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Npas2
Gene Detail
 Symbol
Name
ID
Npas2
neuronal PAS domain protein 2
MGI:109232
Synonyms bHLHe9, MOP4
Feature Type protein coding gene
Genetic Map
Chromosome 1
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:39193731-39363234 bp, + strand
From VEGA annotation of GRCm38

  169504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1887  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Npas2

Human
homologs
Human Homolog NPAS2, neuronal PAS domain protein 2
NCBI Gene ID 4862
neXtProt AC  NX_Q99743
Human Synonyms  bHLHe9, MOP4, PASD4
Human Chr (Location)  2q11.2; chr2:100820151-100996827 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Targeted mutation of this gene results in deficits in complex emotional long-term memory tasks
 
Interactions
Npas2 interacts with 232 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cellular response to DNA damage stimulus, circadian regulation of gene expression, ...
Component cytoplasm, nucleus, ...
Function DNA binding, Hsp90 protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (207)    Tissues (201)    Images (13)
Theiler Stages: 2, 3, 4, 5, 16, 17, 19, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 199
RT-PCR 8
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(14) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036938 (Evidence)
Ensembl Gene ModelENSMUSG00000026077 (Evidence)
Entrez Gene18143 (Evidence)
UniGene2380
DFCITC1589507, TC1617572
DoTSDT.91333657, DT.99853557
NIA Mouse Gene IndexU000188
Consensus CDS ProjectCCDS48244.1
International Mouse Knockout Project StatusNpas2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036938 VEGA Gene Model | MGI Sequence Detail 169504 C57BL/6J ±  kb
transcript OTTMUST00000094905 VEGA | MGI Sequence Detail 4234 Not Applicable 
polypeptide OTTMUSP00000052908 VEGA | MGI Sequence Detail 816 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(1348 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001067 Nuclear translocator
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
Protein Ontology PR:000011350 neuronal PAS domain-containing protein 2
References (Earliest) J:37770 Zhou YD, et al., Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):713-8
(Latest) J:209471 Yoshii K, et al., Effects of NAD(P)H and its derivatives on the DNA-binding activity of NPAS2, a mammalian circadian transcription factor. Biochem Biophys Res Commun. 2013 Aug 2;437(3):386-91
All references(56)
Other
accession IDs
MGD-MRK-38276

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory