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Sqle Gene Detail
Summary
  • Symbol
    Sqle
  • Name
    squalene epoxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:109296
    NCBI Gene: 20775
  • Gene Overview
    MyGene.info: SQLE
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:59315092-59331193 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 25.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109296
protein coding gene Chr15:59315077-59331193 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021882
protein coding gene Chr15:58532341-58548435 (+)
A/J MGP_AJ_G0021842
protein coding gene Chr15:56257983-56274523 (+)
AKR/J MGP_AKRJ_G0021823
protein coding gene Chr15:57804744-57824889 (+)
BALB/cJ MGP_BALBcJ_G0021849
protein coding gene Chr15:56471030-56487143 (+)
C3H/HeJ MGP_C3HHeJ_G0021623
protein coding gene Chr15:57939105-57955263 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022288
protein coding gene Chr15:60790542-60809424 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019825
protein coding gene Chr15:53330209-53346118 (+)
CAST/EiJ MGP_CASTEiJ_G0021140
protein coding gene Chr15:58619337-58637531 (+)
CBA/J MGP_CBAJ_G0021592
protein coding gene Chr15:62920843-62939517 (+)
DBA/2J MGP_DBA2J_G0021716
protein coding gene Chr15:56163466-56179756 (+)
FVB/NJ MGP_FVBNJ_G0021694
protein coding gene Chr15:55211821-55229046 (+)
LP/J MGP_LPJ_G0021786
protein coding gene Chr15:58402056-58418501 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021718
protein coding gene Chr15:67950657-67968960 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022311
protein coding gene Chr15:58211580-58229272 (+)
PWK/PhJ MGP_PWKPhJ_G0020885
protein coding gene Chr15:56179244-56196048 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020722
protein coding gene Chr15:58005849-58022055 (+)
WSB/EiJ MGP_WSBEiJ_G0021195
protein coding gene Chr15:58219600-58238771 (+)



Homology
more
  • Human Ortholog
    SQLE, squalene epoxidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SQLE, squalene epoxidase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 6713
    neXtProt AC: NX_Q14534
    UniProt: Q14534

  • Chr Location
    8q24.13; chr8:124998478-125022283 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2355
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SQLE
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    3
  • Gene trapped
    5
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    5 involving Sqle
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele die before E8.5 with a phenotype consistent with that found in mice with mutations affecting cholesterol synthesis. Mice heterozygous the allele exhibit improved Rett syndrome phenotypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20775 NCBI Gene Model | MGI Sequence Detail 16102 C57BL/6J ±  kb
transcript NM_009270 RefSeq | MGI Sequence Detail 2748 C57BL/6  
polypeptide P52019 UniProt | EBI | MGI Sequence Detail 572 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 168
    cDNA 165
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38341, MGI:2145979
References
more
  • Summaries
    All 68
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 5
    Phenotypes 32
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory