human Synonyms  MAPKAP-K2, MK2, MK-2
Human Chr (Location)  1q32; chr1:206684949-206734285 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Targeted(7) Gene trapped(1)
 
Inactivation of this locus affects the inflammatory response. Homozygous null mice show an increased susceptibility to bacterial infection.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process 3'-UTR-mediated mRNA stabilization, cellular response to DNA damage stimulus, ...
Component centrosome, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (166)    Tissues (116)    Images (108)
Theiler Stages: 28
Assay TypeResults
In situ reporter (knock in) 128
RT-PCR 38
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000016528 (Evidence)
Entrez Gene17164 (Evidence)
DFCITC1572380
DoTSDT.101383784, DT.110928325, DT.495945
NIA Mouse Gene IndexU021746
EC2.7.11.1
Consensus CDS ProjectCCDS15266.1
International Mouse Knockout Project StatusMapkapk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17164 NCBI Gene Model | MGI Sequence Detail 43840 C57BL/6J ±  kb
transcript NM_008551 RefSeq | MGI Sequence Detail 2586 C57BL/6 
polypeptide P49138 UniProt | EBI | MGI Sequence Detail 386 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(246 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027442 MAP kinase activated protein kinase, C-terminal domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010165 MAP kinase-activated protein kinase 2
Graphical View of Protein Domain Structure
References (Earliest) J:20645 Engel K, et al., The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain. FEBS Lett. 1993 Dec 20;336(1):143-7
(Latest) J:205085 Mao X, et al., MAPKAP kinase 2 (MK2)-dependent and -independent models of blister formation in pemphigus vulgaris. J Invest Dermatol. 2014 Jan;134(1):68-76
All references(90)
Other
accession IDs
MGD-MRK-38343, MGI:2138137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory