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Gzmg
Gene Detail
Symbol

Name
ID
Gzmg
granzyme G
MGI:109253
Synonyms
Ctla7, Ctla-7
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:56156582-56159579 bp, - strand
From Ensembl annotation of GRCm38

  2998 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133275  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee

HCOP human homology predictions: GZMH
Protein SuperFamily: trypsin
Gene Tree: Gzmg

Human
homologs
GZMH, granzyme H (cathepsin G-like 2, protein h-CCPX)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2999
neXtProt AC: NX_P20718

Human Synonyms: CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2

Human Chr (Location): 14q11.2; chr14:24606480-24609774 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gzmg interacts with 31 markers (Mir18, Mir122, Mir129-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cytolysis, granzyme-mediated apoptotic signaling pathway, ...
Component cytoplasm, intracellular membrane-bounded organelle, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (27)    Tissues (23)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 4
RT-PCR 20
cDNA source data(13)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(13) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000040284 (Evidence)
Entrez Gene 14944 (Evidence)
UniGene 14868
DFCI TC1585737
DoTS DT.55274966
NIA Mouse Gene Index U035603
EC 3.4.21.-
Consensus CDS Project CCDS27144.1
International Mouse Phenotyping Consortium Status Gzmg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040284 Ensembl Gene Model | MGI Sequence Detail 2998 C57BL/6J ±  kb
transcript ENSMUST00000015578 Ensembl | MGI Sequence Detail 909 Not Applicable 
polypeptide ENSMUSP00000015578 Ensembl | MGI Sequence Detail 248 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(125 from dbSNP Build 137)    SNPs within 2kb including multiple locations(131)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003478 granzyme G
References
(Earliest) J:39247 Masson D, et al., A family of serine esterases in lytic granules of cytolytic T lymphocytes. Cell. 1987 Jun 5;49(5):679-85
(Latest) J:163833 Tsai TC, et al., Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition. BMC Dev Biol. 2010;10:88
All references(32)
Other
accession IDs
MGD-MRK-2237, MGD-MRK-38298

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory