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Gzme Gene Detail
Summary
  • Symbol
    Gzme
  • Name
    granzyme E
  • Synonyms
    CCP3, Ctla6, Ctla-6, MCSP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109265
    NCBI Gene: 14942
Location & Maps
more
  • Sequence Map
    Chr14:56117619-56120625 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3007 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    GZMB, granzyme B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GZMB, granzyme B
    Orthology source: HGNC, HGNC
  • Synonyms
    C11, CCPI, CGL1, CGL-1, CSPB, CSP-B, CTLA1, CTSGL1, HLP, SECT
  • Links
    NCBI Gene ID: 3002
    neXtProt AC: NX_P10144

  • Chr Location
    14q11.2; chr14:24630948-24634226 (-)  GRCh38.p2

  • Human Ortholog
    GZMH, granzyme H
    Orthology source: HomoloGene, HGNC, HGNC
  • Synonyms
    CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
  • Links
    NCBI Gene ID: 2999
    neXtProt AC: NX_P20718

  • Chr Location
    14q11.2; chr14:24606480-24609774 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    1
  • Chemically induced (other)
    1
  • Genomic Mutations
    1 involving Gzme
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14942 NCBI Gene Model | MGI Sequence Detail 3007 C57BL/6J ±  kb
transcript NM_010373 RefSeq | MGI Sequence Detail 923 C57BL/6  
polypeptide P08884 UniProt | EBI | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    84 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003484 granzyme E
  • EC
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 20
    Genomic 8
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-2226, MGD-MRK-2236, MGD-MRK-38310
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:21438 Jenne D, et al., Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4814-8
  • Latest
    J:152946 Sferruzzi-Perri AN, et al., Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory