About   Help   FAQ
Tsn Gene Detail
Summary
  • Symbol
    Tsn
  • Name
    translin
  • Synonyms
    2610034C24Rik, TB-RBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:109263
    NCBI Gene: 22099
  • Gene Overview
    MyGene.info: TSN
Location & Maps
more
  • Sequence Map
    Chr1:118294778-118311739 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16962 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.14 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TSN, translin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TSN, translin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN
  • Links
    NCBI Gene ID: 7247
    neXtProt AC: NX_Q15631

  • Chr Location
    2q21.1; chr2:121755545-121767853 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3397
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: TSN
  • Gene Tree
    Tsn
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    2
  • Gene trapped
    12
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Tsn
  • Incidental Mutations
Inactivation of this gene results in reduced female fertility, growth defects, and abnormalities related to activity and dexterity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049222 VEGA Gene Model | MGI Sequence Detail 16962 C57BL/6J ±  kb
transcript OTTMUST00000125567 VEGA | MGI Sequence Detail 7063 Not Applicable  
polypeptide OTTMUSP00000068037 VEGA | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    54 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 2
    cDNA 13

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-38308, MGI:1916495, MGI:2138483
References
more
  • Summaries
    All 46
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:38719 Kwon YK, et al., Binding of a phosphoprotein to the 3' untranslated region of the mouse protamine 2 mRNA temporally represses its translation. Mol Cell Biol. 1993 Oct;13(10):6547-57
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory