About   Help   FAQ
Gzmf
Gene Detail
Symbol

Name
ID
Gzmf
granzyme F
MGI:109254
Synonyms
CCP4, Ctla7, Ctla-7, CTL serine protease 3, granzyme G, MCSP-3
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr14:56205266-56211407 bp, - strand
From Ensembl annotation of GRCm38

  6142 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133275  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee

Protein SuperFamily: trypsin
Gene Tree: Gzmf

Human
homologs
Human Homolog GZMH, granzyme H (cathepsin G-like 2, protein h-CCPX)
NCBI Gene ID 2999
neXtProt AC  NX_P20718
Human Synonyms  CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
Human Chr (Location)  14q11.2; chr14:24606480-24609720 (-)  GRCh38
Interactions
Gzmf interacts with 29 markers (Mir22, Mir29c, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cytolysis, granzyme-mediated apoptotic signaling pathway, ...
Component membrane, secretory granule
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(7) cDNA(11) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000015441 (Evidence)
Entrez Gene14943 (Evidence)
UniGene457976
DFCITC1585608
DoTSDT.531640
EC3.4.21.-
Consensus CDS ProjectCCDS36936.1
International Mouse Knockout Project StatusGzmf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015441 Ensembl Gene Model | MGI Sequence Detail 6142 C57BL/6J ±  kb
transcript ENSMUST00000022757 Ensembl | MGI Sequence Detail 906 Not Applicable 
polypeptide ENSMUSP00000022757 Ensembl | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003493 granzyme F
References
(Earliest) J:21438 Jenne D, et al., Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4814-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)
Other
accession IDs
MGD-MRK-2227, MGD-MRK-2237, MGD-MRK-38299

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory