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Kcnab2 Gene Detail
Summary
  • Symbol
    Kcnab2
  • Name
    potassium voltage-gated channel, shaker-related subfamily, beta member 2
  • Synonyms
    F5, I2rf5, I2rf5, Kcnb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109239
    NCBI Gene: 16498
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152475201-152561991 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 83.08 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2956 from dbSNP Build 142
  • Strain Annotations
    31
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109239
 protein coding gene Chr4:152475199-152562367 (-)
129S1/SvImJ ENSMUSGG00200054882
 protein coding gene Chr4:143585650-143586801 (-)
129S1/SvImJ ENSMUSG00200018533
 protein coding gene Chr4:143543554-143576709 (-)
A/J ENSMUSGG00195054989
 protein coding gene Chr4:145221528-145222680 (-)
A/J ENSMUSG00195016284
 protein coding gene Chr4:145177493-145212581 (-)
AKR/J ENSMUSG00220025522
 protein coding gene Chr4:144764008-144799103 (-)
AKR/J ENSMUSGG00220054832
 protein coding gene Chr4:144808050-144809202 (-)
BALB/cJ ENSMUSG00180002314
 protein coding gene Chr4:142859682-142894770 (-)
BALB/cJ ENSMUSGG00180055436
 protein coding gene Chr4:142903715-142904867 (-)
C3H/HeJ ENSMUSGG00175054718
 protein coding gene Chr4:146188583-146189735 (-)
C3H/HeJ ENSMUSG00175017516
 protein coding gene Chr4:146144553-146179642 (-)
C57BL/6NJ ENSMUSGG00215055716
 protein coding gene Chr4:145032165-145033317 (-)
C57BL/6NJ ENSMUSG00215007383
 protein coding gene Chr4:144988134-145023222 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026858
 protein coding gene Chr4:142290736-142378603 (-)
CAST/EiJ ENSTCUG00005028847
 protein coding gene Chr4:148862407-148897648 (-)
CBA/J ENSMUSGG00210054720
 protein coding gene Chr4:144840254-144841406 (-)
CBA/J ENSMUSG00210005668
 protein coding gene Chr4:144796222-144831309 (-)
DBA/2J ENSMUSG00185016577
 protein coding gene Chr4:148361138-148396226 (-)
DBA/2J ENSMUSGG00185057520
 protein coding gene Chr4:148405169-148406321 (-)
FVB/NJ ENSMUSG00205014740
 protein coding gene Chr4:143257725-143292814 (-)
FVB/NJ ENSMUSGG00205054470
 protein coding gene Chr4:143301759-143302911 (-)
JF1/MsJ ENSUMUG00000005415
 protein coding gene Chr4:151391120-151424187 (-)
LP/J ENSMUSG00230018421
 protein coding gene Chr4:155094284-155129371 (-)
LP/J ENSMUSGG00230055469
 protein coding gene Chr4:155138314-155139466 (-)
NOD/ShiLtJ ENSMUSGG00190054660
 protein coding gene Chr4:144504411-144505563 (-)
NOD/ShiLtJ ENSMUSG00190003392
 protein coding gene Chr4:144460360-144495467 (-)
NZO/HlLtJ ENSMUSGG00225055562
 protein coding gene Chr4:159131573-159132716 (-)
NZO/HlLtJ ENSMUSG00225023097
 protein coding gene Chr4:159087728-159122634 (-)
PWK/PhJ ENSLUMG00010025816
 protein coding gene Chr4:143657804-143692642 (-)
SPRET/EiJ ENSMSPG00010023995
 protein coding gene Chr4:145594171-145656124 (-)
WSB/EiJ ENSIUOG00005006532
 protein coding gene Chr4:142671056-142704932 (-)



Homology
more
  • Human Ortholog
    KCNAB2, potassium voltage-gated channel subfamily A regulatory beta subunit 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNAB2, potassium voltage-gated channel subfamily A regulatory beta subunit 2
  • Synonyms
    AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2
  • Links
    NCBI Gene ID: 8514
    UniProt: Q13303

  • Chr Location
    1p36.31; chr1:5990927-6101193 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Kcnab2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show strain-specific changes in survival, body weight, thermoregulation and cold-swim induced tremors, impaired associative learning and memory, sporadic seizures and amygala hyperexcitability. Mice homozygous for a knock-in mutationshow no deficits in associative learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    78
  • cDNA Data
    53
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16498 NCBI Gene Model | MGI Sequence Detail 86791 C57BL/6J ±  kb
    transcript NM_001421224 RefSeq | MGI Sequence Detail 4066 ZRU/MplStud  
    polypeptide P62482 UniProt | EBI | MGI Sequence Detail 367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • Protein Ontology
      PR:000009252 voltage-gated potassium channel subunit beta-2
      (term hierarchy)
    • EC
      1.1.1.-
    • InterPro Domains
      IPR023210 NADP-dependent oxidoreductase domain
      IPR036812 NAD(P)-dependent oxidoreductase domain superfamily
      IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
      IPR005400 Potassium channel, voltage-dependent, beta subunit, KCNAB1
      IPR005401 Potassium channel, voltage-dependent, beta subunit, KCNAB2
      IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
    • GlyGen
      P62482 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 2
      cDNA 53
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11043, MGD-MRK-24441, MGD-MRK-38284
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 18
      Phenotypes 17
    • Earliest
      J:2307 Cohen JA, et al., Characterization of a novel mRNA expressed by neurons in mature brain. J Neurosci Res. 1992 Feb;31(2):273-84
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory