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Speg
Gene Detail
Symbol

Name
ID
Speg
SPEG complex locus
MGI:109282
Synonyms
Apeg1, BPEG, D1Bwg1450e, mKIAA1297, SPEG, SPEGalpha, SPEGbeta
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:75375297-75432320 bp, + strand
From VEGA annotation of GRCm38

  57024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55619  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SPEG
Gene Tree: Speg

Human
homologs
SPEG, SPEG complex locus
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10290
neXtProt AC: NX_Q15772

Human Synonyms: APEG1, APEG-1, BPEG, CNM5, SPEGalpha, SPEGbeta

Human Chr (Location): 2q35; chr2:219434192-219493632 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SPEG

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Radiation induced(1) Spontaneous(1) Targeted(4)
Genomic Mutations involving Speg (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele die during the early postnatal period with enlarged, dilated hearts, and decreased cardiac function.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Speg interacts with 215 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cardiac muscle cell development, cardiovascular system development, ...
Component nucleus
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase speg ; ZFIN speg    NEW 
Molecular
reagents
All nucleic(32) cDNA(31) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000019414 (Evidence)
Ensembl Gene Model ENSMUSG00000026207 (Evidence)
Entrez Gene 11790 (Evidence)
UniGene 275397
DFCI TC1690103, TC1584153, TC1581001
DoTS DT.101364208, DT.521933, DT.40176464, DT.101367378
NIA Mouse Gene Index U000472
EC 2.7.11.1
Consensus CDS Project CCDS35626.1, CCDS48292.1, CCDS48293.1
International Mouse Phenotyping Consortium Status Speg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019414 VEGA Gene Model | MGI Sequence Detail 57024 C57BL/6J ±  kb
transcript OTTMUST00000046334 VEGA | MGI Sequence Detail 10801 Not Applicable 
polypeptide OTTMUSP00000020922 VEGA | MGI Sequence Detail 3262 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(36) UniProt(6)
Polymorphisms
SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000029141 striated muscle preferentially expressed protein kinase
References
(Earliest) J:34158 Hsieh CM, et al., APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. J Biol Chem. 1996 Jul 19;271(29):17354-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)
Other
accession IDs
MGD-MRK-34269, MGD-MRK-38327, MGI:106575, MGI:2138568

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory