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Ddit3 Gene Detail
Summary
  • Symbol
    Ddit3
  • Name
    DNA-damage inducible transcript 3
  • Synonyms
    C/EBP homoologous protein 10, chop, CHOP10, CHOP-10, gadd153
  • Feature Type
    protein coding gene
  • IDs
    MGI:109247
    NCBI Gene: 13198
Location & Maps
more
  • Sequence Map
    Chr10:127290774-127296288 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5515 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DDIT3, DNA damage inducible transcript 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DDIT3, DNA damage inducible transcript 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CEBPZ, CHOP, CHOP10, CHOP-10, GADD153
  • Links
    NCBI Gene ID: 1649
    neXtProt AC: NX_P35638

  • Chr Location
    12q13.1-q13.2; chr12:57516588-57521698 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DDIT3 associations

Human Disease Mouse Models
       Myxoid Liposarcoma   OMIM: 613488 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    10
  • Targeted
    7
  • Transgenic
    2
Mice homozygous for a knock-out allele exhibit decreased apoptosis in different cell types.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032537 VEGA Gene Model | MGI Sequence Detail 5515 C57BL/6J ±  kb
transcript OTTMUST00000080968 VEGA | MGI Sequence Detail 890 Not Applicable  
polypeptide OTTMUSP00000043195 VEGA | MGI Sequence Detail 168 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006347 DNA damage-inducible transcript 3 protein
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR016670 DNA damage-inducible transcript 3
Molecular
Reagents
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  • All nucleic 56
    Genomic 1
    cDNA 52
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38292
References
more
  • Summaries
    All 154
    Developmental Gene Expression 33
    Diseases 1
    Gene Ontology 22
    Phenotypes 69
  • Earliest
    J:38292 Ron D, et al., CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992 Mar;6(3):439-53
  • Latest
    J:226104 Wang F, et al., ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development. Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E487-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory