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Kcnab2
Gene Detail
Symbol

Name
ID
Kcnab2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
MGI:109239
Synonyms
F5, I2rf5, I2rf5, Kcnb3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
83.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:152390742-152477871 bp, - strand
From VEGA annotation of GRCm38

  87130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56492  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Kcnab2

Human
homologs
Human Homolog KCNAB2, potassium voltage-gated channel, shaker-related subfamily, beta member 2
NCBI Gene ID 8514
neXtProt AC  NX_Q13303
Human Synonyms  AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2
Human Chr (Location)  1p36.3; chr1:5992298-6101193 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Kcnab2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show strain-specific changes in survival, body weight, thermoregulation and cold-swim induced tremors, impaired associative learning and memory, sporadic seizures and amygala hyperexcitability. Mice homozygous for a knock-in mutation show no deficits in associative learning.
 
Human Diseases Modeled Using Mouse Kcnab2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Kcnab2 interacts with 198 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process hematopoietic progenitor cell differentiation, ion transport, ...
Component cytoplasm, integral component of membrane, ...
Function protein binding, voltage-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (185)    Tissues (78)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 136
RT-PCR 49
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) Genomic(2) cDNA(53) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000033817 (Evidence)
Ensembl Gene ModelENSMUSG00000028931 (Evidence)
Entrez Gene16498 (Evidence)
UniGene388924
DFCITC1574642
DoTSDT.101123682, DT.101147940, DT.101397827, DT.110808421, DT.99862400, DT.97390311
NIA Mouse Gene IndexU025843
Consensus CDS ProjectCCDS19000.1, CCDS57316.1
International Mouse Knockout Project StatusKcnab2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033817 VEGA Gene Model | MGI Sequence Detail 87130 C57BL/6J ±  kb
transcript OTTMUST00000085182 VEGA | MGI Sequence Detail 1552 Not Applicable 
polypeptide OTTMUSP00000045986 VEGA | MGI Sequence Detail 382 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(26) UniProt(13)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(889 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001395 Aldo/keto reductase
InterPro IPR023210 NADP-dependent oxidoreductase domain
InterPro IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
InterPro IPR005401 Potassium channel, voltage-dependent, beta subunit, KCNAB2
InterPro IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
Protein Ontology PR:000009252 voltage-gated potassium channel subunit beta-2
References
(Earliest) J:2307 Cohen JA, et al., Characterization of a novel mRNA expressed by neurons in mature brain. J Neurosci Res. 1992 Feb;31(2):273-84
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(47)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11043, MGD-MRK-24441, MGD-MRK-38284

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory