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Ncf4 Gene Detail
Summary
  • Symbol
    Ncf4
  • Name
    neutrophil cytosolic factor 4
  • Synonyms
    p40phox
  • Feature Type
    protein coding gene
  • IDs
    MGI:109186
    NCBI Gene: 17972
  • Gene Overview
    MyGene.info: NCF4
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78244801-78262580 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.10 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109186
protein coding gene Chr15:78244164-78262582 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022038
protein coding gene Chr15:78410217-78427489 (+)
A/J MGP_AJ_G0021998
protein coding gene Chr15:75677436-75696374 (+)
AKR/J MGP_AKRJ_G0021975
protein coding gene Chr15:77768737-77786028 (+)
BALB/cJ MGP_BALBcJ_G0022006
protein coding gene Chr15:75693400-75713418 (+)
C3H/HeJ MGP_C3HHeJ_G0021777
protein coding gene Chr15:77831931-77849179 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022448
protein coding gene Chr15:81483381-81500587 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019977
protein coding gene Chr15:72240594-72257926 (+)
CAST/EiJ MGP_CASTEiJ_G0021297
protein coding gene Chr15:78448279-78465478 (+)
CBA/J MGP_CBAJ_G0021742
protein coding gene Chr15:83995882-84013154 (+)
DBA/2J MGP_DBA2J_G0021870
protein coding gene Chr15:75174109-75191407 (+)
FVB/NJ MGP_FVBNJ_G0021849
protein coding gene Chr15:74171309-74188485 (+)
LP/J MGP_LPJ_G0021939
protein coding gene Chr15:78577881-78596153 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021869
protein coding gene Chr15:89192310-89211228 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022462
protein coding gene Chr15:77861464-77878645 (+)
PWK/PhJ MGP_PWKPhJ_G0021039
protein coding gene Chr15:75161015-75180161 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020875
protein coding gene Chr15:77620787-77638254 (+)
WSB/EiJ MGP_WSBEiJ_G0021350
protein coding gene Chr15:78178916-78198072 (+)



Homology
more
  • Human Ortholog
    NCF4, neutrophil cytosolic factor 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NCF4, neutrophil cytosolic factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGD3, NCF, P40PHOX, SH3PXD4
  • Links
    NCBI Gene ID: 4689
    neXtProt AC: NX_Q15080
    UniProt: Q15080

  • Chr Location
    22q12.3; chr22:36860988-36878017 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 525
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NCF4
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable but show impaired NADPH oxidase responses of neutrophils to a variety of stimuli and defective killing of S. aureus in vitro and in vivo. Homozygotes for a knock-in allele that prevents PtdIns3P binding to thePX domain fail in development prior to E10.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071715 Ensembl Gene Model | MGI Sequence Detail 17780 C57BL/6J ±  kb
    transcript ENSMUST00000096357 Ensembl | MGI Sequence Detail 1464 Not Applicable  
    polypeptide ENSMUSP00000094084 Ensembl | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 35

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38230, MGI:2146016
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 36
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:243517 Bagaitkar J, et al., PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo. J Leukoc Biol. 2017 Feb;101(2):449-457

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory