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Kif21b Gene Detail
Summary
  • Symbol
    Kif21b
  • Name
    kinesin family member 21B
  • Synonyms
    2610511N21Rik, mKIAA0449, N-5 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:109234
    NCBI Gene: 16565
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:136131389-136177998 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46610 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 59.61 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KIF21B, kinesin family member 21B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KIF21B, kinesin family member 21B
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23046
    neXtProt AC: NX_O75037
    UniProt: O75037

  • Chr Location
    1q32.1; chr1:200969386-201023700 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO reduces dendrite branching and spine density as a result of reduced microtubule growth, resulting in impaired spatial learning and cued conditioning behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026867 VEGA Gene Model | MGI Sequence Detail 46610 C57BL/6J ±  kb
    transcript OTTMUST00000066456 VEGA | MGI Sequence Detail 9254 Not Applicable  
    polypeptide OTTMUSP00000033305 VEGA | MGI Sequence Detail 1639 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      408 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • InterPro Domains
      IPR027640 Kinesin-like protein
      IPR001752 Kinesin motor domain
      IPR019821 Kinesin motor domain, conserved site
      IPR036961 Kinesin motor domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR017986 WD40-repeat-containing domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 184
      cDNA 183
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38278, MGI:2443746
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:249035 Kannan M, et al., WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory