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Sema4c Gene Detail
Summary
  • Symbol
    Sema4c
  • Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
  • Synonyms
    M-Sema F, Semacl1, Semacl1, Semaf, Semai
  • Feature Type
    protein coding gene
  • IDs
    MGI:109252
    NCBI Gene: 20353
  • Gene Overview
    MyGene.info: SEMA4C
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36548639-36558349 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 15.32 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109252
protein coding gene Chr1:36548639-36558381 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015928
protein coding gene Chr1:35087092-35096802 (-)
A/J MGP_AJ_G0015912
protein coding gene Chr1:34146989-34156692 (-)
AKR/J MGP_AKRJ_G0015867
protein coding gene Chr1:34629443-34639147 (-)
BALB/cJ MGP_BALBcJ_G0015866
protein coding gene Chr1:33836648-33846358 (-)
C3H/HeJ MGP_C3HHeJ_G0015699
protein coding gene Chr1:34824774-34834477 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016319
protein coding gene Chr1:36674849-36684559 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014041
protein coding gene Chr1:31199786-31209676 (-)
CAST/EiJ MGP_CASTEiJ_G0015280
protein coding gene Chr1:34711454-34721178 (-)
CBA/J MGP_CBAJ_G0015671
protein coding gene Chr1:37630227-37639931 (-)
DBA/2J MGP_DBA2J_G0015772
protein coding gene Chr1:33482381-33492085 (-)
FVB/NJ MGP_FVBNJ_G0015774
protein coding gene Chr1:33005905-33015609 (-)
LP/J MGP_LPJ_G0015842
protein coding gene Chr1:35454779-35464489 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015794
protein coding gene Chr1:39856176-39865886 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016366
protein coding gene Chr1:34663523-34673227 (-)
PWK/PhJ MGP_PWKPhJ_G0015063
protein coding gene Chr1:33235193-33244943 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014845
protein coding gene Chr1:34613469-34623150 (-)
WSB/EiJ MGP_WSBEiJ_G0015342
protein coding gene Chr1:34613891-34623596 (-)



Homology
more
  • Human Ortholog
    SEMA4C, semaphorin 4C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SEMA4C, semaphorin 4C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    M-SEMA-F, SEMACL1, SEMAF, SEMAI
  • Links
    NCBI Gene ID: 54910
    neXtProt AC: NX_Q9C0C4
    UniProt: Q9C0C4

  • Chr Location
    2q11.2; chr2:96859736-96870943 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit exencephaly, neonatal lethality, and abnormal cerebellum morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026121 Ensembl Gene Model | MGI Sequence Detail 9711 C57BL/6J ±  kb
    transcript ENSMUST00000191677 Ensembl | MGI Sequence Detail 3779 Not Applicable  
    polypeptide ENSMUSP00000141263 Ensembl | MGI Sequence Detail 834 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38297, MGI:2138227
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 18
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:28378 Inagaki S, et al., Identification of a member of mouse semaphorin family. FEBS Lett. 1995 Aug 21;370(3):269-72
    • Latest
      J:263765 Xue D, et al., Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells. J Immunol. 2017 Jan 1;198(1):71-81

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory