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Dab2 Gene Detail
Summary
  • Symbol
    Dab2
  • Name
    disabled 2, mitogen-responsive phosphoprotein
  • Synonyms
    5730435J12Rik, D15Wsu122e, D630005B22Rik, p96
  • Feature Type
    protein coding gene
  • IDs
    MGI:109175
    NCBI Gene: 13132
  • Gene Overview
    MyGene.info: DAB2
Location & Maps
more
  • Sequence Map
    Chr15:6299788-6440712 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      140925 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 2.15 cM, cytoband A2
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    DAB2, DAB2, clathrin adaptor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DAB2, DAB2, clathrin adaptor protein
    Orthology source: HomoloGene
  • Synonyms
    DOC2, DOC-2
  • Links
    NCBI Gene ID: 1601
    neXtProt AC: NX_P98082

  • Chr Location
    5p13.1; chr5:39371674-39425233 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1026
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DAB2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 5 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit abnormal primitive endoderm structure and/or function, lack a proamniotic cavity and die prior to embryonic day 9.5. A conditional mutant survives, but shows kidney proximal tubule abnormality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033430 VEGA Gene Model | MGI Sequence Detail 140925 C57BL/6J ±  kb
transcript OTTMUST00000083998 VEGA | MGI Sequence Detail 4663 Not Applicable  
polypeptide OTTMUSP00000045200 VEGA | MGI Sequence Detail 766 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    602 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 245
    Genomic 1
    cDNA 239
    Primer pair 5

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-35708, MGD-MRK-38219, MGI:107243, MGI:1917805, MGI:2145932, MGI:2146101, MGI:3045240
References
more
  • Summaries
    All 91
    Developmental Gene Expression 26
    Gene Ontology 30
    Phenotypes 17
  • Earliest
    J:37850 Xu XX, et al., Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product. J Biol Chem. 1995 Jun 9;270(23):14184-91
  • Latest
    J:231758 Tao W, et al., Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol. J Lipid Res. 2016 May;57(5):809-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory