Ddit3
Gene Detail

Symbol Name ID

Ddit3 DNA-damage inducible transcript 3 MGI:109247

Synonyms

C/EBP homoologous protein 10, chop, CHOP10, CHOP-10, gadd153

Feature Type

protein coding gene

Genetic Map

Chromosome 10

74.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:127290774-127296288 bp, + strand From VEGA annotation of GRCm38   5515 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3012  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: C/EBP-zeta (C/EBP-homologous protein)
Gene Tree: Ddit3

Human homologs

Human Homolog		DDIT3, DNA-damage-inducible transcript 3
NCBI Gene ID		1649
neXtProt AC		NX_P35638
Human Synonyms		CEBPZ, CHOP, CHOP10, CHOP-10, GADD153
Human Chr (Location)		12q13.1-q13.2; chr12:57910371-57914300 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DDIT3

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(10)
 

Mice homozygous for a knock-out allele exhibit decreased apoptosis in different cell types.

 

Gene Ontology (GO) classifications

All GO classifications: (56 annotations)

Process	apoptotic process, blood vessel maturation, ...
Component	cytoplasm, late endosome, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (165)    Tissues (145)    Images (19)
Theiler Stages: 17, 19, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	154
Western blot	4
RT-PCR	7

cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) Genomic(1) cDNA(53) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000032537 (Evidence)
Ensembl Gene Model	ENSMUSG00000025408 (Evidence)
Entrez Gene	13198 (Evidence)
UniGene	110220
DFCI	TC1579825, TC1616125
DoTS	DT.94274686, DT.94276268
NIA Mouse Gene Index	U012145
Consensus CDS Project	CCDS24236.1
International Mouse Knockout Project Status	Ddit3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032537	VEGA Gene Model | MGI Sequence Detail	5515	C57BL/6J
transcript	OTTMUST00000080968	VEGA | MGI Sequence Detail	890	Not Applicable
polypeptide	OTTMUSP00000043195	VEGA | MGI Sequence Detail	168	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR016670	DNA damage-inducible transcript 3
Protein Ontology	PR:000006347	DNA damage-inducible transcript 3 protein

References

(Earliest) J:38292 Ron D, et al., CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992 Mar;6(3):439-53
(Latest) J:193184 Esposito V, et al., CHOP deficiency results in elevated lipopolysaccharide-induced inflammation and kidney injury. Am J Physiol Renal Physiol. 2013 Feb;304(4):F440-50
All references(117)

Other accession IDs

MGD-MRK-38292