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Ddit3
Gene Detail
Symbol

Name
ID
Ddit3
DNA-damage inducible transcript 3
MGI:109247
Synonyms
C/EBP homoologous protein 10, chop, CHOP10, CHOP-10, gadd153
Feature Type
protein coding gene
Genetic Map
Chromosome 10
74.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:127290774-127296288 bp, + strand
From VEGA annotation of GRCm38

  5515 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3012  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: DDIT3
Protein SuperFamily: C/EBP-zeta (C/EBP-homologous protein)
Gene Tree: Ddit3

Human
homologs
DDIT3, DNA-damage-inducible transcript 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1649
neXtProt AC: NX_P35638

Human Synonyms: CEBPZ, CHOP, CHOP10, CHOP-10, GADD153

Human Chr (Location): 12q13.1-q13.2; chr12:57516588-57521698 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DDIT3

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(10) Targeted(7) Transgenic(1)
 
Mice homozygous for a knock-out allele exhibit decreased apoptosis in different cell types.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Ddit3 interacts with 31 markers (Mir1b, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (99 annotations)
Process apoptotic process, blood vessel maturation, ...
Component AP1 complex, cell, ...
Function cAMP response element binding protein binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (165)    Tissues (148)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 154
Western blot 4
RT-PCR 7
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ddit3 ; ZFIN ddit3    NEW 
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(52) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000032537 (Evidence)
Ensembl Gene Model ENSMUSG00000025408 (Evidence)
Entrez Gene 13198 (Evidence)
UniGene 110220
DFCI TC1579825, TC1616125
DoTS DT.94274686, DT.94276268
NIA Mouse Gene Index U012145
Consensus CDS Project CCDS24236.1
International Mouse Phenotyping Consortium Status Ddit3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032537 VEGA Gene Model | MGI Sequence Detail 5515 C57BL/6J ±  kb
transcript OTTMUST00000080968 VEGA | MGI Sequence Detail 890 Not Applicable 
polypeptide OTTMUSP00000043195 VEGA | MGI Sequence Detail 168 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR016670 DNA damage-inducible transcript 3
Protein Ontology PR:000006347 DNA damage-inducible transcript 3 protein
References
(Earliest) J:38292 Ron D, et al., CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992 Mar;6(3):439-53
(Latest) J:222977 Jia LX, et al., Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection. J Pathol. 2015 Jul;236(3):373-83
All references(155)
Other
accession IDs
MGD-MRK-38292

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory