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Pkp4
Gene Detail
Symbol

Name
ID
Pkp4
plakophilin 4
MGI:109281
Synonyms
5031422I09Rik, 9430019K17Rik, Armrp, p0071
Feature Type
protein coding gene
Genetic Map
Chromosome 2
33.52 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:59160850-59355208 bp, + strand
From VEGA annotation of GRCm38

  194359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pkp4

Human
homologs
Human Homolog PKP4, plakophilin 4
NCBI Gene ID 8502
neXtProt AC  NX_Q99569
Human Synonyms  p0071
Human Chr (Location)  2q24.1; chr2:158456964-158681429 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(128) : Gene trapped(126) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.
 
Interactions
Pkp4 interacts with 191 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell adhesion, cell-cell junction assembly, ...
Component cell-cell contact zone, cell-cell junction, ...
External Resources: FuncBase
Expression
cDNA source data(194)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(196) cDNA(196)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000012706 (Evidence)
Ensembl Gene ModelENSMUSG00000026991 (Evidence)
Entrez Gene227937 (Evidence)
UniGene260938
DFCITC1585379, TC1655007, TC1574778, TC1594446, TC1623584, TC1607888, TC1602856
DoTSDT.101738744, DT.101738742, DT.97379355, DT.101738745, DT.94313207, DT.94304091, DT.494288
NIA Mouse Gene IndexU001796, U202093
Consensus CDS ProjectCCDS16052.1, CCDS50588.1
International Mouse Knockout Project StatusPkp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012706 VEGA Gene Model | MGI Sequence Detail 194359 C57BL/6J ±  kb
transcript OTTMUST00000030307 VEGA | MGI Sequence Detail 4614 Not Applicable 
polypeptide OTTMUSP00000013629 VEGA | MGI Sequence Detail 1190 Not Applicable 

For the selected sequences
All sequences(127) RefSeq(24) UniProt(15)
Polymorphisms
SNPs within 2kb(1560 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
Protein Ontology PR:000012793 plakophilin-4
References
(Earliest) J:36767 Hatzfeld M, et al., Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. J Cell Sci. 1996 Nov;109(Pt 11):2767-78
(Latest) J:196228 Nahorski MS, et al., Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis. Hum Mol Genet. 2012 Dec 15;21(24):5268-79
All references(49)
Other
accession IDs
MGD-MRK-38326, MGI:1915006, MGI:2442314

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory