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Speg Gene Detail
Summary
  • Symbol
    Speg
  • Name
    SPEG complex locus
  • Synonyms
    Apeg1, BPEG, D1Bwg1450e, mKIAA1297, SPEG, SPEGalpha, SPEGbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:109282
    NCBI Gene: 11790
  • Gene Overview
    MyGene.info: SPEG
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75375297-75432320 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    437 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109282
protein coding gene Chr1:75375297-75432320 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016186
protein coding gene Chr1:75943145-76004986 (+)
A/J MGP_AJ_G0016169
protein coding gene Chr1:73297916-73355415 (+)
AKR/J MGP_AKRJ_G0016126
protein coding gene Chr1:75330156-75391271 (+)
BALB/cJ MGP_BALBcJ_G0016124
protein coding gene Chr1:73360543-73418684 (+)
C3H/HeJ MGP_C3HHeJ_G0015955
protein coding gene Chr1:75664169-75721717 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016577
protein coding gene Chr1:78896319-78954320 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014298
protein coding gene Chr1:68857473-68914367 (+)
CAST/EiJ MGP_CASTEiJ_G0015539
protein coding gene Chr1:75009384-75066957 (+)
CBA/J MGP_CBAJ_G0015928
protein coding gene Chr1:81463528-81521745 (+)
DBA/2J MGP_DBA2J_G0016029
protein coding gene Chr1:72615802-72673779 (+)
FVB/NJ MGP_FVBNJ_G0016032
protein coding gene Chr1:71820039-71878624 (+)
LP/J MGP_LPJ_G0016101
protein coding gene Chr1:77069060-77130656 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016052
protein coding gene Chr1:84808474-84867569 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016624
protein coding gene Chr1:75397675-75457762 (+)
PWK/PhJ MGP_PWKPhJ_G0015326
protein coding gene Chr1:72092174-72151199 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015104
protein coding gene Chr1:74764720-74816546 (+)
WSB/EiJ MGP_WSBEiJ_G0015601
protein coding gene Chr1:75212116-75269034 (+)



Homology
more
  • Human Ortholog
    SPEG, striated muscle enriched protein kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPEG, striated muscle enriched protein kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APEG1, APEG-1, BPEG, CNM5, MYLK6, SPEGalpha, SPEGbeta
  • Links
    NCBI Gene ID: 10290
    neXtProt AC: NX_Q15772
    UniProt: Q15772

  • Chr Location
    2q35; chr2:219434215-219493632 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55619
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SPEG
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human SPEG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die during the early postnatal period with enlarged, dilated hearts, and decreased cardiac function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11790 NCBI Gene Model | MGI Sequence Detail 57024 C57BL/6J ±  kb
    transcript NM_007463 RefSeq | MGI Sequence Detail 10795 Not Specified  
    polypeptide Q62407 UniProt | EBI | MGI Sequence Detail 3262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-34269, MGD-MRK-38327, MGI:106575, MGI:2138568
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:240652 Quick AP, et al., SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circ Res. 2017 Jan 06;120(1):110-119

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory