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Sema4d Gene Detail
Summary
  • Symbol
    Sema4d
  • Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
  • Synonyms
    CD100, coll-4, M-sema G, Semacl2, Semaj, semaphorin H, Semcl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109244
    NCBI Gene: 20354
  • Gene Overview
    MyGene.info: SEMA4D
Location & Maps
more
  • Sequence Map
    Chr13:51701246-51793747 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      92502 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.16 cM, cytoband B1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SEMA4D, semaphorin 4D
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SEMA4D, semaphorin 4D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C9orf164, CD100, coll-4, M-sema-G, SEMAJ
  • Links
    NCBI Gene ID: 10507
    neXtProt AC: NX_Q92854

  • Chr Location
    9q22.2; chr9:89360791-89498014 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    62
  • Chemically induced (other)
    1
  • Gene trapped
    56
  • Targeted
    5
  • Genomic Mutations
    1 involving Sema4d
  • Incidental Mutations
Mice homozygous for disruptions in this gene display functional defects in their immune system but are normal in other systems of the body.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020953 VEGA Gene Model | MGI Sequence Detail 92502 C57BL/6J ±  kb
transcript OTTMUST00000049521 VEGA | MGI Sequence Detail 4472 Not Applicable  
polypeptide OTTMUSP00000022963 VEGA | MGI Sequence Detail 861 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    486 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 100
    cDNA 98
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38289, MGI:895064
References
more
  • Summaries
    All 70
    Developmental Gene Expression 18
    Gene Ontology 5
    Phenotypes 31
  • Earliest
    J:37313 Furuyama T, et al., Identification of a novel transmembrane semaphorin expressed on lymphocytes. J Biol Chem. 1996 Dec 27;271(52):33376-81
  • Latest
    J:226045 Sawano T, et al., Effect of Sema4D on microglial function in middle cerebral artery occlusion mice. Glia. 2015 Dec;63(12):2249-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory