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Gzmf
Gene Detail
Symbol

Name
ID
Gzmf
granzyme F
MGI:109254
Synonyms
CCP4, Ctla7, Ctla-7, CTL serine protease 3, granzyme G, MCSP-3
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr14:56205266-56211407 bp, - strand
From Ensembl annotation of GRCm38

  6142 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133275  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee

HCOP human homology predictions: GZMH
Protein SuperFamily: trypsin
Gene Tree: Gzmf

Human
homologs
GZMH, granzyme H (cathepsin G-like 2, protein h-CCPX)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2999
neXtProt AC: NX_P20718

Human Synonyms: CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2

Human Chr (Location): 14q11.2; chr14:24606480-24609774 (-)  GRCh38.p2

Interactions
Gzmf interacts with 29 markers (Mir22, Mir29c, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cytolysis, granzyme-mediated apoptotic signaling pathway, ...
Component cytoplasm, intracellular membrane-bounded organelle, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (10)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(7) cDNA(11) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000015441 (Evidence)
Entrez Gene 14943 (Evidence)
UniGene 457976
DFCI TC1585608
DoTS DT.531640
EC 3.4.21.-
Consensus CDS Project CCDS36936.1
International Mouse Phenotyping Consortium Status Gzmf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015441 Ensembl Gene Model | MGI Sequence Detail 6142 C57BL/6J ±  kb
transcript ENSMUST00000022757 Ensembl | MGI Sequence Detail 906 Not Applicable 
polypeptide ENSMUSP00000022757 Ensembl | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003493 granzyme F
References
(Earliest) J:21438 Jenne D, et al., Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4814-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)
Other
accession IDs
MGD-MRK-2227, MGD-MRK-2237, MGD-MRK-38299

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory