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Kcnab2 Gene Detail
Summary
  • Symbol
    Kcnab2
  • Name
    potassium voltage-gated channel, shaker-related subfamily, beta member 2
  • Synonyms
    F5, I2rf5, I2rf5, Kcnb3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109239
    NCBI Gene: 16498
  • Gene Overview
    MyGene.info: KCNAB2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152390740-152477549 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.08 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    889 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109239
protein coding gene Chr4:152390740-152477871 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029182
protein coding gene Chr4:156512457-156603260 (-)
A/J MGP_AJ_G0029147
protein coding gene Chr4:149951913-150039389 (-)
AKR/J MGP_AKRJ_G0029095
protein coding gene Chr4:154024219-154116091 (-)
BALB/cJ MGP_BALBcJ_G0029163
protein coding gene Chr4:150418522-150506378 (-)
C3H/HeJ MGP_C3HHeJ_G0028884
protein coding gene Chr4:154592129-154681179 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029612
protein coding gene Chr4:162129559-162222589 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026858
protein coding gene Chr4:142290736-142378603 (-)
CAST/EiJ MGP_CASTEiJ_G0028297
protein coding gene Chr4:151942034-152031649 (-)
CBA/J MGP_CBAJ_G0028846
protein coding gene Chr4:166959766-167054367 (-)
DBA/2J MGP_DBA2J_G0028995
protein coding gene Chr4:150003267-150089112 (-)
FVB/NJ MGP_FVBNJ_G0028959
protein coding gene Chr4:149166355-149259399 (-)
LP/J MGP_LPJ_G0029085
protein coding gene Chr4:156436474-156526713 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028986
protein coding gene Chr4:169962671-170055039 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029644
protein coding gene Chr4:154563445-154656817 (-)
PWK/PhJ MGP_PWKPhJ_G0028017
protein coding gene Chr4:146071136-146158717 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027851
protein coding gene Chr4:148854111-148942955 (-)
WSB/EiJ MGP_WSBEiJ_G0028377
protein coding gene Chr4:154750790-154846131 (-)



Homology
more
  • Human Ortholog
    KCNAB2, potassium voltage-gated channel subfamily A regulatory beta subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNAB2, potassium voltage-gated channel subfamily A regulatory beta subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2
  • Links
    NCBI Gene ID: 8514
    neXtProt AC: NX_Q13303
    UniProt: Q13303

  • Chr Location
    1p36.31; chr1:5992298-6101193 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56492
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KCNAB2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Kcnab2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show strain-specific changes in survival, body weight, thermoregulation and cold-swim induced tremors, impaired associative learning and memory, sporadic seizures and amygala hyperexcitability. Mice homozygous for a knock-in mutationshow no deficits in associative learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16498 NCBI Gene Model | MGI Sequence Detail 86810 C57BL/6J ±  kb
    transcript NM_001355173 RefSeq | MGI Sequence Detail 3664 C57BL/6  
    polypeptide P62482 UniProt | EBI | MGI Sequence Detail 367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • EC
    • InterPro Domains
      IPR023210 NADP-dependent oxidoreductase domain
      IPR036812 NADP-dependent oxidoreductase domain superfamily
      IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
      IPR005401 Potassium channel, voltage-dependent, beta subunit, KCNAB2
      IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 2
      cDNA 53
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11043, MGD-MRK-24441, MGD-MRK-38284
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 9
      Phenotypes 8
    • Earliest
      J:2307 Cohen JA, et al., Characterization of a novel mRNA expressed by neurons in mature brain. J Neurosci Res. 1992 Feb;31(2):273-84
    • Latest
      J:207858 Proepper C, et al., The Kvbeta2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD. Neuroscience. 2014 Mar 7;261:133-43

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory