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Vasp
Gene Detail
Symbol

Name
ID
Vasp
vasodilator-stimulated phosphoprotein
MGI:109268
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.51 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19256929-19271817 bp, - strand
From VEGA annotation of GRCm38

  14889 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: VASP
Protein SuperFamily: vasodilator-stimulated phosphoprotein
Gene Tree: Vasp

Human
homologs
VASP, vasodilator-stimulated phosphoprotein
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7408
neXtProt AC: NX_P50552

Human Chr (Location): 19q13.32; chr19:45507430-45526989 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(48) Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mutants exhibit hyperplasia of megakaryocytes, and mutant platelets activated by thrombin display two-fold higher surface expression of P-selectin and fibrinogen binding.
 
Interactions
Vasp interacts with 145 markers (Mir10b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin cytoskeleton organization, actin polymerization or depolymerization, ...
Component bicellular tight junction, cell junction, ...
Function actin binding, profilin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (42)    Tissues (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 42
cDNA source data(125)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vasp ; ZFIN vaspb    NEW 
Molecular
reagents
All nucleic(126) Genomic(1) cDNA(125)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024627 (Evidence)
Ensembl Gene Model ENSMUSG00000030403 (Evidence)
Entrez Gene 22323 (Evidence)
UniGene 9684
DFCI TC1758723, TC1573440
DoTS DT.111004974, DT.94358108, DT.99865753
NIA Mouse Gene Index U028218
Consensus CDS Project CCDS52056.1
International Mouse Phenotyping Consortium Status Vasp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024627 VEGA Gene Model | MGI Sequence Detail 14889 C57BL/6J ±  kb
transcript OTTMUST00000060545 VEGA | MGI Sequence Detail 2215 Not Applicable 
polypeptide OTTMUSP00000029531 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(7) UniProt(1)
Polymorphisms
SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000697 EVH1
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017354 Vasodilator-stimulated phosphoprotein
InterPro IPR014885 VASP tetramerisation
Protein Ontology PR:000017263 vasodilator-stimulated phosphoprotein
References
(Earliest) J:35442 Zimmer M, et al., Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization. Genomics. 1996 Sep 1;36(2):227-33
(Latest) J:215575 Cheng AM, et al., Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance. Am J Physiol Endocrinol Metab. 2014 Oct 1;307(7):E571-9
All references(78)
Other
accession IDs
MGD-MRK-38313, MGI:3034831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory