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Cpt2
Gene Detail
Symbol

Name
ID
Cpt2
carnitine palmitoyltransferase 2
MGI:109176
Synonyms
CPTII, CPT II
Feature Type
protein coding gene
Genetic Map
Chromosome 4
50.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:107903981-107923610 bp, - strand
From VEGA annotation of GRCm38

  19630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CPT2
Protein SuperFamily: carnitine O-acetyltransferase
Gene Tree: Cpt2

Human
homologs
CPT2, carnitine palmitoyltransferase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1376
neXtProt AC: NX_P23786

Human Synonyms: CPT1, CPTASE, IIAE4

Human Chr (Location): 1p32; chr1:53196429-53214197 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human CPT2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Genomic Mutations involving Cpt2 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cpt2 interacts with 62 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process fatty acid metabolic process, lipid metabolic process, ...
Component membrane, mitochondrial inner membrane, ...
Function carnitine O-palmitoyltransferase activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (144)    Tissues (130)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 137
RT-PCR 7
cDNA source data(99)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cpt2    NEW 
Molecular
reagents
All nucleic(105) Genomic(3) cDNA(99) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000009301 (Evidence)
Ensembl Gene Model ENSMUSG00000028607 (Evidence)
Entrez Gene 12896 (Evidence)
UniGene 307620
DFCI TC1574910
DoTS DT.101226832, DT.94304264
NIA Mouse Gene Index U025349
EC 2.3.1.21
Consensus CDS Project CCDS18443.1
International Mouse Phenotyping Consortium Status Cpt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009301 VEGA Gene Model | MGI Sequence Detail 19630 C57BL/6J ±  kb
transcript OTTMUST00000021110 VEGA | MGI Sequence Detail 2372 Not Applicable 
polypeptide OTTMUSP00000009669 VEGA | MGI Sequence Detail 658 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000542 Acyltransferase ChoActase/COT/CPT
Protein Ontology PR:000005838 carnitine O-palmitoyltransferase 2, mitochondrial
References
(Earliest) J:16140 Gelb BD, Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993 Dec;18(3):651-5
(Latest) J:201804 Breckenridge RA, et al., Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism. PLoS Biol. 2013 Sep;11(9):e1001666
All references(50)
Other
accession IDs
MGD-MRK-38220, MGI:2140234

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory