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Vipr1
Gene Detail
 Symbol
Name
ID
Vipr1
vasoactive intestinal peptide receptor 1
MGI:109272
Synonyms VIP-R1, VIP receptor subtype 1, VPAC1
Feature Type protein coding gene
Genetic Map
Chromosome 9
72.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:121642716-121672954 bp, + strand
From VEGA annotation of GRCm38

  30239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3399  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Vipr1

Human
homologs
Human Homolog VIPR1, vasoactive intestinal peptide receptor 1
NCBI Gene ID 7433
neXtProt AC  NX_P32241
Human Synonyms  HVR1, II, PACAP-R2, PACAP-R-2, RDC1, V1RG, VAPC1, VIPR, VIP-R-1, VIRG, VPAC1, VPAC1R, VPCAP1R
Human Chr (Location)  3p22; chr3:42489299-42537573 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit prenatal lethality associated with severe neonatal growth failure, enlarged cecum, intestinal hemorrhage, and enterocyte hyperproliferation in addition to disorganized islets and impaired glucose homeostasis in surviving mice.
 
Interactions
Vipr1 interacts with 310 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 21
Assay TypeResults
RT-PCR 1
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(6) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027442 (Evidence)
Ensembl Gene ModelENSMUSG00000032528 (Evidence)
Entrez Gene22354 (Evidence)
DFCITC1587764, TC1606394
DoTSDT.91415158, DT.94243285
NIA Mouse Gene IndexU011165, U150769
Consensus CDS ProjectCCDS23633.1
International Mouse Knockout Project StatusVipr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027442 VEGA Gene Model | MGI Sequence Detail 30239 C57BL/6J ±  kb
transcript OTTMUST00000067900 VEGA | MGI Sequence Detail 4902 Not Applicable 
polypeptide OTTMUSP00000034240 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(243 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR001571 GPCR, family 2, vasoactive intestinal peptide receptor
InterPro IPR001771 GPCR, family 2, vasoactive intestinal peptide receptor 1
Protein Ontology PR:000017300 vasoactive intestinal polypeptide receptor 1
References (Earliest) J:36171 Delgado M, et al., Differential expression of vasoactive intestinal peptide receptors 1 and 2 (VIP-R1 and VIP-R2) mRNA in murine lymphocytes. J Neuroimmunol. 1996 Aug;68(1-2):27-38
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(39)
Other
accession IDs
MGD-MRK-38317, MGI:2143260

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory