Sema4d
Gene Detail

Symbol Name ID

Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D MGI:109244

Synonyms

CD100, coll-4, M-sema G, Semacl2, Semaj, semaphorin H, Semcl2

Feature Type

protein coding gene

Genetic Map

Chromosome 13

26.16 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr13:51701246-51793747 bp, - strand From VEGA annotation of GRCm38   92502 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sema4d

Human homologs

Human Homolog		SEMA4D, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
NCBI Gene ID		10507
neXtProt AC		NX_Q92854
Human Synonyms		C9orf164, CD100, coll-4, M-sema-G, SEMAJ
Human Chr (Location)		9q22.2; chr9:91975706-92094611 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(60) : Targeted(4) Gene trapped(56)
 

Mice homozygous for disruptions in this gene display functional defects in their immune system but are normal in other systems of the body.

 

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	cell differentiation, leukocyte aggregation, ...
Component	extracellular space, integral to membrane, ...
Function	receptor activity, receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (80)    Tissues (58)    Images (30)
Theiler Stages: 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	66
Western blot	4
RNase protection	10

cDNA source data(99)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(101) cDNA(99) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000020953 (Evidence)
Ensembl Gene Model	ENSMUSG00000021451 (Evidence)
Entrez Gene	20354 (Evidence)
UniGene	33903
DFCI	TC1572823
DoTS	DT.101387828, DT.110959699, DT.87060858, DT.97397890
NIA Mouse Gene Index	U034777
Consensus CDS Project	CCDS26514.1
International Mouse Knockout Project Status	Sema4d

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020953	VEGA Gene Model | MGI Sequence Detail	92502	C57BL/6J
transcript	OTTMUST00000049522	VEGA | MGI Sequence Detail	4482	Not Applicable
polypeptide	OTTMUSP00000022964	VEGA | MGI Sequence Detail	861	Not Applicable

All sequences(52) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(398 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR002165	Plexin
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR027231	Semaphorin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000002084	semaphorin-4D

References

(Earliest) J:37313 Furuyama T, et al., Identification of a novel transmembrane semaphorin expressed on lymphocytes. J Biol Chem. 1996 Dec 27;271(52):33376-81
(Latest) J:194755 Stalker TJ, et al., Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood. 2013 Mar 7;121(10):1875-85
All references(66)

Other accession IDs

MGD-MRK-38289, MGI:895064