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Pdcd6
Gene Detail
Symbol

Name
ID
Pdcd6
programmed cell death 6
MGI:109283
Synonyms
alg-2, Alg2, MA-3, PS2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
40.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:74303121-74317326 bp, - strand
From Ensembl annotation of GRCm38

  14206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDCD6
Protein SuperFamily: sorcin-like protein
Gene Tree: Pdcd6

Human
homologs
PDCD6, programmed cell death 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10016
neXtProt AC: NX_O75340

Human Synonyms: ALG2, ALG-2, PEF1B

Human Chr (Location): 5p15.33; chr5:271621-314974 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any developmental defects or immune dysfunction.
 
Interactions
Pdcd6 interacts with 121 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(116)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pdcd6 ; ZFIN pdcd6    NEW 
Molecular
reagents
All nucleic(116) cDNA(116)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021576 (Evidence)
Entrez Gene 18570 (Evidence)
UniGene 24254
DFCI TC1574126
DoTS DT.110964807, DT.535646, DT.94275475
NIA Mouse Gene Index U034968
PDB 1HQV
Consensus CDS Project CCDS26642.1
International Mouse Phenotyping Consortium Status Pdcd6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021576 Ensembl Gene Model | MGI Sequence Detail 14206 C57BL/6J ±  kb
transcript ENSMUST00000022060 Ensembl | MGI Sequence Detail 1524 Not Applicable 
polypeptide ENSMUSP00000022060 Ensembl | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(124 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand domain pair
Protein Ontology PR:000012457 programmed cell death protein 6
References
(Earliest) J:37099 Kageyama H, et al., A partial cDNA for a novel protein which has a typical E-F hand structure. Biochim Biophys Acta. 1989 Jul 7;1008(2):255-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)
Other
accession IDs
MGD-MRK-38328, MGI:2145399

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory