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Gngt1
Gene Detail
Symbol

Name
ID
Gngt1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
MGI:109165
Synonyms
Gng1, G(y)1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
1.81 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:3993797-3997436 bp, + strand
From VEGA annotation of GRCm38

  3640 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7738  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: GTP-binding regulatory protein gamma chain
Gene Tree: Gngt1

Human
homologs
Human Homolog GNGT1, guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
NCBI Gene ID 2792
neXtProt AC  NX_P63211
Human Synonyms  GNG1
Human Chr (Location)  7q21.3; chr7:93906508-93911173 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous null mice display markedly reduced flash sensitivity of individual retinal rods and gradual retinal photoreceptor degeneration with loss of most rods by 6 months of age. Homozygous knock-in mice expressing geranylgeranylated rod transducin exhibit impaired properties in light adaptation.
 
Interactions
Gngt1 interacts with 122 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cardiac muscle cell apoptotic process, cellular response to hypoxia, ...
Component heterotrimeric G-protein complex, membrane, ...
Function GTPase activity, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (19)    Tissues (13)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
RT-PCR 5
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034241 (Evidence)
Ensembl Gene ModelENSMUSG00000029663 (Evidence)
Entrez Gene14699 (Evidence)
UniGene95398
DFCITC1585751, TC1595705
DoTSDT.55239065, DT.97410620
NIA Mouse Gene IndexU040652
Consensus CDS ProjectCCDS39418.1
International Mouse Knockout Project StatusGngt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034241 VEGA Gene Model | MGI Sequence Detail 3640 C57BL/6J ±  kb
transcript OTTMUST00000086968 VEGA | MGI Sequence Detail 1178 Not Applicable 
polypeptide OTTMUSP00000047150 VEGA | MGI Sequence Detail 74 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015898 G-protein gamma-like domain
InterPro IPR001770 G-protein, gamma subunit
Protein Ontology PR:000008113 guanine nucleotide-binding protein G(T) subunit gamma-T1
References
(Earliest) J:14657 Gautam N, et al., G protein diversity is increased by associations with a variety of gamma subunits. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7973-7
(Latest) J:197400 Lobanova ES, et al., Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9986-91
All references(39)
Other
accession IDs
MGD-MRK-38209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory