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Ddit3
Gene Detail
 Symbol
Name
ID
Ddit3
DNA-damage inducible transcript 3
MGI:109247
Synonyms C/EBP homoologous protein 10, chop, CHOP10, CHOP-10, gadd153
Feature Type protein coding gene
Genetic Map
Chromosome 10
74.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:127290774-127296288 bp, + strand
From VEGA annotation of GRCm38

  5515 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3012  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: C/EBP-zeta (C/EBP-homologous protein)
Gene Tree: Ddit3

Human
homologs
Human Homolog DDIT3, DNA-damage-inducible transcript 3
NCBI Gene ID 1649
neXtProt AC  NX_P35638
Human Synonyms  CEBPZ, CHOP, CHOP10, CHOP-10, GADD153
Human Chr (Location)  12q13.1-q13.2; chr12:57516588-57520517 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DDIT3
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(10) Targeted(7)
 
Mice homozygous for a knock-out allele exhibit decreased apoptosis in different cell types.
 
Interactions
Ddit3 interacts with 31 markers (Mir1b, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process apoptotic process, blood vessel maturation, ...
Component cell, cytoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (165)    Tissues (145)    Images (19)
Theiler Stages: 17, 19, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 154
Western blot 4
RT-PCR 7
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(52) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000032537 (Evidence)
Ensembl Gene ModelENSMUSG00000025408 (Evidence)
Entrez Gene13198 (Evidence)
UniGene110220
DFCITC1579825, TC1616125
DoTSDT.94274686, DT.94276268
NIA Mouse Gene IndexU012145
Consensus CDS ProjectCCDS24236.1
International Mouse Knockout Project StatusDdit3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032537 VEGA Gene Model | MGI Sequence Detail 5515 C57BL/6J ±  kb
transcript OTTMUST00000080968 VEGA | MGI Sequence Detail 890 Not Applicable 
polypeptide OTTMUSP00000043195 VEGA | MGI Sequence Detail 168 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR016670 DNA damage-inducible transcript 3
Protein Ontology PR:000006347 DNA damage-inducible transcript 3 protein
References (Earliest) J:38292 Ron D, et al., CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992 Mar;6(3):439-53
(Latest) J:209937 Shenderov K, et al., Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1beta in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway. J Immunol. 2014 Mar 1;192(5):2029-33
All references(133)
Other
accession IDs
MGD-MRK-38292

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory