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Tead3
Gene Detail
 Symbol
Name
ID
Tead3
TEA domain family member 3
MGI:109241
Synonyms DTEF-1, ETFR-1, Tcf13r2, TEAD-3, TEF-5
Feature Type protein coding gene
Genetic Map
Chromosome 17
14.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:28331671-28350805 bp, - strand
From VEGA annotation of GRCm38

  19135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcriptional enhancer factor
Gene Tree: Tead3

Human
homologs
Human Homolog TEAD3, TEA domain family member 3
NCBI Gene ID 7005
neXtProt AC  NX_Q99594
Human Synonyms  DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF5, TEF-5
Human Chr (Location)  6p21.2; chr6:35473597-35497084 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(8) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tead3 interacts with 176 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process hippo signaling, positive regulation of transcription from RNA polymerase II promoter, ...
Component intracellular, nucleus, ...
Function DNA binding, RNA polymerase II transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (195)    Tissues (99)    Images (14)
Theiler Stages: 1, 2, 3, 4, 5, 10, 12, 14, 15, 16, 17, 19, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 157
Northern blot 24
RT-PCR 14
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) Genomic(2) cDNA(64) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024245 (Evidence)
Ensembl Gene ModelENSMUSG00000002249 (Evidence)
Entrez Gene21678 (Evidence)
UniGene6655
DFCITC1582768, TC1593335, TC1599264, TC1703873
DoTSDT.101314017, DT.101740833, DT.529425, DT.91446713, DT.97400630, DT.99765219, DT.99765265
NIA Mouse Gene IndexU037605
Consensus CDS ProjectCCDS28577.3, CCDS50046.1
International Mouse Knockout Project StatusTead3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024245 VEGA Gene Model | MGI Sequence Detail 19135 C57BL/6J ±  kb
transcript OTTMUST00000059334 VEGA | MGI Sequence Detail 2448 Not Applicable 
polypeptide OTTMUSP00000028855 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(6) UniProt(8)
Polymorphisms RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000818 TEA/ATTS
InterPro IPR016361 Transcriptional enhancer factor
InterPro IPR027253 Transcriptional enhancer factor TEF-5 (TEAD3)
Protein Ontology PR:000016220 transcriptional enhancer factor TEF-5
References (Earliest) J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
(Latest) J:184824 Liu-Chittenden Y, et al., Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 2012 Jun 15;26(12):1300-5
All references(55)
Other
accession IDs
MGD-MRK-38286, MGI:2147049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory