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Cpt2 Gene Detail
Summary
  • Symbol
    Cpt2
  • Name
    carnitine palmitoyltransferase 2
  • Synonyms
    CPTII, CPT II
  • Feature Type
    protein coding gene
  • IDs
    MGI:109176
    NCBI Gene: 12896
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:107903982-107923589 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 50.18 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109176
protein coding gene Chr4:107903981-107923610 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028545
protein coding gene Chr4:108608381-108628079 (-)
A/J MGP_AJ_G0028508
protein coding gene Chr4:104707848-104727469 (-)
AKR/J MGP_AKRJ_G0028455
protein coding gene Chr4:107281752-107301241 (-)
BALB/cJ MGP_BALBcJ_G0028527
protein coding gene Chr4:104908141-104928401 (-)
C3H/HeJ MGP_C3HHeJ_G0028241
protein coding gene Chr4:108023975-108044000 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028967
protein coding gene Chr4:112500516-112524972 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026258
protein coding gene Chr4:100016006-100033921 (-)
CAST/EiJ MGP_CASTEiJ_G0027677
protein coding gene Chr4:105858196-105878976 (-)
CBA/J MGP_CBAJ_G0028210
protein coding gene Chr4:116141503-116168831 (-)
DBA/2J MGP_DBA2J_G0028358
protein coding gene Chr4:104330606-104350641 (-)
FVB/NJ MGP_FVBNJ_G0028326
protein coding gene Chr4:103200134-103219843 (-)
LP/J MGP_LPJ_G0028459
protein coding gene Chr4:108806255-108827091 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028352
protein coding gene Chr4:121412362-121434386 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029003
protein coding gene Chr4:107527331-107548200 (-)
PWK/PhJ MGP_PWKPhJ_G0027403
protein coding gene Chr4:102582545-102602884 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027227
protein coding gene Chr4:104903408-104926004 (-)
WSB/EiJ MGP_WSBEiJ_G0027758
protein coding gene Chr4:107707313-107728827 (-)



Homology
more
  • Human Ortholog
    CPT2, carnitine palmitoyltransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPT2, carnitine palmitoyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPT1, CPTASE, IIAE4
  • Links
    NCBI Gene ID: 1376
    neXtProt AC: NX_P23786
    UniProt: P23786

  • Chr Location
    1p32.3; chr1:53196429-53214197 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CPT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12896 NCBI Gene Model | MGI Sequence Detail 19608 C57BL/6J ±  kb
    transcript NM_009949 RefSeq | MGI Sequence Detail 2366 C57BL/6  
    polypeptide P52825 UniProt | EBI | MGI Sequence Detail 658 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • EC
    • InterPro Domains
      IPR000542 Acyltransferase ChoActase/COT/CPT
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 3
      cDNA 100
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38220, MGI:2140234
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:16140 Gelb BD, Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993 Dec;18(3):651-5
    • Latest
      J:266036 Divakaruni AS, et al., Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab. 2018 Sep 4;28(3):490-503.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory