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Chrm5 Gene Detail
Summary
  • Symbol
    Chrm5
  • Name
    cholinergic receptor, muscarinic 5
  • Synonyms
    M5R, muscarinic acetylcholine receptor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109248
    NCBI Gene: 213788
Location & Maps
more
  • Sequence Map
    Chr2:112479171-112480769 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1599 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 57.02 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CHRM5, cholinergic receptor muscarinic 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHRM5, cholinergic receptor muscarinic 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HM5
  • Links
    NCBI Gene ID: 1133
    neXtProt AC: NX_P08912

  • Chr Location
    15q14; chr15:33968245-34065094 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    2 involving Chrm5
  • Incidental Mutations
Homozygotes for a targeted null allele exhibit loss of acetylcholine-induced dilation of cerebral arteries, decreased pilocarpine-induced salivation, increased water-deprivation induced drinking, and attenuated morphine reinforcement and withdrawal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015145 VEGA Gene Model | MGI Sequence Detail 1599 C57BL/6J ±  kb
transcript OTTMUST00000035927 VEGA | MGI Sequence Detail 1599 Not Applicable  
polypeptide OTTMUSP00000016127 VEGA | MGI Sequence Detail 532 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    185 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 5
    Primer pair 1
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-38293
References
more
  • Summaries
    All 58
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 38
  • Earliest
    J:26554 Lammerding-Koppel M, et al., Muscarinic receptors in the prenatal mouse embryo. Comparison of M35-immunohistochemistry with [3H]quinuclidinyl benzylate autoradiography. Histochem Cell Biol. 1995 Apr;103(4):301-10
  • Latest
    J:214125 Chen SR, et al., Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem. 2014 May 16;289(20):14321-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory