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Cpt2 Gene Detail
Summary
  • Symbol
    Cpt2
  • Name
    carnitine palmitoyltransferase 2
  • Synonyms
    CPTII, CPT II
  • Feature Type
    protein coding gene
  • IDs
    MGI:109176
    NCBI Gene: 12896
Location & Maps
more
  • Sequence Map
    Chr4:107903981-107923610 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19630 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 50.18 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CPT2, carnitine palmitoyltransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CPT2, carnitine palmitoyltransferase 2
    Orthology source: HomoloGene
  • Synonyms
    CPT1, CPTASE, IIAE4
  • Links
    NCBI Gene ID: 1376
    neXtProt AC: NX_P23786

  • Chr Location
    1p32; chr1:53196429-53214197 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with human CPT2 associations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Cpt2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009301 VEGA Gene Model | MGI Sequence Detail 19630 C57BL/6J ±  kb
transcript OTTMUST00000021110 VEGA | MGI Sequence Detail 2372 Not Applicable  
polypeptide OTTMUSP00000009669 VEGA | MGI Sequence Detail 658 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    94 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000005838 carnitine O-palmitoyltransferase 2, mitochondrial
  • EC
  • InterPro Domains
    IPR000542 Acyltransferase ChoActase/COT/CPT
Molecular
Reagents
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  • All nucleic 105
    Genomic 3
    cDNA 99
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-38220, MGI:2140234
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:16140 Gelb BD, Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993 Dec;18(3):651-5
  • Latest
    J:222220 Iso T, et al., Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2549-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory