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Speg
Gene Detail
 Symbol
Name
ID
Speg
SPEG complex locus
MGI:109282
Synonyms Apeg1, BPEG, D1Bwg1450e, mKIAA1297, SPEG, SPEGalpha, SPEGbeta
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:75375297-75432320 bp, + strand
From VEGA annotation of GRCm38

  57024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55619  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Speg

Human
homologs
Human Homolog SPEG, SPEG complex locus
NCBI Gene ID 10290
neXtProt AC  NX_Q15772
Human Synonyms  APEG1, APEG-1, BPEG, SPEGalpha, SPEGbeta
Human Chr (Location)  2q35; chr2:219434877-219493632 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Spontaneous(1) Targeted(3)
Genomic Mutations involving Speg (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die during the early postnatal period with enlarged, dilated hearts, and decreased cardiac function.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Speg interacts with 216 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cardiac muscle cell development, cardiovascular system development, ...
Component nucleus
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(31) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000019414 (Evidence)
Ensembl Gene ModelENSMUSG00000026207 (Evidence)
Entrez Gene11790 (Evidence)
UniGene275397
DFCITC1581001, TC1584153, TC1690103
DoTSDT.101364208, DT.101367378, DT.40176464, DT.521933
NIA Mouse Gene IndexU000472
EC2.7.11.1
Consensus CDS ProjectCCDS35626.1, CCDS48292.1, CCDS48293.1
International Mouse Knockout Project StatusSpeg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019414 VEGA Gene Model | MGI Sequence Detail 57024 C57BL/6J ±  kb
transcript OTTMUST00000046334 VEGA | MGI Sequence Detail 10801 Not Applicable 
polypeptide OTTMUSP00000020922 VEGA | MGI Sequence Detail 3262 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(18) UniProt(5)
Polymorphisms SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000029141 striated muscle preferentially expressed protein kinase
References (Earliest) J:34158 Hsieh CM, et al., APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. J Biol Chem. 1996 Jul 19;271(29):17354-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGD-MRK-34269, MGD-MRK-38327, MGI:106575, MGI:2138568

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory