Vipr1
Gene Detail

Symbol Name ID

Vipr1 vasoactive intestinal peptide receptor 1 MGI:109272

Synonyms

VIP-R1, VIP receptor subtype 1, VPAC1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

72.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:121642716-121672954 bp, + strand From VEGA annotation of GRCm38   30239 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3399  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Vipr1

Human homologs

Human Homolog		VIPR1, vasoactive intestinal peptide receptor 1
NCBI Gene ID		7433
neXtProt AC		NX_P32241
Human Synonyms		HVR1, II, PACAP-R2, PACAP-R-2, RDC1, V1RG, VAPC1, VIPR, VIP-R-1, VIRG, VPAC1, VPAC1R, VPCAP1R
Human Chr (Location)		3p22; chr3:42530791-42579065 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit prenatal lethality associated with severe neonatal growth failure, enlarged cecum, intestinal hemorrhage, and enterocyte hyperproliferation in addition to disorganized islets and impaired glucose homeostasis in surviving mice.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	cytoplasm, integral to membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 21

Assay Type	Results
RT-PCR	1

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(1) cDNA(6) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000027442 (Evidence)
Ensembl Gene Model	ENSMUSG00000032528 (Evidence)
Entrez Gene	22354 (Evidence)
DFCI	TC1587764, TC1606394
DoTS	DT.91415158, DT.94243285
NIA Mouse Gene Index	U011165, U150769
Consensus CDS Project	CCDS23633.1
International Mouse Knockout Project Status	Vipr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027442	VEGA Gene Model | MGI Sequence Detail	30239	C57BL/6J
transcript	OTTMUST00000067900	VEGA | MGI Sequence Detail	4902	Not Applicable
polypeptide	OTTMUSP00000034240	VEGA | MGI Sequence Detail	459	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(169 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
InterPro	IPR001571	GPCR, family 2, vasoactive intestinal peptide receptor
InterPro	IPR001771	GPCR, family 2, vasoactive intestinal peptide receptor 1
Protein Ontology	PR:000017300	vasoactive intestinal polypeptide receptor 1

References

(Earliest) J:36171 Delgado M, et al., Differential expression of vasoactive intestinal peptide receptors 1 and 2 (VIP-R1 and VIP-R2) mRNA in murine lymphocytes. J Neuroimmunol. 1996 Aug;68(1-2):27-38
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(38)

Other accession IDs

MGD-MRK-38317, MGI:2143260