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Gzmc Gene Detail
Summary
  • Symbol
    Gzmc
  • Name
    granzyme C
  • Synonyms
    CCP2, Ctla-5, Ctla5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109256
    NCBI Gene: 14940
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56468898-56472113 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109256
 protein coding gene Chr14:56468854-56479102 (-)
129S1/SvImJ ENSMUSG00200041315
 protein coding gene Chr14:45053434-45056649 (-)
A/J ENSMUSG00195030024
 protein coding gene Chr14:45268620-45271835 (-)
AKR/J ENSMUSG00220026536
 protein coding gene Chr14:44595355-44598570 (-)
BALB/cJ ENSMUSG00180051198
 protein coding gene Chr14:44890645-44893861 (-)
C3H/HeJ ENSMUSG00175048344
 protein coding gene Chr14:46579440-46582655 (-)
C57BL/6NJ ENSMUSG00215048304
 protein coding gene Chr14:44787491-44790706 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019334
 protein coding gene Chr14:47495381-47498232 (-)
CAST/EiJ ENSTCUG00005044761
 protein coding gene Chr14:46557751-46560970 (-)
CBA/J ENSMUSG00210041267
 protein coding gene Chr14:45259102-45262317 (-)
DBA/2J ENSMUSG00185052693
 protein coding gene Chr14:50372799-50376000 (-)
FVB/NJ ENSMUSG00205037475
 protein coding gene Chr14:44662754-44665969 (-)
JF1/MsJ ENSUMUG00000042846
 protein coding gene Chr14:61545931-61549146 (-)
LP/J ENSMUSG00230052569
 protein coding gene Chr14:62422518-62425733 (-)
NOD/ShiLtJ ENSMUSG00190040182
 protein coding gene Chr14:45025499-45028714 (-)
NZO/HlLtJ ENSMUSG00225045976
 protein coding gene Chr14:52712882-52716097 (-)
PWK/PhJ ENSLUMG00010039534
 protein coding gene Chr14:44482610-44485825 (-)
SPRET/EiJ ENSMSPG00010036504
 protein coding gene Chr14:47981521-47984714 (-)
WSB/EiJ ENSIUOG00005042882
 protein coding gene Chr14:44442188-44445401 (-)



Homology
more
  • Human Ortholog
    GZMB, granzyme B
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GZMB, granzyme B
  • Synonyms
    C11, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
  • Links
    NCBI Gene ID: 3002
    UniProt: P10144

  • Chr Location
    14q12; chr14:24630954-24634267 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    4
  • cDNA Data
    11
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079186 Ensembl Gene Model | MGI Sequence Detail 3216 C57BL/6J ±  kb
transcript ENSMUST00000015585 Ensembl | MGI Sequence Detail 894 Not Applicable  
polypeptide ENSMUSP00000015585 Ensembl | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 8
    cDNA 11
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-2235, MGD-MRK-38301, MGI:2145616
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:8216 Lobe CG, et al., Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1448-52
  • Latest
    J:378075 Fan H, et al., Partial embryo loss caused by disruption of the placental hormone CTRP6 coincides with dNK cell abnormalities during pregnancy. iScience. 2026 Jan 16;29(1):114434
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory