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Efnb3
Gene Detail
Symbol

Name
ID
Efnb3
ephrin B3
MGI:109196
Synonyms
EFL-6, ELF-3, Elk-L3, Epl8, LERK-8, NLERK-2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:69554092-69560205 bp, - strand
From VEGA annotation of GRCm38

  6114 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1076  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: EFNB3
Protein SuperFamily: Ephrin-B
Gene Tree: Efnb3

Human
homologs
EFNB3, ephrin-B3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1949
neXtProt AC: NX_Q15768

Human Synonyms: EFL6, EPLG8, LERK8

Human Chr (Location): 17p13.1; chr17:7705202-7711375 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null mutations exhibit a hopping gait due to corticospinal tract defects. Mutations that remove only the cytoplasmic domain of the protein do not result in the gait or CNS phenotypes.
 
Interactions
Efnb3 interacts with 254 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process adult walking behavior, axon choice point recognition, ...
Component integral component of membrane, membrane, ...
Function ephrin receptor binding
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (350)    Tissues (182)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 326
In situ reporter (knock in) 1
RT-PCR 12
cDNA source data(65)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase efnb3 ; ZFIN efnb3b    NEW 
Molecular
reagents
All nucleic(74) Genomic(1) cDNA(70) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005987 (Evidence)
Ensembl Gene Model ENSMUSG00000003934 (Evidence)
Entrez Gene 13643 (Evidence)
UniGene 249637
DFCI TC1577018
DoTS DT.526740, DT.110517678
NIA Mouse Gene Index U032965
PDB 3D12
Consensus CDS Project CCDS24896.1
International Mouse Phenotyping Consortium Status Efnb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005987 VEGA Gene Model | MGI Sequence Detail 6114 C57BL/6J ±  kb
transcript OTTMUST00000013398 VEGA | MGI Sequence Detail 3183 Not Applicable 
polypeptide OTTMUSP00000006203 VEGA | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR001799 Ephrin
InterPro IPR019765 Ephrin, conserved site
Protein Ontology PR:000006923 ephrin-B3
References
(Earliest) J:35772 Gale NW, et al., Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. Oncogene. 1996 Sep 19;13(6):1343-52
(Latest) J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57
All references(108)
Other
accession IDs
MGD-MRK-38240

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory