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Chrm5 Gene Detail
Summary
  • Symbol
    Chrm5
  • Name
    cholinergic receptor, muscarinic 5
  • Synonyms
    M5R, muscarinic acetylcholine receptor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109248
    NCBI Gene: 213788
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr2:112309516-112311114 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 57.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109248
protein coding gene Chr2:112309078-112365491 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026292
protein coding gene Chr2:114930794-114932392 (-)
A/J MGP_AJ_G0026253
protein coding gene Chr2:110220331-110221929 (-)
AKR/J MGP_AKRJ_G0026232
protein coding gene Chr2:113327839-113329437 (-)
BALB/cJ MGP_BALBcJ_G0026266
protein coding gene Chr2:110485711-110487309 (-)
C3H/HeJ MGP_C3HHeJ_G0026011
protein coding gene Chr2:113706357-113707955 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026713
protein coding gene Chr2:118737185-118738783 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024093
protein coding gene Chr2:105456363-105457961 (-)
CAST/EiJ MGP_CASTEiJ_G0025474
protein coding gene Chr2:113979330-113980928 (-)
CBA/J MGP_CBAJ_G0025988
protein coding gene Chr2:122880805-122882403 (-)
DBA/2J MGP_DBA2J_G0026127
protein coding gene Chr2:109681500-109683098 (-)
FVB/NJ MGP_FVBNJ_G0026089
protein coding gene Chr2:108564856-108566454 (-)
LP/J MGP_LPJ_G0026228
protein coding gene Chr2:115225063-115226661 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026108
protein coding gene Chr2:127283008-127284606 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026768
protein coding gene Chr2:113385702-113387300 (-)
PWK/PhJ MGP_PWKPhJ_G0025210
protein coding gene Chr2:109185352-109186950 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025009
protein coding gene Chr2:112566379-112567977 (-)
WSB/EiJ MGP_WSBEiJ_G0025543
protein coding gene Chr2:114188787-114190385 (-)



Homology
more
  • Human Ortholog
    CHRM5, cholinergic receptor muscarinic 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRM5, cholinergic receptor muscarinic 5
  • Synonyms
    HM5
  • Links
    NCBI Gene ID: 1133
    neXtProt AC: NX_P08912
    UniProt: P08912

  • Chr Location
    15q14; chr15:33968497-34067458 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null allele exhibit loss of acetylcholine-induced dilation of cerebral arteries, decreased pilocarpine-induced salivation, increased water-deprivation induced drinking, and attenuated morphine reinforcement and withdrawal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074939 Ensembl Gene Model | MGI Sequence Detail 1599 C57BL/6J ±  kb
    transcript ENSMUST00000099589 Ensembl | MGI Sequence Detail 1599 Not Applicable  
    polypeptide ENSMUSP00000097185 Ensembl | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-38293
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 45
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:324534 Shindo Y, et al., A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development. Exp Cell Res. 2022 Jul 1;416(1):113137

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory