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Ube2l3
Gene Detail
Symbol

Name
ID
Ube2l3
ubiquitin-conjugating enzyme E2L 3
MGI:109240
Synonyms
Ubce7, UbcM4
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:17152013-17202649 bp, - strand
From VEGA annotation of GRCm38

  50637 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:43226  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UBE2L3
Protein SuperFamily: ubiquitin-conjugating enzyme E2
Gene Tree: Ube2l3

Human
homologs
UBE2L3, ubiquitin-conjugating enzyme E2L 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7332
neXtProt AC: NX_P68036

Human Synonyms: E2-F1, L-UBC, UBCH7, UbcM4

Human Chr (Location): 22q11.21; chr22:21549447-21624034 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(171) : Gene trapped(170) Transgenic(1)
 
A portion of hypomorphic embyros die before birth while those that survive are growth retarded and do not survive past the first day of life. The embryonic and perinatal lethality are attributed to defective placental development.
 
Interactions
Ube2l3 interacts with 227 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell cycle phase transition, cell proliferation, ...
Component cytoplasm, extracellular exosome, ...
Function poly(A) RNA binding, transcription coactivator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (55)    Tissues (19)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 55
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ube2l3 ; ZFIN ube2l3a, ube2l3b    NEW 
Molecular
reagents
All nucleic(29) Genomic(8) cDNA(21)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000025066 (Evidence)
Ensembl Gene Model ENSMUSG00000038965 (Evidence)
Entrez Gene 22195 (Evidence)
DFCI TC1573162
DoTS DT.94345283, DT.55101245, DT.101159533
Consensus CDS Project CCDS27997.1
International Mouse Phenotyping Consortium Status Ube2l3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025066 VEGA Gene Model | MGI Sequence Detail 50637 C57BL/6J ±  kb
transcript OTTMUST00000061185 VEGA | MGI Sequence Detail 2906 Not Applicable 
polypeptide OTTMUSP00000029959 VEGA | MGI Sequence Detail 154 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000032616 ubiquitin-conjugating enzyme E2 L3
References
(Earliest) J:31581 Matuschewski K, et al., Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions. J Biol Chem. 1996 Feb 2;271(5):2789-94
(Latest) J:198126 Lee PC, et al., Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell. 2013 Apr 25;50(2):172-84
All references(34)
Other
accession IDs
MGD-MRK-38285, MGI:2146706

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory