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Dspp Gene Detail
Summary
  • Symbol
    Dspp
  • Name
    dentin sialophosphoprotein
  • Synonyms
    Dmp3, Dpp, Dsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:109172
    NCBI Gene: 666279
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:104170712-104180127 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.59 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109172
protein coding gene Chr5:104170703-104180127 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029810
protein coding gene Chr5:105852228-105861787 (+)
A/J MGP_AJ_G0029774
protein coding gene Chr5:101861853-101871026 (+)
AKR/J MGP_AKRJ_G0029722
protein coding gene Chr5:105155071-105164211 (+)
BALB/cJ MGP_BALBcJ_G0029786
protein coding gene Chr5:102928932-102938591 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0030241
protein coding gene Chr5:110177183-110186598 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027476
protein coding gene Chr5:96993424-97002985 (+)
CAST/EiJ MGP_CASTEiJ_G0028920
protein coding gene Chr5:104271410-104281207 (+)
CBA/J MGP_CBAJ_G0029479
protein coding gene Chr5:114010747-114020074 (+)
DBA/2J MGP_DBA2J_G0029623
protein coding gene Chr5:102053284-102062699 (+)
FVB/NJ MGP_FVBNJ_G0029582
protein coding gene Chr5:100843357-100852471 (+)
LP/J MGP_LPJ_G0029711
protein coding gene Chr5:106414916-106426054 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029611
protein coding gene Chr5:118940716-118951711 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030274
protein coding gene Chr5:104685119-104694508 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0028473
protein coding gene Chr5:102340848-102350231 (+)
WSB/EiJ MGP_WSBEiJ_G0028998
protein coding gene Chr5:105063305-105072688 (+)



Homology
more
  • Human Ortholog
    DSPP, dentin sialophosphoprotein
  • Human Ortholog
    DSPP, dentin sialophosphoprotein
    Orthology source: HGNC
  • Synonyms
    DFNA39, DGI1, DMP3, DPP, DSP
  • Links
    NCBI Gene ID: 1834
    neXtProt AC: NX_Q9NZW4
    UniProt: Q9NZW4

  • Chr Location
    4q22.1; chr4:87608529-87616873 (+)  GRCh38.p7

  • HCOP
    human homology predictions: DSPP
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Dspp mouse models; 2 with human DSPP associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 4 genetic backgrounds
    4 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Aging mice homozygous for a reporter/null allele display tooth abnormalities, including enlarged pulp cavities, a widened predentin zone, dentin hypomineralization, pulp exposure, and occasional brittle incisors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053268 Ensembl Gene Model | MGI Sequence Detail 9416 C57BL/6J ±  kb
    transcript ENSMUST00000112771 Ensembl | MGI Sequence Detail 4431 Not Applicable  
    polypeptide ENSMUSP00000108391 Ensembl | MGI Sequence Detail 945 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 5
      cDNA 12
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38216
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 40
      Diseases 2
      Gene Ontology 12
      Phenotypes 31
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261898 Zhang H, et al., Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice. PLoS One. 2018;13(4):e0195854

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory