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Ywhah Gene Detail
Summary
  • Symbol
    Ywhah
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
  • Synonyms
    14-3-3 eta
  • Feature Type
    protein coding gene
  • IDs
    MGI:109194
    NCBI Gene: 22629
  • Gene Overview
    MyGene.info: YWHAH
Location & Maps
more
  • Sequence Map
    Chr5:33018816-33027966 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9151 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.42 cM, cytoband B1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    YWHA1
  • Links
    NCBI Gene ID: 7533
    neXtProt AC: NX_Q04917

  • Chr Location
    22q12.3; chr22:31944493-31957603 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
  • All Mutations and Alleles
    35
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    28
  • Radiation induced
    3
  • Spontaneous
    1
  • Genomic Mutations
    7 involving Ywhah
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016346 VEGA Gene Model | MGI Sequence Detail 9151 C57BL/6J ±  kb
transcript OTTMUST00000039297 VEGA | MGI Sequence Detail 1764 Not Applicable  
polypeptide OTTMUSP00000017560 VEGA | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    18 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 254
    cDNA 252
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38238
References
more
  • Summaries
    All 46
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 8
    Phenotypes 27
  • Earliest
    J:25272 McConnell JE, et al., The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation. Dev Biol. 1995 May;169(1):218-28
  • Latest
    J:196438 De S, et al., Evidence for the requirement of 14-3-3eta (YWHAH) in meiotic spindle assembly during mouse oocyte maturation. BMC Dev Biol. 2013;13:10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory