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Ywhah
Gene Detail
Symbol

Name
ID
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
MGI:109194
Synonyms
14-3-3 eta
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.42 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:33018816-33027966 bp, + strand
From VEGA annotation of GRCm38

  9151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37767  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: YWHAH
Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhah

Human
homologs
YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7533
neXtProt AC: NX_Q04917

Human Synonyms: YWHA1

Human Chr (Location): 22q12.3; chr22:31944493-31957603 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Chemically induced (ENU)(1) Gene trapped(28) Radiation induced(3)
Genomic Mutations involving Ywhah (4)
Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Ywhah interacts with 190 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cytoskeleton organization, glucocorticoid catabolic process, ...
Component cytoplasm, extracellular exosome, ...
Function actin binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (216)    Tissues (170)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 170
RT-PCR 46
cDNA source data(252)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA YWHAH ; Xenbase ywhah ; ZFIN ywhah    NEW 
Molecular
reagents
All nucleic(254) cDNA(252) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016346 (Evidence)
Ensembl Gene Model ENSMUSG00000018965 (Evidence)
Entrez Gene 22629 (Evidence)
UniGene 332314
DFCI TC1573295, TC1589794
DoTS DT.101397586, DT.110686145, DT.536824, DT.55221074, DT.91430131
Consensus CDS Project CCDS19198.1
International Mouse Phenotyping Consortium Status Ywhah
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016346 VEGA Gene Model | MGI Sequence Detail 9151 C57BL/6J ±  kb
transcript OTTMUST00000039297 VEGA | MGI Sequence Detail 1764 Not Applicable 
polypeptide OTTMUSP00000017560 VEGA | MGI Sequence Detail 246 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023410 14-3-3 domain
InterPro IPR000308 14-3-3 protein
InterPro IPR023409 14-3-3 protein, conserved site
Protein Ontology PR:000017551 14-3-3 protein eta
References
(Earliest) J:25272 McConnell JE, et al., The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation. Dev Biol. 1995 May;169(1):218-28
(Latest) J:196438 De S, et al., Evidence for the requirement of 14-3-3eta (YWHAH) in meiotic spindle assembly during mouse oocyte maturation. BMC Dev Biol. 2013;13:10
All references(48)
Other
accession IDs
MGD-MRK-38238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory