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Ncf4
Gene Detail
Symbol

Name
ID
Ncf4
neutrophil cytosolic factor 4
MGI:109186
Synonyms
p40phox
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:78244801-78262580 bp, + strand
From VEGA annotation of GRCm38

  17780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:525  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NCF4
Gene Tree: Ncf4

Human
homologs
NCF4, neutrophil cytosolic factor 4, 40kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4689
neXtProt AC: NX_Q15080

Human Synonyms: NCF, P40PHOX, SH3PXD4

Human Chr (Location): 22q13.1; chr22:36860988-36878017 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NCF4

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Ncf4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are viable but show impaired NADPH oxidase responses of neutrophils to a variety of stimuli and defective killing of S. aureus in vitro and in vivo. Homozygotes for a knock-in allele that prevents PtdIns3P binding to the PX domain fail in development prior to E10.
 
Phenotype Images(2)
Interactions
Ncf4 interacts with 29 markers (Mir19b-2, Mir22, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process positive regulation of catalytic activity
Component cytoplasm, cytosol, ...
Function lipid binding, phosphatidylinositol-3-phosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ncf4 ; ZFIN ncf4    NEW 
Molecular
reagents
All nucleic(34) cDNA(34)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000028142 (Evidence)
Ensembl Gene Model ENSMUSG00000071715 (Evidence)
Entrez Gene 17972 (Evidence)
UniGene 2068
DFCI TC1578235
DoTS DT.101351240, DT.532747
NIA Mouse Gene Index U016402
Consensus CDS Project CCDS27610.1
International Mouse Phenotyping Consortium Status Ncf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028142 VEGA Gene Model | MGI Sequence Detail 17780 C57BL/6J ±  kb
transcript OTTMUST00000069709 VEGA | MGI Sequence Detail 1464 Not Applicable 
polypeptide OTTMUSP00000035448 VEGA | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(193 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000919 Neutrophil cytosol factor P40
InterPro IPR000270 Phox/Bem1p
InterPro IPR001683 Phox homologous domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000011032 neutrophil cytosol factor 4
References
(Earliest) J:38735 Zhan S, et al., Cloning and chromosomal localization of ncf4, the mouse homologue of p40-phox. Immunogenetics. 1997;45(3):217-9
(Latest) J:207411 de Luca A, et al., IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3526-31
All references(43)
Other
accession IDs
MGD-MRK-38230, MGI:2146016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory