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Chrm5 Gene Detail
Summary
  • Symbol
    Chrm5
  • Name
    cholinergic receptor, muscarinic 5
  • Synonyms
    M5R, muscarinic acetylcholine receptor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109248
    NCBI Gene: 213788
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr2:112479171-112480769 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 57.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    185 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109248
protein coding gene Chr2:112478733-112537470 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026292
protein coding gene Chr2:114930794-114932392 (-)
A/J MGP_AJ_G0026253
protein coding gene Chr2:110220331-110221929 (-)
AKR/J MGP_AKRJ_G0026232
protein coding gene Chr2:113327839-113329437 (-)
BALB/cJ MGP_BALBcJ_G0026266
protein coding gene Chr2:110485711-110487309 (-)
C3H/HeJ MGP_C3HHeJ_G0026011
protein coding gene Chr2:113706357-113707955 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026713
protein coding gene Chr2:118737185-118738783 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024093
protein coding gene Chr2:105456363-105457961 (-)
CAST/EiJ MGP_CASTEiJ_G0025474
protein coding gene Chr2:113979330-113980928 (-)
CBA/J MGP_CBAJ_G0025988
protein coding gene Chr2:122880805-122882403 (-)
DBA/2J MGP_DBA2J_G0026127
protein coding gene Chr2:109681500-109683098 (-)
FVB/NJ MGP_FVBNJ_G0026089
protein coding gene Chr2:108564856-108566454 (-)
LP/J MGP_LPJ_G0026228
protein coding gene Chr2:115225063-115226661 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026108
protein coding gene Chr2:127283008-127284606 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026768
protein coding gene Chr2:113385702-113387300 (-)
PWK/PhJ MGP_PWKPhJ_G0025210
protein coding gene Chr2:109185352-109186950 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025009
protein coding gene Chr2:112566379-112567977 (-)
WSB/EiJ MGP_WSBEiJ_G0025543
protein coding gene Chr2:114188787-114190385 (-)



Homology
more
  • Human Ortholog
    CHRM5, cholinergic receptor muscarinic 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHRM5, cholinergic receptor muscarinic 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HM5
  • Links
    NCBI Gene ID: 1133
    neXtProt AC: NX_P08912
    UniProt: P08912

  • Chr Location
    15q14; chr15:33968314-34065094 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null allele exhibit loss of acetylcholine-induced dilation of cerebral arteries, decreased pilocarpine-induced salivation, increased water-deprivation induced drinking, and attenuated morphine reinforcement and withdrawal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074939 Ensembl Gene Model | MGI Sequence Detail 1599 C57BL/6J ±  kb
transcript ENSMUST00000099589 Ensembl | MGI Sequence Detail 1599 Not Applicable  
polypeptide ENSMUSP00000097185 Ensembl | MGI Sequence Detail 532 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 1
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-38293
References
more
  • Summaries
    All 63
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 38
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory