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Ncf4
Gene Detail
Symbol

Name
ID
Ncf4
neutrophil cytosolic factor 4
MGI:109186
Synonyms
p40phox
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:78244801-78262580 bp, + strand
From VEGA annotation of GRCm38

  17780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:525  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ncf4

Human
homologs
Human Homolog NCF4, neutrophil cytosolic factor 4, 40kDa
NCBI Gene ID 4689
neXtProt AC  NX_Q15080
Human Synonyms  NCF, P40PHOX, SH3PXD4
Human Chr (Location)  22q13.1; chr22:36860988-36878017 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NCF4
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Ncf4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are viable but show impaired NADPH oxidase responses of neutrophils to a variety of stimuli and defective killing of S. aureus in vitro and in vivo. Homozygotes for a knock-in allele that prevents PtdIns3P binding to the PX domain fail in development prior to E10.
 
Interactions
Ncf4 interacts with 29 markers (Mir19b-2, Mir22, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process positive regulation of catalytic activity
Component cytoplasm, cytosol, ...
Function lipid binding, phosphatidylinositol-3-phosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(34)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028142 (Evidence)
Ensembl Gene ModelENSMUSG00000071715 (Evidence)
Entrez Gene17972 (Evidence)
UniGene2068
DFCITC1578235
DoTSDT.101351240, DT.532747
NIA Mouse Gene IndexU016402
Consensus CDS ProjectCCDS27610.1
International Mouse Knockout Project StatusNcf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028142 VEGA Gene Model | MGI Sequence Detail 17780 C57BL/6J ±  kb
transcript OTTMUST00000069709 VEGA | MGI Sequence Detail 1464 Not Applicable 
polypeptide OTTMUSP00000035448 VEGA | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(193 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000919 Neutrophil cytosol factor P40
InterPro IPR000270 Phox/Bem1p
InterPro IPR001683 Phox homologous domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000011032 neutrophil cytosol factor 4
References
(Earliest) J:38735 Zhan S, et al., Cloning and chromosomal localization of ncf4, the mouse homologue of p40-phox. Immunogenetics. 1997;45(3):217-9
(Latest) J:207411 de Luca A, et al., IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3526-31
All references(43)
Other
accession IDs
MGD-MRK-38230, MGI:2146016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory