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Npas2 Gene Detail
Summary
  • Symbol
    Npas2
  • Name
    neuronal PAS domain protein 2
  • Synonyms
    bHLHe9, MOP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109232
    NCBI Gene: 18143
  • Gene Overview
    MyGene.info: NPAS2
Location & Maps
more
  • Sequence Map
    Chr1:39193731-39363236 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      169506 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NPAS2, neuronal PAS domain protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NPAS2, neuronal PAS domain protein 2
    Orthology source: HomoloGene
  • Synonyms
    bHLHe9, MOP4, PASD4
  • Links
    NCBI Gene ID: 4862
    neXtProt AC: NX_Q99743

  • Chr Location
    2q11.2; chr2:100820151-100996827 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Npas2
Targeted mutation of this gene results in deficits in complex emotional long-term memory tasks
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036938 VEGA Gene Model | MGI Sequence Detail 169506 C57BL/6J ±  kb
transcript OTTMUST00000094905 VEGA | MGI Sequence Detail 4236 Not Applicable  
polypeptide OTTMUSP00000052908 VEGA | MGI Sequence Detail 816 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1344 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 14
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38276
References
more
  • Summaries
    All 53
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:37770 Zhou YD, et al., Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):713-8
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory