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Dab2 Gene Detail
Summary
  • Symbol
    Dab2
  • Name
    disabled 2, mitogen-responsive phosphoprotein
  • Synonyms
    5730435J12Rik, D15Wsu122e, D630005B22Rik, p96
  • Feature Type
    protein coding gene
  • IDs
    MGI:109175
    NCBI Gene: 13132
  • Gene Overview
    MyGene.info: DAB2
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:6299788-6440712 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 2.15 cM, cytoband A2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    602 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109175
protein coding gene Chr15:6299788-6440715 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021695
protein coding gene Chr15:3251791-3409978 (+)
A/J MGP_AJ_G0021656
protein coding gene Chr15:3218989-3361062 (+)
AKR/J MGP_AKRJ_G0021634
protein coding gene Chr15:3214396-3371282 (+)
BALB/cJ MGP_BALBcJ_G0021663
protein coding gene Chr15:3132594-3279402 (+)
C3H/HeJ MGP_C3HHeJ_G0021439
protein coding gene Chr15:3248495-3398792 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022102
protein coding gene Chr15:3412063-3565795 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019639
protein coding gene Chr15:2885386-3023530 (+)
CAST/EiJ MGP_CASTEiJ_G0020955
protein coding gene Chr15:3226913-3379295 (+)
CBA/J MGP_CBAJ_G0021408
protein coding gene Chr15:3448286-3620727 (+)
DBA/2J MGP_DBA2J_G0021532
protein coding gene Chr15:3154673-3296885 (+)
FVB/NJ MGP_FVBNJ_G0021510
protein coding gene Chr15:3070550-3216898 (+)
LP/J MGP_LPJ_G0021600
protein coding gene Chr15:3180588-3341466 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021535
protein coding gene Chr15:3672171-3831360 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022125
protein coding gene Chr15:3236217-3392799 (+)
PWK/PhJ MGP_PWKPhJ_G0020698
protein coding gene Chr15:3145718-3293121 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020536
protein coding gene Chr15:3154751-3310462 (+)
WSB/EiJ MGP_WSBEiJ_G0021011
protein coding gene Chr15:3161611-3309868 (+)



Homology
more
  • Human Ortholog
    DAB2, DAB2, clathrin adaptor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAB2, DAB2, clathrin adaptor protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DOC2, DOC-2
  • Links
    NCBI Gene ID: 1601
    neXtProt AC: NX_P98082
    UniProt: P98082

  • Chr Location
    5p13.1; chr5:39371674-39425233 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1026
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DAB2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 5 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit abnormal primitive endoderm structure and/or function, lack a proamniotic cavity and die prior to embryonic day 9.5. A conditional mutant survives, but shows kidney proximal tubule abnormality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022150 Ensembl Gene Model | MGI Sequence Detail 140925 C57BL/6J ±  kb
    transcript ENSMUST00000080880 Ensembl | MGI Sequence Detail 4663 Not Applicable  
    polypeptide ENSMUSP00000079689 Ensembl | MGI Sequence Detail 766 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 248
      Genomic 1
      cDNA 241
      Primer pair 6

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-35708, MGD-MRK-38219, MGI:107243, MGI:1917805, MGI:2145932, MGI:2146101, MGI:3045240
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 31
      Gene Ontology 30
      Phenotypes 19
    • Earliest
      J:37850 Xu XX, et al., Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem. 1995 Jun 9;270(23):14184-91
    • Latest
      J:260470 Meng Y, et al., GATA6 phosphorylation by Erk1/2 propels exit from pluripotency and commitment to primitive endoderm. Dev Biol. 2018 Apr 1;436(1):55-65

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory