Fgf14
Gene Detail

Symbol Name ID

Fgf14 fibroblast growth factor 14 MGI:109189

Synonyms

Fhf4

Feature Type

protein coding gene

Genetic Map

Chromosome 14

66.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:123977907-124677127 bp, - strand From VEGA annotation of GRCm38   699221 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3037  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Fgf14

Human homologs

Human Homolog		FGF14, fibroblast growth factor 14
NCBI Gene ID		2259
neXtProt AC		NX_Q92915
Human Synonyms		FGF-14, FHF4, FHF-4, SCA27
Human Chr (Location)		13q34; chr13:102373205-103054124 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FGF14

Alleles and phenotypes

All alleles(12) : Targeted(1) Gene trapped(11)
 

Mice homozygous for disruptions in this gene display impaired balance and grip strength.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	adult locomotory behavior, JNK cascade, ...
Component	nucleus
Function	growth factor activity, heparin binding

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (309)    Tissues (119)    Images (34)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	294
RT-PCR	15

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(17) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021491 (Evidence)
Ensembl Gene Model	ENSMUSG00000025551 (Evidence)
Entrez Gene	14169 (Evidence)
UniGene	439768
DFCI	TC1583420, TC1588886
DoTS	DT.110746918, DT.87049178, DT.97403338
NIA Mouse Gene Index	U035966
Consensus CDS Project	CCDS27355.1, CCDS27356.1
International Mouse Knockout Project Status	Fgf14

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021491	VEGA Gene Model | MGI Sequence Detail	699221	C57BL/6J
transcript	OTTMUST00000050938	VEGA | MGI Sequence Detail	3608	Not Applicable
polypeptide	OTTMUSP00000023900	VEGA | MGI Sequence Detail	252	Not Applicable

All sequences(34) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(1467 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008996	Cytokine, IL-1-like
InterPro	IPR002209	Heparin-binding growth factor/Fibroblast growth factor
InterPro	IPR002348	Interleukin 1/heparin-binding growth factor
Protein Ontology	PR:000007484	fibroblast growth factor 14

References

(Earliest) J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
(Latest) J:186161 Hu B, et al., Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
All references(47)

Other accession IDs

MGD-MRK-38233