Dspp
Gene Detail

Symbol Name ID

Dspp dentin sialophosphoprotein MGI:109172

Synonyms

Dmp3, Dpp, Dsp

Feature Type

protein coding gene

Genetic Map

Chromosome 5

50.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:104170712-104180127 bp, + strand From VEGA annotation of GRCm38   9416 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56286  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Dspp

Human homologs

Human Homolog		DSPP, dentin sialophosphoprotein
NCBI Gene ID		1834
neXtProt AC		NX_Q9NZW4
Human Synonyms		DFNA39, DGI1, DMP3, DPP, DSP, DTDP2
Human Chr (Location)		4q21.3; chr4:88529681-88538025 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human DSPP

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Aging mice homozygous for a reporter/null allele display tooth abnormalities, including enlarged pulp cavities, a widened predentin zone, dentin hypomineralization, pulp exposure, and occasional brittle incisors.

 
Human Diseases Modeled Using Mouse Dspp (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	biomineral tissue development, cellular response to cell-matrix adhesion
Component	extracellular matrix, extracellular region, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (31)    Tissues (10)    Images (3)
Theiler Stages: 22, 25, 28

Assay Type	Results
RNA in situ	29
Northern blot	2

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(5) cDNA(11) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000042402 (Evidence)
Ensembl Gene Model	ENSMUSG00000053268 (Evidence)
Entrez Gene	666279 (Evidence)
UniGene	319832
DFCI	TC1592839
DoTS	DT.110655773, DT.110655774, DT.87034810
Consensus CDS Project	CCDS39190.1
International Mouse Knockout Project Status	Dspp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042402	VEGA Gene Model | MGI Sequence Detail	9416	C57BL/6J
transcript	OTTMUST00000111788	VEGA | MGI Sequence Detail	4431	Not Applicable
polypeptide	OTTMUSP00000062668	VEGA | MGI Sequence Detail	945	Not Applicable

All sequences(22) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(129 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000006712	dentin sialophosphoprotein

References

(Earliest) J:37481 Ritchie HH, et al., Partial cDNA sequencing of mouse dentine sialoprotein and detection of its specific expression by odontoblasts. Arch Oral Biol. 1996 Jun;41(6):571-5
(Latest) J:190409 Zhu Q, et al., Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis. J Biol Chem. 2012 Aug 31;287(36):30426-35
All references(59)

Other accession IDs

MGD-MRK-38216