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Ogn Gene Detail
Summary
  • Symbol
    Ogn
  • Name
    osteoglycin
  • Synonyms
    3110079A16Rik, mimecan, mimican, OG, SLRR3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:109278
    NCBI Gene: 18295
  • Gene Overview
    MyGene.info: OGN
Location & Maps
more
  • Sequence Map
    Chr13:49608071-49624500 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16430 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 25.34 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    OGN, osteoglycin
  • Vertebrate Orthologs
    12
  • Human Ortholog
    OGN, osteoglycin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OG, OIF, SLRR3A
  • Links
    NCBI Gene ID: 4969
    neXtProt AC: NX_P20774

  • Chr Location
    9q22.31; chr9:92383967-92404655 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Ogn
  • Incidental Mutations
Mice homozygous for a disruption in this gene display reduced collagen fiber density and organization, as well as more variability in fibrilar diameter in both the skin and the cornea. Corneal clarity was unaffected whereas skin tensile strength was reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18295 NCBI Gene Model | MGI Sequence Detail 16430 C57BL/6J ±  kb
transcript NM_008760 RefSeq | MGI Sequence Detail 2540 C57BL/6  
polypeptide Q62000 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    43 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 1
    cDNA 16

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38323, MGI:1920487
References
more
  • Summaries
    All 46
    Developmental Gene Expression 13
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:36030 Ujita M, et al., Molecular cloning of the mouse osteoglycin-encoding gene. Gene. 1995 Jun 9;158(2):237-40
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory