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Gzmc
Gene Detail
Symbol

Name
ID
Gzmc
granzyme C
MGI:109256
Synonyms
CCP2, Ctla5, Ctla-5
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr14:56231401-56234656 bp, - strand
From Ensembl annotation of GRCm38

  3256 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105844  Vertebrate Homology Class
1 mouse; 2 rat

Protein SuperFamily: trypsin
Gene Tree: Gzmc

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gzmc interacts with 26 markers (Mir22, Mir101a, Mir133b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cytolysis, granzyme-mediated apoptotic signaling pathway, ...
Component cytoplasm, intracellular membrane-bounded organelle
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(11)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(8) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000079186 (Evidence)
Entrez Gene 14940 (Evidence)
UniGene 14465
DFCI TC1586386
DoTS DT.101363199, DT.488880
EC 3.4.21.-
PDB 3FZZ, 3G01
Consensus CDS Project CCDS27146.1
International Mouse Phenotyping Consortium Status Gzmc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079186 Ensembl Gene Model | MGI Sequence Detail 3256 C57BL/6J ±  kb
transcript ENSMUST00000015585 Ensembl | MGI Sequence Detail 934 Not Applicable 
polypeptide ENSMUSP00000015585 Ensembl | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(87 from dbSNP Build 137)    SNPs within 2kb including multiple locations(91)
Protein-related
information
ResourceIDDescription
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000003487 granzyme C
References
(Earliest) J:8216 Lobe CG, et al., Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1448-52
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGD-MRK-2235, MGD-MRK-38301, MGI:2145616

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory