About   Help   FAQ
Gzme
Gene Detail
Symbol

Name
ID
Gzme
granzyme E
MGI:109265
Synonyms
CCP3, Ctla6, Ctla-6, MCSP-2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr14:56117619-56120625 bp, - strand
From NCBI annotation of GRCm38

  3007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133275  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee

HCOP human homology predictions: GZMB, GZMH
Protein SuperFamily: trypsin
Gene Tree: Gzme

Human
homologs
GZMB, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Orthology source: HGNC

IDs:
NCBI Gene ID: 3002
neXtProt AC: NX_P10144

Human Synonyms: CCPI, CGL1, CGL-1, CSPB, CSP-B, CTLA1, CTSGL1, HLP, SECT

Human Chr (Location): 14q11.2; chr14:24630948-24634226 (-)  GRCh38.p2

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Gzme interacts with 22 markers (Mir129-1, Mir129-2, Mir153, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cytolysis, granzyme-mediated apoptotic signaling pathway, ...
Component cytoplasm, intracellular membrane-bounded organelle, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(10)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(8) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022156 (Evidence)
Entrez Gene 14942 (Evidence)
UniGene 14424
NIA Mouse Gene Index U035601
EC 3.4.21.-
Consensus CDS Project CCDS27143.1
International Mouse Phenotyping Consortium Status Gzme
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14942 NCBI Gene Model | MGI Sequence Detail 3007 C57BL/6J ±  kb
transcript NM_010373 RefSeq | MGI Sequence Detail 923 C57BL/6 
polypeptide P08884 UniProt | EBI | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(88 from dbSNP Build 137)    SNPs within 2kb including multiple locations(96)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003484 granzyme E
Graphical View of Protein Domain Structure
References
(Earliest) J:21438 Jenne D, et al., Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4814-8
(Latest) J:152946 Sferruzzi-Perri AN, et al., Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21
All references(31)
Other
accession IDs
MGD-MRK-2226, MGD-MRK-2236, MGD-MRK-38310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory