Gzme
Gene Detail

Symbol Name ID

Gzme granzyme E MGI:109265

Synonyms

CCP3, Ctla6, Ctla-6, MCSP-2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr14:56117619-56120625 bp, - strand From NCBI annotation of GRCm38   3007 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:133275  Vertebrate Homology Class
4 mouse; 1 rat

Protein SuperFamily: trypsin
Gene Tree: Gzme

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	cytolysis, proteolysis
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (4)   
Theiler Stages: 20, 22, 28

Assay Type	Results
RT-PCR	10

cDNA source data(10)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(8) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022156 (Evidence)
Entrez Gene	14942 (Evidence)
UniGene	14424
NIA Mouse Gene Index	U035601
EC	3.4.21.-
Consensus CDS Project	CCDS27143.1
International Mouse Knockout Project Status	Gzme

Sequences

Length	Strain/Species
genomic	14942	NCBI Gene Model | MGI Sequence Detail	3007	C57BL/6J
transcript	NM_010373	RefSeq | MGI Sequence Detail	923	C57BL/6
polypeptide	P08884	UniProt | EBI | MGI Sequence Detail	248	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000003484	granzyme E

Graphical View of Protein Domain Structure

References

(Earliest) J:21438 Jenne D, et al., Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4814-8
(Latest) J:152946 Sferruzzi-Perri AN, et al., Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21
All references(30)

Other accession IDs

MGD-MRK-2226, MGD-MRK-2236, MGD-MRK-38310