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Ogn Gene Detail
Summary
  • Symbol
    Ogn
  • Name
    osteoglycin
  • Synonyms
    3110079A16Rik, mimecan, mimican, OG, SLRR3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:109278
    NCBI Gene: 18295
  • Gene Overview
    MyGene.info: OGN
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:49608071-49624500 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16430 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 25.34 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    OGN, osteoglycin
  • Vertebrate Orthologs
    12
  • Human Ortholog
    OGN, osteoglycin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OG, OIF, SLRR3A
  • Links
    NCBI Gene ID: 4969
    neXtProt AC: NX_P20774
    UniProt: P20774

  • Chr Location
    9q22.31; chr9:92383271-92404699 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display reduced collagen fiber density and organization, as well as more variability in fibrilar diameter in both the skin and the cornea. Corneal clarity was unaffected whereas skin tensile strength was reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18295 NCBI Gene Model | MGI Sequence Detail 16430 C57BL/6J ±  kb
    transcript NM_008760 RefSeq | MGI Sequence Detail 2540 C57BL/6  
    polypeptide Q62000 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      43 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 16

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38323, MGI:1920487
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 14
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:259026 Fu B, et al., Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity. 2017 Dec 19;47(6):1100-1113.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory