About   Help   FAQ
Gzme Gene Detail
Summary
  • Symbol
    Gzme
  • Name
    granzyme E
  • Synonyms
    CCP3, Ctla6, Ctla-6, MCSP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109265
    NCBI Gene: 14942
  • Gene Overview
    MyGene.info: GZMB
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56117626-56120625 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109265
protein coding gene Chr14:56117619-56120625 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021385
protein coding gene Chr14:50188964-50191970 (-)
A/J MGP_AJ_G0021344
protein coding gene Chr14:49192920-49195894 (-)
AKR/J MGP_AKRJ_G0021320
protein coding gene Chr14:50951428-50954377 (-)
BALB/cJ MGP_BALBcJ_G0021347
protein coding gene Chr14:49162995-49171862 (-)
C3H/HeJ MGP_C3HHeJ_G0021128
protein coding gene Chr14:50635879-50638827 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021787
protein coding gene Chr14:52710208-52713212 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019329
protein coding gene Chr14:47404466-47407511 (-)
CAST/EiJ MGP_CASTEiJ_G0020647
protein coding gene Chr14:46933563-46935787 (-)
CBA/J MGP_CBAJ_G0021095
protein coding gene Chr14:54255373-54258321 (-)
DBA/2J MGP_DBA2J_G0021216
protein coding gene Chr14:48916309-48919248 (-)
FVB/NJ MGP_FVBNJ_G0021198
protein coding gene Chr14:48344818-48347790 (-)
LP/J MGP_LPJ_G0021290
protein coding gene Chr14:51235545-51238551 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021222
protein coding gene Chr14:53620440-53623444 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021813
protein coding gene Chr14:50136107-50141846 (-)
PWK/PhJ MGP_PWKPhJ_G0020392
protein coding gene Chr14:45454802-45457766 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020222
protein coding gene Chr14:46205494-46241301 (-)
WSB/EiJ MGP_WSBEiJ_G0020701
protein coding gene Chr14:50434055-50480726 (-)



Homology
more
  • Human Ortholog
    GZMB, granzyme B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GZMB, granzyme B
    Orthology source: HGNC
  • Synonyms
    C11, CCPI, CGL1, CGL-1, CSPB, CSP-B, CTLA1, CTSGL1, HLP, SECT
  • Links
    NCBI Gene ID: 3002
    neXtProt AC: NX_P10144
    UniProt: P10144

  • Chr Location
    14q12; chr14:24630954-24634226 (-)  GRCh38.p7

  • Human Ortholog
    GZMH, granzyme H
    Orthology source: HomoloGene
  • Synonyms
    CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
  • Links
    NCBI Gene ID: 2999
    neXtProt AC: NX_P20718
    UniProt: P20718

  • Chr Location
    14q12; chr14:24606480-24609763 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022156 Ensembl Gene Model | MGI Sequence Detail 3000 C57BL/6J ±  kb
transcript ENSMUST00000089549 Ensembl | MGI Sequence Detail 916 Not Applicable  
polypeptide ENSMUSP00000086978 Ensembl | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 8
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2226, MGD-MRK-2236, MGD-MRK-38310
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:39247 Masson D, et al., A family of serine esterases in lytic granules of cytolytic T lymphocytes. Cell. 1987 Jun 5;49(5):679-85
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory