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Tead3
Gene Detail
Symbol

Name
ID
Tead3
TEA domain family member 3
MGI:109241
Synonyms
DTEF-1, ETFR-1, Tcf13r2, TEAD-3, TEF-5
Feature Type
protein coding gene
Genetic Map
Chromosome 17
14.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:28331671-28350805 bp, - strand
From VEGA annotation of GRCm38

  19135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TEAD3
Protein SuperFamily: transcriptional enhancer factor
Gene Tree: Tead3

Human
homologs
TEAD3, TEA domain family member 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7005
neXtProt AC: NX_Q99594

Human Synonyms: DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF5, TEF-5

Human Chr (Location): 6p21.2; chr6:35473597-35497084 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(8) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Tead3 interacts with 176 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process hippo signaling, positive regulation of stem cell maintenance, ...
Component intracellular, nucleus, ...
Function DNA binding, RNA polymerase II transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (265)    Tissues (155)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 227
Northern blot 24
RT-PCR 14
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tead3a    NEW 
Molecular
reagents
All nucleic(71) Genomic(2) cDNA(65) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024245 (Evidence)
Ensembl Gene Model ENSMUSG00000002249 (Evidence)
Entrez Gene 21678 (Evidence)
UniGene 6655
DFCI TC1703873, TC1599264, TC1593335, TC1582768
DoTS DT.101314017, DT.99765265, DT.529425, DT.101740833, DT.99765219, DT.97400630, DT.91446713
NIA Mouse Gene Index U037605
Consensus CDS Project CCDS28577.3, CCDS50046.1
International Mouse Phenotyping Consortium Status Tead3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024245 VEGA Gene Model | MGI Sequence Detail 19135 C57BL/6J ±  kb
transcript OTTMUST00000059334 VEGA | MGI Sequence Detail 2448 Not Applicable 
polypeptide OTTMUSP00000028855 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000818 TEA/ATTS
InterPro IPR016361 Transcriptional enhancer factor
InterPro IPR027253 Transcriptional enhancer factor TEF-5 (TEAD3)
Protein Ontology PR:000016220 transcriptional enhancer factor TEF-5
References
(Earliest) J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
(Latest) J:184824 Liu-Chittenden Y, et al., Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 2012 Jun 15;26(12):1300-5
All references(55)
Other
accession IDs
MGD-MRK-38286, MGI:2147049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory