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Fgf12 Gene Detail
Summary
  • Symbol
    Fgf12
  • Name
    fibroblast growth factor 12
  • Synonyms
    Fhf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109183
    NCBI Gene: 14167
  • Gene Overview
    MyGene.info: FGF12
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:28160098-28753068 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 19.38 cM, cytoband B1-B3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4633 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109183
protein coding gene Chr16:28157783-28753243 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022701
protein coding gene Chr16:25962268-26250213 (-)
A/J MGP_AJ_G0022664
protein coding gene Chr16:24760805-25044910 (-)
AKR/J MGP_AKRJ_G0022638
protein coding gene Chr16:25728364-26000495 (-)
BALB/cJ MGP_BALBcJ_G0022668
protein coding gene Chr16:24940437-25224272 (-)
C3H/HeJ MGP_C3HHeJ_G0022433
protein coding gene Chr16:25821645-26096121 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023117
protein coding gene Chr16:26516727-26822337 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020635
protein coding gene Chr16:25263091-25528275 (-)
CAST/EiJ MGP_CASTEiJ_G0021961
protein coding gene Chr16:25886124-26173429 (-)
CBA/J MGP_CBAJ_G0022403
protein coding gene Chr16:27637124-27943561 (-)
DBA/2J MGP_DBA2J_G0022536
protein coding gene Chr16:24658545-24938744 (-)
FVB/NJ MGP_FVBNJ_G0022511
protein coding gene Chr16:24640869-24922010 (-)
LP/J MGP_LPJ_G0022603
protein coding gene Chr16:25753542-26040657 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022530
protein coding gene Chr16:27265123-27566065 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023129
protein coding gene Chr16:25670693-25956274 (-)
PWK/PhJ MGP_PWKPhJ_G0021700
protein coding gene Chr16:24945577-25218978 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021531
protein coding gene Chr16:25405252-25691107 (-)
WSB/EiJ MGP_WSBEiJ_G0022005
protein coding gene Chr16:25625021-25896573 (-)



Homology
more
  • Human Ortholog
    FGF12, fibroblast growth factor 12
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FGF12, fibroblast growth factor 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIEE47, FGF12B, FHF1
  • Links
    NCBI Gene ID: 2257
    neXtProt AC: NX_P61328
    UniProt: P61328

  • Chr Location
    3q28-q29; chr3:192139393-192727599 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    6 phenotype references
Mice homozygous for a knock-out allele are viable, fertile, and do not exhibit any significant behavioral or neurological phenotypes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022523 Ensembl Gene Model | MGI Sequence Detail 592971 C57BL/6J ±  kb
transcript ENSMUST00000100024 Ensembl | MGI Sequence Detail 4137 Not Applicable  
polypeptide ENSMUSP00000097601 Ensembl | MGI Sequence Detail 243 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    Genomic 1
    cDNA 35
    Primer pair 7
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38227, MGI:2146595
References
more
  • Summaries
    All 60
    Developmental Gene Expression 25
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
  • Latest
    J:239525 Peskett E, et al., Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme. Biol Open. 2017 Feb 15;6(2):223-231

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory