Kif21b MGI Mouse Gene Detail - MGI:109234 - kinesin family member 21B

Symbol

Kif21b
Name

kinesin family member 21B
Synonyms

2610511N21Rik, mKIAA0449, N-5 kinesin

Feature Type

protein coding gene
IDs

MGI:109234
NCBI Gene: 16565
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:136059127-136105736 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.61 cM
Mapping Data

3 experiments

SNPs within 2kb

408 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109234	protein coding gene	Chr1:136059127-136105739 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016536	protein coding gene	Chr1:139932873-139982611 (+)
A/J	MGP_AJ_G0016519	protein coding gene	Chr1:134638732-134686147 (+)
AKR/J	MGP_AKRJ_G0016484	protein coding gene	Chr1:138642775-138689342 (+)
BALB/cJ	MGP_BALBcJ_G0016479	protein coding gene	Chr1:134967861-135015164 (+)
C3H/HeJ	MGP_C3HHeJ_G0016305	protein coding gene	Chr1:138737282-138783823 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016940	protein coding gene	Chr1:144960556-145012490 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014651	protein coding gene	Chr1:127741538-127788559 (+)
CAST/EiJ	MGP_CASTEiJ_G0015885	protein coding gene	Chr1:137831297-137878518 (+)
CBA/J	MGP_CBAJ_G0016278	protein coding gene	Chr1:149985679-150034331 (+)
DBA/2J	MGP_DBA2J_G0016384	protein coding gene	Chr1:133633324-133679607 (+)
FVB/NJ	MGP_FVBNJ_G0016383	protein coding gene	Chr1:132279440-132325849 (+)
LP/J	MGP_LPJ_G0016455	protein coding gene	Chr1:141161154-141211554 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016408	protein coding gene	Chr1:155621550-155669582 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016976	protein coding gene	Chr1:138407178-138454699 (+)
PWK/PhJ	MGP_PWKPhJ_G0015671	protein coding gene	Chr1:132677584-132725546 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015458	protein coding gene	Chr1:137394286-137441141 (+)
WSB/EiJ	MGP_WSBEiJ_G0015948	protein coding gene	Chr1:138451285-138499062 (+)

Human Ortholog

KIF21B, kinesin family member 21B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF21B, kinesin family member 21B
Links

HGNC:29442

NCBI Gene ID: 23046

neXtProt AC: NX_O75037

UniProt: O75037
Chr Location

1q32.1; chr1:200969390-201023714 (-) GRCh38

MGI Vertebrate Homology

Kif21b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF21B
Gene Tree

Kif21b

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Targeted

7
Genomic Mutations

3 involving Kif21b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

88 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous KO reduces dendrite branching and spine density as a result of reduced microtubule growth, resulting in impaired spatial learning and cued conditioning behavior.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

848
Tissues

30
cDNA Data

186
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif21b

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All Sequences

56
RefSeq

3
UniProt

9
CCDS

CCDS15324.1

Ensembl

ENSMUSG00000041642 (Evidence)
NCBI Gene

16565

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041642	Ensembl Gene Model \| MGI Sequence Detail	46610	C57BL/6J	± kb
transcript	ENSMUST00000130864	Ensembl \| MGI Sequence Detail	9254	Not Applicable
polypeptide	ENSMUSP00000114297	Ensembl \| MGI Sequence Detail	1639	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000009300 kinesin-like protein KIF21B

(term hierarchy)
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 188

cDNA 186

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-38278, MGI:2443746

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:338397 Gromova KV, et al., The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling. Cell Rep. 2023 Jul 6;42(7):112743

TSS for Kif21b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9041	Chr1:136059101-136059119 (+)	-17 bp
Tssr9042	Chr1:136059120-136059142 (+)	4 bp
Tssr9043	Chr1:136059149-136059179 (+)	37 bp
Tssr9044	Chr1:136059181-136059232 (+)	80 bp
Tssr9045	Chr1:136060774-136060777 (+)	1,649 bp
Tssr9046	Chr1:136072966-136072973 (+)	13,843 bp
Tssr9047	Chr1:136074287-136074289 (+)	15,161 bp
Tssr9048	Chr1:136074390-136074403 (+)	15,270 bp
Tssr9049	Chr1:136090679-136090690 (+)	31,558 bp
Tssr9050	Chr1:136100441-136100448 (+)	41,318 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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