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Fgf14 Gene Detail
Summary
  • Symbol
    Fgf14
  • Name
    fibroblast growth factor 14
  • Synonyms
    Fhf4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109189
    NCBI Gene: 14169
  • Gene Overview
    MyGene.info: FGF14
Location & Maps
more
  • Sequence Map
    Chr14:123977907-124677127 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      699221 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FGF14, fibroblast growth factor 14
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FGF14, fibroblast growth factor 14
    Orthology source: HomoloGene
  • Synonyms
    FGF-14, FHF4, FHF-4, SCA27
  • Links
    NCBI Gene ID: 2259
    neXtProt AC: NX_Q92915

  • Chr Location
    13q34; chr13:101719784-102401774 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Fgf14 mouse models; 1 with human FGF14 associations

Human Disease Mouse Models
       Spinocerebellar Ataxia 27; SCA27   OMIM: 609307 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display impaired balance and grip strength.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021491 VEGA Gene Model | MGI Sequence Detail 699221 C57BL/6J ±  kb
transcript OTTMUST00000050938 VEGA | MGI Sequence Detail 3608 Not Applicable  
polypeptide OTTMUSP00000023900 VEGA | MGI Sequence Detail 252 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2093 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 18
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-38233
References
more
  • Summaries
    All 48
    Developmental Gene Expression 18
    Diseases 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
  • Latest
    J:221659 Bosch MK, et al., Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance. J Neurosci. 2015 Apr 29;35(17):6752-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory