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Gzmc
Gene Detail
Symbol

Name
ID
Gzmc
granzyme C
MGI:109256
Synonyms
CCP2, Ctla5, Ctla-5
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:56231401-56234656 bp, - strand
From Ensembl annotation of GRCm38

  3256 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105844  Vertebrate Homology Class
1 mouse; 2 rat

Protein SuperFamily: trypsin
Gene Tree: Gzmc

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gzmc interacts with 26 markers (Mir22, Mir101a, Mir133b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cytolysis, granzyme-mediated apoptotic signaling pathway, ...
Component secretory granule
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(11)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(8) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000079186 (Evidence)
Entrez Gene14940 (Evidence)
UniGene14465
DFCITC1586386
DoTSDT.101363199, DT.488880
EC3.4.21.-
PDB3FZZ, 3G01
Consensus CDS ProjectCCDS27146.1
International Mouse Knockout Project StatusGzmc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079186 Ensembl Gene Model | MGI Sequence Detail 3256 C57BL/6J ±  kb
transcript ENSMUST00000015585 Ensembl | MGI Sequence Detail 934 Not Applicable 
polypeptide ENSMUSP00000015585 Ensembl | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(87 from dbSNP Build 137)    SNPs within 2kb including multiple locations(91)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003487 granzyme C
References
(Earliest) J:8216 Lobe CG, et al., Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1448-52
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGD-MRK-2235, MGD-MRK-38301, MGI:2145616

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory