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Sema4d
Gene Detail
Symbol

Name
ID
Sema4d
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
MGI:109244
Synonyms
CD100, coll-4, M-sema G, Semacl2, Semaj, semaphorin H, Semcl2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
26.16 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:51701246-51793747 bp, - strand
From VEGA annotation of GRCm38

  92502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SEMA4D
Gene Tree: Sema4d

Human
homologs
SEMA4D, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10507
neXtProt AC: NX_Q92854

Human Synonyms: C9orf164, CD100, coll-4, M-sema-G, SEMAJ

Human Chr (Location): 9q22.2; chr9:89360791-89498014 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(60) : Gene trapped(56) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display functional defects in their immune system but are normal in other systems of the body.
 
Interactions
Sema4d interacts with 198 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cell differentiation, leukocyte aggregation, ...
Component extracellular space, integral component of membrane, ...
Function receptor activity, receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (80)    Tissues (58)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 66
Western blot 4
RNase protection 10
cDNA source data(97)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sema4d    NEW 
Molecular
reagents
All nucleic(99) cDNA(97) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020953 (Evidence)
Ensembl Gene Model ENSMUSG00000021451 (Evidence)
Entrez Gene 20354 (Evidence)
UniGene 33903
DFCI TC1572823
DoTS DT.87060858, DT.101387828, DT.110959699, DT.97397890
NIA Mouse Gene Index U034777
Consensus CDS Project CCDS26514.1
International Mouse Phenotyping Consortium Status Sema4d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020953 VEGA Gene Model | MGI Sequence Detail 92502 C57BL/6J ±  kb
transcript OTTMUST00000049521 VEGA | MGI Sequence Detail 4472 Not Applicable 
polypeptide OTTMUSP00000022963 VEGA | MGI Sequence Detail 861 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(20) UniProt(2)
Polymorphisms
SNPs within 2kb(416 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000002084 semaphorin-4D
References
(Earliest) J:37313 Furuyama T, et al., Identification of a novel transmembrane semaphorin expressed on lymphocytes. J Biol Chem. 1996 Dec 27;271(52):33376-81
(Latest) J:217348 Ito T, et al., Estrogen-dependent proteolytic cleavage of semaphorin 4D and plexin-B1 enhances semaphorin 4D-induced apoptosis during postnatal vaginal remodeling in pubescent mice. PLoS One. 2014;9(5):e97909
All references(67)
Other
accession IDs
MGD-MRK-38289, MGI:895064

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory