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Fgf14
Gene Detail
Symbol

Name
ID
Fgf14
fibroblast growth factor 14
MGI:109189
Synonyms
Fhf4
Feature Type
protein coding gene
Genetic Map
Chromosome 14
66.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:123977907-124677127 bp, - strand
From VEGA annotation of GRCm38

  699221 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3037  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGF14
Gene Tree: Fgf14

Human
homologs
FGF14, fibroblast growth factor 14
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2259
neXtProt AC: NX_Q92915

Human Synonyms: FGF-14, FHF4, FHF-4, SCA27

Human Chr (Location): 13q34; chr13:101719784-102401774 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FGF14

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(11) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display impaired balance and grip strength.
 
Human Diseases Modeled in Mice Using Fgf14 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Fgf14 interacts with 363 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process adult locomotory behavior, JNK cascade, ...
Component cytosol, extracellular region, ...
Function growth factor activity, heparin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (352)    Tissues (148)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 326
RT-PCR 15
RNase protection 11
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FGF14 ; Xenbase fgf14    NEW 
Molecular
reagents
All nucleic(18) cDNA(14) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021491 (Evidence)
Ensembl Gene Model ENSMUSG00000025551 (Evidence)
Entrez Gene 14169 (Evidence)
DFCI TC1583420, TC1588886
DoTS DT.110746918, DT.87049178, DT.97403338
NIA Mouse Gene Index U035966
Consensus CDS Project CCDS27355.1, CCDS27356.1
International Mouse Phenotyping Consortium Status Fgf14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021491 VEGA Gene Model | MGI Sequence Detail 699221 C57BL/6J ±  kb
transcript OTTMUST00000050938 VEGA | MGI Sequence Detail 3608 Not Applicable 
polypeptide OTTMUSP00000023900 VEGA | MGI Sequence Detail 252 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(2119 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2121)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR028284 Fibroblast growth factor 14
InterPro IPR002209 Fibroblast growth factor family
InterPro IPR028142 IL-1 family/FGF family
Protein Ontology PR:000007484 fibroblast growth factor 14
References
(Earliest) J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
(Latest) J:221659 Bosch MK, et al., Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance. J Neurosci. 2015 Apr 29;35(17):6752-69
All references(51)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-38233

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory