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Vasp
Gene Detail
 Symbol
Name
ID
Vasp
vasodilator-stimulated phosphoprotein
MGI:109268
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.51 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19256929-19271817 bp, - strand
From VEGA annotation of GRCm38

  14889 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle

Protein SuperFamily: vasodilator-stimulated phosphoprotein
Gene Tree: Vasp

Human
homologs
Human Homolog VASP, vasodilator-stimulated phosphoprotein
NCBI Gene ID 7408
neXtProt AC  NX_P50552
Human Chr (Location)  19q13.32; chr19:45507430-45526989 (+)  GRCh38
Alleles
and
phenotypes
All alleles(52) : Gene trapped(48) Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mutants exhibit hyperplasia of megakaryocytes, and mutant platelets activated by thrombin display two-fold higher surface expression of P-selectin and fibrinogen binding.
 
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin cytoskeleton organization, actin polymerization or depolymerization, ...
Component cell junction, cell projection, ...
Function actin binding, profilin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (42)    Tissues (31)   
Theiler Stages: 18, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Western blot 42
cDNA source data(125)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(126) Genomic(1) cDNA(125)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024627 (Evidence)
Ensembl Gene ModelENSMUSG00000030403 (Evidence)
Entrez Gene22323 (Evidence)
UniGene9684
DFCITC1573440, TC1758723
DoTSDT.111004974, DT.94358108, DT.99865753
NIA Mouse Gene IndexU028218
Consensus CDS ProjectCCDS52056.1
International Mouse Knockout Project StatusVasp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024627 VEGA Gene Model | MGI Sequence Detail 14889 C57BL/6J ±  kb
transcript OTTMUST00000060545 VEGA | MGI Sequence Detail 2215 Not Applicable 
polypeptide OTTMUSP00000029531 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(7) UniProt(1)
Polymorphisms SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000697 EVH1
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017354 Vasodilator-stimulated phosphoprotein
InterPro IPR014885 VASP tetramerisation
Protein Ontology PR:000017263 vasodilator-stimulated phosphoprotein
References (Earliest) J:35442 Zimmer M, et al., Cloning of the VASP (vasodilator-stimulated phosphoprotein) genes in human and mouse: structure, sequence, and chromosomal localization. Genomics. 1996 Sep 1;36(2):227-33
(Latest) J:208564 Tateya S, et al., VASP increases hepatic fatty acid oxidation by activating AMPK in mice. Diabetes. 2013 Jun;62(6):1913-22
All references(78)
Other
accession IDs
MGD-MRK-38313, MGI:3034831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory