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St8sia5 Gene Detail
Summary
  • Symbol
    St8sia5
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
  • Synonyms
    Siat8e, ST8SiaV
  • Feature Type
    protein coding gene
  • IDs
    MGI:109243
    NCBI Gene: 225742
Location & Maps
more
  • Sequence Map
    Chr18:77185853-77255450 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      69598 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.13 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ST8SIA5, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ST8SIA5, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIAT8E, SIAT8-E, ST8SiaV
  • Links
    NCBI Gene ID: 29906
    neXtProt AC: NX_O15466

  • Chr Location
    18q21.1; chr18:46679118-46757169 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    3
  • Gene trapped
    2
  • Transposon induced
    1
  • Genomic Mutations
    1 involving St8sia5
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    114
  • Tissues
    112
  • cDNA Data
    9
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028209 VEGA Gene Model | MGI Sequence Detail 69598 C57BL/6J ±  kb
transcript OTTMUST00000069886 VEGA | MGI Sequence Detail 1841 Not Applicable  
polypeptide OTTMUSP00000035553 VEGA | MGI Sequence Detail 412 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    412 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38288
References
more
  • Summaries
    All 28
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:36726 Kono M, et al., Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3. J Biol Chem. 1996 Nov 15;271(46):29366-71
  • Latest
    J:183442 Kwak DH, et al., Regulatory roles of ganglioside GQ1b in neuronal cell differentiation of mouse embryonic stem cells. BMB Rep. 2011 Dec;44(12):799-804
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory