Sema4c
Gene Detail

Symbol Name ID

Sema4c sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C MGI:109252

Synonyms

M-Sema F, Semacl1, Semacl1, Semaf, Semai

Feature Type

protein coding gene

Genetic Map

Chromosome 1

15.32 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:36548642-36558349 bp, - strand From VEGA annotation of GRCm38   9708 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema4c

Human homologs

Human Homolog		SEMA4C, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
NCBI Gene ID		54910
neXtProt AC		NX_Q9C0C4
Human Synonyms		M-SEMA-F, SEMACL1, SEMAF, SEMAI
Human Chr (Location)		2q11.2; chr2:97525473-97535735 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

Mice homozygous for a targeted mutation exhibit exencephaly, neonatal lethality, and abnormal cerebellum morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	cell differentiation, cell migration in hindbrain, ...
Component	cell junction, cytoplasmic vesicle, ...
Function	protein binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (60)    Tissues (47)    Images (3)
Theiler Stages: 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	54
Northern blot	6

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) cDNA(46)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020876 (Evidence)
Ensembl Gene Model	ENSMUSG00000026121 (Evidence)
Entrez Gene	20353 (Evidence)
UniGene	29558
NIA Mouse Gene Index	U021232
Consensus CDS Project	CCDS48240.1
International Mouse Knockout Project Status	Sema4c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020876	VEGA Gene Model | MGI Sequence Detail	9708	C57BL/6J
transcript	OTTMUST00000049354	VEGA | MGI Sequence Detail	3892	Not Applicable
polypeptide	OTTMUSP00000022847	VEGA | MGI Sequence Detail	834	Not Applicable

All sequences(49) RefSeq(3) UniProt(4)

Polymorphisms

SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR002165	Plexin
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014624	semaphorin-4C

References

(Earliest) J:28378 Inagaki S, et al., Identification of a member of mouse semaphorin family. FEBS Lett. 1995 Aug 21;370(3):269-72
(Latest) J:185531 Wu H, et al., beta-Catenin gain of function in muscles impairs neuromuscular junction formation. Development. 2012 Jul;139(13):2392-404
All references(51)

Other accession IDs

MGD-MRK-38297, MGI:2138227