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Npas2
Gene Detail
Symbol

Name
ID
Npas2
neuronal PAS domain protein 2
MGI:109232
Synonyms
bHLHe9, MOP4
Feature Type
protein coding gene
Genetic Map
Chromosome 1
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:39193731-39363236 bp, + strand
From VEGA annotation of GRCm38

  169506 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1887  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: NPAS2
Gene Tree: Npas2

Human
homologs
NPAS2, neuronal PAS domain protein 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4862
neXtProt AC: NX_Q99743

Human Synonyms: bHLHe9, MOP4, PASD4

Human Chr (Location): 2q11.2; chr2:100820151-100996827 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Targeted mutation of this gene results in deficits in complex emotional long-term memory tasks
 
Interactions
Npas2 interacts with 231 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cellular response to DNA damage stimulus, circadian regulation of gene expression, ...
Component cytoplasm, nucleus, ...
Function DNA binding, Hsp90 protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (207)    Tissues (204)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 199
RT-PCR 8
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NPAS2 ZFIN npas2    NEW 
Molecular
reagents
All nucleic(17) cDNA(14) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000036938 (Evidence)
Ensembl Gene Model ENSMUSG00000026077 (Evidence)
Entrez Gene 18143 (Evidence)
UniGene 2380
DFCI TC1589507, TC1617572
DoTS DT.91333657, DT.99853557
NIA Mouse Gene Index U000188
Consensus CDS Project CCDS48244.1
International Mouse Phenotyping Consortium Status Npas2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036938 VEGA Gene Model | MGI Sequence Detail 169506 C57BL/6J ±  kb
transcript OTTMUST00000094905 VEGA | MGI Sequence Detail 4236 Not Applicable 
polypeptide OTTMUSP00000052908 VEGA | MGI Sequence Detail 816 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(1348 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001067 Nuclear translocator
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
Protein Ontology PR:000011350 neuronal PAS domain-containing protein 2
References
(Earliest) J:37770 Zhou YD, et al., Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):713-8
(Latest) J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
All references(56)
Other
accession IDs
MGD-MRK-38276

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory