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Efnb3 Gene Detail
Summary
  • Symbol
    Efnb3
  • Name
    ephrin B3
  • Synonyms
    EFL-6, ELF-3, Elk-L3, Epl8, LERK-8, NLERK-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109196
    NCBI Gene: 13643
  • Gene Overview
    MyGene.info: EFNB3
Location & Maps
more
  • Sequence Map
    Chr11:69554092-69560205 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6114 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.80 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EFNB3, ephrin B3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EFNB3, ephrin B3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EFL6, EPLG8, LERK8
  • Links
    NCBI Gene ID: 1949
    neXtProt AC: NX_Q15768

  • Chr Location
    17p13.1; chr17:7705202-7711375 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 10 alleles in 8 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Spontaneous
    1
  • Targeted
    10
  • Genomic Mutations
    1 involving Efnb3
  • Incidental Mutations
Mice homozygous for null mutations exhibit a hopping gait due to corticospinal tract defects, mutations that remove only the cytoplasmic domain of the protein do not result in the gait or CNS phenotypes, and a G244E mutation causes ataxia
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005987 VEGA Gene Model | MGI Sequence Detail 6114 C57BL/6J ±  kb
transcript OTTMUST00000013398 VEGA | MGI Sequence Detail 3183 Not Applicable  
polypeptide OTTMUSP00000006203 VEGA | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    79 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 75
    Genomic 1
    cDNA 70
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38240
References
more
  • Summaries
    All 108
    Developmental Gene Expression 59
    Gene Ontology 8
    Phenotypes 32
  • Earliest
    J:35772 Gale NW, et al., Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. Oncogene. 1996 Sep 19;13(6):1343-52
  • Latest
    J:226023 Murillo B, et al., Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain. J Neurosci. 2015 Aug 12;35(32):11266-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory