Trim24
Gene Detail

Symbol Name ID

Trim24 tripartite motif-containing 24 MGI:109275

Synonyms

A130082H20Rik, D430004I05Rik, Tif1a, TIF1alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 6

17.07 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:37870811-37966296 bp, + strand From VEGA annotation of GRCm38   95486 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20830  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Trim24

Human homologs

Human Homolog		TRIM24, tripartite motif containing 24
NCBI Gene ID		8805
neXtProt AC		NX_O15164
Human Synonyms		hTIF1, PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA
Human Chr (Location)		7q32-q34; chr7:138145079-138270333 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TRIM24

Alleles and phenotypes

All alleles(48) : Targeted(4) Gene trapped(44)
 

Mice homozygous for a knock-out allele exhibit increased hepatocyte ploidy and uncontrolled hepatocellular proliferation; most adult mice develop malignant hepatocellular carcinomas.

 

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	calcium ion homeostasis, cellular response to estrogen stimulus, ...
Component	cytoplasm, intracellular, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (196)    Tissues (120)    Images (36)
Theiler Stages: 2, 3, 4, 5, 11, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	133
Northern blot	1
Western blot	7
RT-PCR	51

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(19) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030316 (Evidence)
Ensembl Gene Model	ENSMUSG00000029833 (Evidence)
Entrez Gene	21848 (Evidence)
DFCI	TC1574963, TC1607229, TC1611743, TC1653264, TC1669996
DoTS	DT.101309591, DT.101736780, DT.102545940, DT.91572747, DT.94211347
EC	6.3.2.-
Consensus CDS Project	CCDS20008.1
International Mouse Knockout Project Status	Trim24

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030316	VEGA Gene Model | MGI Sequence Detail	95486	C57BL/6J
transcript	OTTMUST00000075084	VEGA | MGI Sequence Detail	4042	Not Applicable
polypeptide	OTTMUSP00000039294	VEGA | MGI Sequence Detail	1051	Not Applicable

All sequences(60) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(240 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003649	B-box, C-terminal
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR000315	Zinc finger, B-box
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
Protein Ontology	PR:000016649	transcription intermediary factor 1-alpha

References

(Earliest) J:30466 Miki T, et al., Development of a highly efficient expression cDNA cloning system: application to oncogene isolation. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5167-71
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(57)

Other accession IDs

MGD-MRK-38320, MGI:1889824, MGI:2442432, MGI:2445188