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St8sia5 Gene Detail
Summary
  • Symbol
    St8sia5
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
  • Synonyms
    Siat8e, ST8SiaV
  • Feature Type
    protein coding gene
  • IDs
    MGI:109243
    NCBI Gene: 225742
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:77273529-77343146 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109243
 protein coding gene Chr18:77273529-77346467 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024574
 protein coding gene Chr18:77922097-78002268 (+)
A/J MGP_AJ_G0024541
 protein coding gene Chr18:74529013-74608928 (+)
AKR/J MGP_AKRJ_G0024512
 protein coding gene Chr18:76721095-76789942 (+)
BALB/cJ MGP_BALBcJ_G0024540
 protein coding gene Chr18:74741329-74813218 (+)
C3H/HeJ MGP_C3HHeJ_G0024309
 protein coding gene Chr18:76830212-76909922 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024987
 protein coding gene Chr18:79978721-80054998 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022417
 protein coding gene Chr18:73538375-73606605 (+)
CAST/EiJ MGP_CASTEiJ_G0023781
 protein coding gene Chr18:77114460-77191309 (+)
CBA/J MGP_CBAJ_G0024278
 protein coding gene Chr18:82793308-82874955 (+)
DBA/2J MGP_DBA2J_G0024408
 protein coding gene Chr18:74104976-74175400 (+)
FVB/NJ MGP_FVBNJ_G0024374
 protein coding gene Chr18:73456127-73528006 (+)
LP/J MGP_LPJ_G0024492
 protein coding gene Chr18:77811380-77891398 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024404
 protein coding gene Chr18:84082719-84160980 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025035
 protein coding gene Chr18:76888573-76960409 (+)
PWK/PhJ MGP_PWKPhJ_G0023526
 protein coding gene Chr18:74520751-74591870 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023330
 protein coding gene Chr18:77076171-77153607 (+)
WSB/EiJ MGP_WSBEiJ_G0023845
 protein coding gene Chr18:76844263-76922161 (+)



Homology
more
  • Human Ortholog
    ST8SIA5, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST8SIA5, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
  • Synonyms
    SIAT8-E, SIAT8E, ST8SiaV
  • Links
    NCBI Gene ID: 29906
    UniProt: O15466

  • Chr Location
    18q21.1; chr18:46667821-46759257 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    112
  • cDNA Data
    10
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 225742 NCBI Gene Model | MGI Sequence Detail 69618 C57BL/6J ±  kb
transcript NM_013666 RefSeq | MGI Sequence Detail 2115 C57BL/6  
polypeptide P70126 UniProt | EBI | MGI Sequence Detail 412 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38288
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 3
  • Earliest
    J:36726 Kono M, et al., Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3. J Biol Chem. 1996 Nov 15;271(46):29366-71
  • Latest
    J:183442 Kwak DH, et al., Regulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells. BMB Rep. 2011 Dec;44(12):799-804
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory