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Gzme
Gene Detail
Symbol

Name
ID
Gzme
granzyme E
MGI:109265
Synonyms
CCP3, Ctla6, Ctla-6, MCSP-2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr14:56117619-56120625 bp, - strand
From NCBI annotation of GRCm38

  3007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133275  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee

Protein SuperFamily: trypsin
Gene Tree: Gzme

Human
homologs
Human Homolog GZMH, granzyme H (cathepsin G-like 2, protein h-CCPX)
NCBI Gene ID 2999
neXtProt AC  NX_P20718
Human Synonyms  CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
Human Chr (Location)  14q11.2; chr14:24606480-24609720 (-)  GRCh38
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gzme interacts with 22 markers (Mir129-1, Mir129-2, Mir153, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cytolysis, granzyme-mediated apoptotic signaling pathway, ...
Component membrane, secretory granule
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(10)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(8) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022156 (Evidence)
Entrez Gene14942 (Evidence)
UniGene14424
NIA Mouse Gene IndexU035601
EC3.4.21.-
Consensus CDS ProjectCCDS27143.1
International Mouse Knockout Project StatusGzme
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14942 NCBI Gene Model | MGI Sequence Detail 3007 C57BL/6J ±  kb
transcript NM_010373 RefSeq | MGI Sequence Detail 923 C57BL/6 
polypeptide P08884 UniProt | EBI | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(88 from dbSNP Build 137)    SNPs within 2kb including multiple locations(96)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003484 granzyme E
Graphical View of Protein Domain Structure
References
(Earliest) J:21438 Jenne D, et al., Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4814-8
(Latest) J:152946 Sferruzzi-Perri AN, et al., Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21
All references(32)
Other
accession IDs
MGD-MRK-2226, MGD-MRK-2236, MGD-MRK-38310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory