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Dspp Gene Detail
Summary
  • Symbol
    Dspp
  • Name
    dentin sialophosphoprotein
  • Synonyms
    Dmp3, Dpp, Dsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:109172
    NCBI Gene: 666279
Location & Maps
more
  • Sequence Map
    Chr5:104170712-104180127 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9416 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.59 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DSPP, dentin sialophosphoprotein
  • Human Ortholog
    DSPP, dentin sialophosphoprotein
    Orthology source: HGNC
  • Synonyms
    DFNA39, DGI1, DMP3, DPP, DSP
  • Links
    NCBI Gene ID: 1834
    neXtProt AC: NX_Q9NZW4

  • Chr Location
    4q21.3; chr4:87608529-87616873 (+)  GRCh38.p2

  • HCOP
    human homology predictions: DSPP
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Dspp mouse models; 4 with human DSPP associations

Human Disease Mouse Models
       Dentinogenesis Imperfecta, Shields Type III   OMIM: 125500 View 1 model
       Deafness, Autosomal Dominant 39, with Dentinogenesis Imperfecta 1   OMIM: 605594
Dentin Dysplasia, Type II; DTDP2   OMIM: 125420
Dentinogenesis Imperfecta 1; DGI1   OMIM: 125490
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 3 genetic backgrounds
    4 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Transgenic
    2
  • Genomic Mutations
    3 involving Dspp
  • Incidental Mutations
Aging mice homozygous for a reporter/null allele display tooth abnormalities, including enlarged pulp cavities, a widened predentin zone, dentin hypomineralization, pulp exposure, and occasional brittle incisors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042402 VEGA Gene Model | MGI Sequence Detail 9416 C57BL/6J ±  kb
transcript OTTMUST00000111788 VEGA | MGI Sequence Detail 4431 Not Applicable  
polypeptide OTTMUSP00000062668 VEGA | MGI Sequence Detail 945 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    142 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006712 dentin sialophosphoprotein
Molecular
Reagents
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  • All nucleic 19
    Genomic 5
    cDNA 11
    Primer pair 1
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38216
References
more
  • Summaries
    All 64
    Developmental Gene Expression 32
    Diseases 1
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:37481 Ritchie HH, et al., Partial cDNA sequencing of mouse dentine sialoprotein and detection of its specific expression by odontoblasts. Arch Oral Biol. 1996 Jun;41(6):571-5
  • Latest
    J:233764 Gullard A, et al., MEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation. J Histochem Cytochem. 2016 Apr;64(4):224-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory