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Ogn
Gene Detail
Symbol

Name
ID
Ogn
osteoglycin
MGI:109278
Synonyms
3110079A16Rik, mimecan, mimican, OG, SLRR3A
Feature Type
protein coding gene
Genetic Map
Chromosome 13
25.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:49608071-49624500 bp, + strand
From NCBI annotation of GRCm38

  16430 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8542  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: OGN
Protein SuperFamily: osteoinductive factor precursor
Gene Tree: Ogn

Human
homologs
OGN, osteoglycin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4969
neXtProt AC: NX_P20774

Human Synonyms: OG, OIF, SLRR3A

Human Chr (Location): 9q22; chr9:92383967-92404655 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene display reduced collagen fiber density and organization, as well as more variability in fibrilar diameter in both the skin and the cornea. Corneal clarity was unaffected whereas skin tensile strength was reduced.
 
Interactions
Ogn interacts with 239 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component extracellular exosome, extracellular matrix, ...
Function growth factor activity
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (365)    Tissues (33)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 362
Northern blot 3
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ogn ; ZFIN ogn    NEW 
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(16)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000021390 (Evidence)
Entrez Gene 18295 (Evidence)
DFCI TC1579122
DoTS DT.527975, DT.102555791, DT.528106
NIA Mouse Gene Index U014830
Consensus CDS Project CCDS26505.1
International Mouse Phenotyping Consortium Status Ogn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18295 NCBI Gene Model | MGI Sequence Detail 16430 C57BL/6J ±  kb
transcript NM_008760 RefSeq | MGI Sequence Detail 2540 C57BL/6 
polypeptide Q62000 UniProt | EBI | MGI Sequence Detail 298 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR027211 Mimecan
Protein Ontology PR:000011617 mimecan
Graphical View of Protein Domain Structure
References
(Earliest) J:36030 Ujita M, et al., Molecular cloning of the mouse osteoglycin-encoding gene. Gene. 1995 Jun 9;158(2):237-40
(Latest) J:217339 Beiser KU, et al., Identification of novel SHOX target genes in the developing limb using a transgenic mouse model. PLoS One. 2014;9(6):e98543
All references(46)
Other
accession IDs
MGD-MRK-38323, MGI:1920487

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory