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Fgf14
Gene Detail
 Symbol
Name
ID
Fgf14
fibroblast growth factor 14
MGI:109189
Synonyms Fhf4
Feature Type protein coding gene
Genetic Map
Chromosome 14
66.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:123977907-124677127 bp, - strand
From VEGA annotation of GRCm38

  699221 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3037  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Fgf14

Human
homologs
Human Homolog FGF14, fibroblast growth factor 14
NCBI Gene ID 2259
neXtProt AC  NX_Q92915
Human Synonyms  FGF-14, FHF4, FHF-4, SCA27
Human Chr (Location)  13q34; chr13:101720855-102401774 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FGF14
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(11) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display impaired balance and grip strength.
 
Interactions
Fgf14 interacts with 363 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process adult locomotory behavior, JNK cascade, ...
Component extracellular region, intracellular, ...
Function growth factor activity, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (352)    Tissues (147)    Images (52)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 326
RT-PCR 15
RNase protection 11
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(14) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021491 (Evidence)
Ensembl Gene ModelENSMUSG00000025551 (Evidence)
Entrez Gene14169 (Evidence)
DFCITC1583420, TC1588886
DoTSDT.110746918, DT.87049178, DT.97403338
NIA Mouse Gene IndexU035966
Consensus CDS ProjectCCDS27355.1, CCDS27356.1
International Mouse Knockout Project StatusFgf14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021491 VEGA Gene Model | MGI Sequence Detail 699221 C57BL/6J ±  kb
transcript OTTMUST00000050938 VEGA | MGI Sequence Detail 3608 Not Applicable 
polypeptide OTTMUSP00000023900 VEGA | MGI Sequence Detail 252 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(2119 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2121)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007484 fibroblast growth factor 14
References (Earliest) J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
(Latest) J:200997 Yan H, et al., FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. Cell Rep. 2013 Jul 11;4(1):66-75
All references(48)
Other
accession IDs
MGD-MRK-38233

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory