Pdcd6
Gene Detail

Symbol Name ID

Pdcd6 programmed cell death 6 MGI:109283

Synonyms

alg-2, Alg2, MA-3, PS2

Feature Type

protein coding gene

Genetic Map

Chromosome 13

40.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:74303121-74317326 bp, - strand From NCBI annotation of GRCm38   14206 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sorcin-like protein
Gene Tree: Pdcd6

Human homologs

Human Homolog		PDCD6, programmed cell death 6
NCBI Gene ID		10016
neXtProt AC		NX_O75340
Human Synonyms		ALG-2, PEF1B
Human Chr (Location)		5p15.33; chr5:271736-315089 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any developmental defects or immune dysfunction.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	binding, bridging, calcium-dependent protein binding, ...

External Resources: FuncBase

Expression

cDNA source data(117)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(117) cDNA(117)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000021576 (Evidence)
Entrez Gene	18570 (Evidence)
UniGene	24254
DFCI	TC1574126
DoTS	DT.110964807, DT.535646, DT.94275475
NIA Mouse Gene Index	U034968
PDB	1HQV
Consensus CDS Project	CCDS26642.1
International Mouse Knockout Project Status	Pdcd6

Sequences

Length	Strain/Species
genomic	18570	NCBI Gene Model | MGI Sequence Detail	14206	C57BL/6J
transcript	NM_011051	RefSeq | MGI Sequence Detail	1524	C57BL/6
polypeptide	P12815	UniProt | EBI | MGI Sequence Detail	191	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(143 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand-like domain
Protein Ontology	PR:000012457	programmed cell death protein 6

Graphical View of Protein Domain Structure

References

(Earliest) J:37099 Kageyama H, et al., A partial cDNA for a novel protein which has a typical E-F hand structure. Biochim Biophys Acta. 1989 Jul 7;1008(2):255-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)

Other accession IDs

MGD-MRK-38328, MGI:2145399