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Sema4c
Gene Detail
Symbol

Name
ID
Sema4c
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
MGI:109252
Synonyms
M-Sema F, Semacl1, Semacl1, Semaf, Semai
Feature Type
protein coding gene
Genetic Map
Chromosome 1
15.32 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:36548642-36558349 bp, - strand
From Ensembl annotation of GRCm38

  9708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema4c

Human
homologs
Human Homolog SEMA4C, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
NCBI Gene ID 54910
neXtProt AC  NX_Q9C0C4
Human Synonyms  M-SEMA-F, SEMACL1, SEMAF, SEMAI
Human Chr (Location)  2q11.2; chr2:96859736-96869998 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation exhibit exencephaly, neonatal lethality, and abnormal cerebellum morphology.
 
Interactions
Sema4c interacts with 197 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell differentiation, cell migration in hindbrain, ...
Component cell junction, cytoplasmic vesicle, ...
Function protein binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (60)    Tissues (49)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 54
Northern blot 6
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(45)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026121 (Evidence)
Entrez Gene20353 (Evidence)
UniGene29558
NIA Mouse Gene IndexU021232
Consensus CDS ProjectCCDS48240.1
International Mouse Knockout Project StatusSema4c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026121 Ensembl Gene Model | MGI Sequence Detail 9708 C57BL/6J ±  kb
transcript ENSMUST00000114990 Ensembl | MGI Sequence Detail 3892 Not Applicable 
polypeptide ENSMUSP00000110641 Ensembl | MGI Sequence Detail 834 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(19) UniProt(4)
Polymorphisms
SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014624 semaphorin-4C
References
(Earliest) J:28378 Inagaki S, et al., Identification of a member of mouse semaphorin family. FEBS Lett. 1995 Aug 21;370(3):269-72
(Latest) J:185531 Wu H, et al., beta-Catenin gain of function in muscles impairs neuromuscular junction formation. Development. 2012 Jul;139(13):2392-404
All references(51)
Other
accession IDs
MGD-MRK-38297, MGI:2138227

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory