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Pkp4
Gene Detail
Symbol

Name
ID
Pkp4
plakophilin 4
MGI:109281
Synonyms
5031422I09Rik, 9430019K17Rik, Armrp, p0071
Feature Type
protein coding gene
Genetic Map
Chromosome 2
33.52 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:59160850-59355208 bp, + strand
From VEGA annotation of GRCm38

  194359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PKP4
Gene Tree: Pkp4

Human
homologs
PKP4, plakophilin 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8502
neXtProt AC: NX_Q99569

Human Synonyms: p0071

Human Chr (Location): 2q24.1; chr2:158456880-158681429 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(128) : Gene trapped(126) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.
 
Interactions
Pkp4 interacts with 191 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell adhesion, cell-cell junction assembly, ...
Component cell-cell contact zone, cell-cell junction, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(194)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pkp4    NEW 
Molecular
reagents
All nucleic(196) cDNA(196)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000012706 (Evidence)
Ensembl Gene Model ENSMUSG00000026991 (Evidence)
Entrez Gene 227937 (Evidence)
UniGene 260938
DFCI TC1574778, TC1585379, TC1594446, TC1602856, TC1607888, TC1623584, TC1655007
DoTS DT.101738742, DT.101738744, DT.101738745, DT.494288, DT.94304091, DT.94313207, DT.97379355
NIA Mouse Gene Index U001796, U202093
Consensus CDS Project CCDS16052.1, CCDS50588.1
International Mouse Phenotyping Consortium Status Pkp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012706 VEGA Gene Model | MGI Sequence Detail 194359 C57BL/6J ±  kb
transcript OTTMUST00000030307 VEGA | MGI Sequence Detail 4614 Not Applicable 
polypeptide OTTMUSP00000013629 VEGA | MGI Sequence Detail 1190 Not Applicable 

For the selected sequences
All sequences(122) RefSeq(26) UniProt(8)
Polymorphisms
SNPs within 2kb(1560 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR028443 Plakophilin-4
InterPro IPR028435 Plakophilin/Delta catenin
Protein Ontology PR:000012793 plakophilin-4
References
(Earliest) J:36767 Hatzfeld M, et al., Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. J Cell Sci. 1996 Nov;109(Pt 11):2767-78
(Latest) J:219824 Hendley AM, et al., p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015 Mar 1;399(1):41-53
All references(49)
Other
accession IDs
MGD-MRK-38326, MGI:1915006, MGI:2442314

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory