Gzmc
Gene Detail

Symbol Name ID

Gzmc granzyme C MGI:109256

Synonyms

CCP2, Ctla5, Ctla-5

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr14:56231401-56234656 bp, - strand From NCBI annotation of GRCm38   3256 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:133274  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Gzmc

Human homologs

Human Homolog		GZMH, granzyme H (cathepsin G-like 2, protein h-CCPX)
NCBI Gene ID		2999
neXtProt AC		NX_P20718
Human Synonyms		CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
Human Chr (Location)		14q11.2; chr14:25075686-25078926 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	cytolysis, proteolysis
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (4)   
Theiler Stages: 20, 22, 28

Assay Type	Results
RT-PCR	10

cDNA source data(11)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(8) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000079186 (Evidence)
Entrez Gene	14940 (Evidence)
UniGene	14465
DFCI	TC1586386
DoTS	DT.101363199, DT.488880
EC	3.4.21.-
PDB	3FZZ, 3G01
Consensus CDS Project	CCDS27146.1
International Mouse Knockout Project Status	Gzmc

Sequences

Length	Strain/Species
genomic	14940	NCBI Gene Model | MGI Sequence Detail	3256	C57BL/6J
transcript	NM_010371	RefSeq | MGI Sequence Detail	934	Not Specified
polypeptide	P08882	UniProt | EBI | MGI Sequence Detail	248	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000003487	granzyme C

Graphical View of Protein Domain Structure

References

(Earliest) J:8216 Lobe CG, et al., Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1448-52
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Other accession IDs

MGD-MRK-2235, MGD-MRK-38301, MGI:2145616