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Ddit3 Gene Detail
Summary
  • Symbol
    Ddit3
  • Name
    DNA-damage inducible transcript 3
  • Synonyms
    C/EBP homoologous protein 10, chop, CHOP10, CHOP-10, gadd153
  • Feature Type
    protein coding gene
  • IDs
    MGI:109247
    NCBI Gene: 13198
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127290793-127296291 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109247
protein coding gene Chr10:127290774-127296291 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017816
protein coding gene Chr10:130881140-130886654 (+)
A/J MGP_AJ_G0017791
protein coding gene Chr10:125636133-125641647 (+)
AKR/J MGP_AKRJ_G0017754
protein coding gene Chr10:129352173-129357685 (+)
BALB/cJ MGP_BALBcJ_G0017755
protein coding gene Chr10:126047933-126053447 (+)
C3H/HeJ MGP_C3HHeJ_G0017579
protein coding gene Chr10:129503336-129508849 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018210
protein coding gene Chr10:135316972-135322486 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015890
protein coding gene Chr10:119644979-119650289 (+)
CAST/EiJ MGP_CASTEiJ_G0017139
protein coding gene Chr10:130162163-130167581 (+)
CBA/J MGP_CBAJ_G0017548
protein coding gene Chr10:140768469-140773982 (+)
DBA/2J MGP_DBA2J_G0017654
protein coding gene Chr10:124728605-124734120 (+)
FVB/NJ MGP_FVBNJ_G0017649
protein coding gene Chr10:123669216-123674731 (+)
LP/J MGP_LPJ_G0017728
protein coding gene Chr10:131451327-131456842 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017677
protein coding gene Chr10:143471952-143477467 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018250
protein coding gene Chr10:129416871-129422385 (+)
PWK/PhJ MGP_PWKPhJ_G0016924
protein coding gene Chr10:124931777-124937259 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016716
protein coding gene Chr10:128455853-128461251 (+)
WSB/EiJ MGP_WSBEiJ_G0017200
protein coding gene Chr10:129647069-129652583 (+)



Homology
more
  • Human Ortholog
    DDIT3, DNA damage inducible transcript 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DDIT3, DNA damage inducible transcript 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AltDDIT3, CEBPZ, C/EBPzeta, CHOP, CHOP10, CHOP-10, GADD153
  • Links
    NCBI Gene ID: 1649
    neXtProt AC: NX_P35638
    UniProt: P0DPQ6, P35638

  • Chr Location
    12q13.3; chr12:57516588-57520517 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DDIT3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 7 genetic backgrounds
    13 phenotypes from multigenic genotypes
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased apoptosis in different cell types.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13198 NCBI Gene Model | MGI Sequence Detail 5499 C57BL/6J ±  kb
    transcript NM_007837 RefSeq | MGI Sequence Detail 888 Not Specified  
    polypeptide P35639 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 1
      cDNA 53
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38292
    References
    more
    • Summaries
      All 226
      Developmental Gene Expression 48
      Diseases 1
      Gene Ontology 26
      Phenotypes 100
    • Earliest
      J:38292 Ron D, et al., CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992 Mar;6(3):439-53
    • Latest
      J:265800 Shiozaki Y, et al., The CDK 9-cyclin T1 complex mediates saturated fatty acid-induced vascular calcification by inducing expression of the transcription factor CHOP. J Biol Chem. 2018 Sep 12;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory