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Gngt1 Gene Detail
Summary
  • Symbol
    Gngt1
  • Name
    guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
  • Synonyms
    Gng1, G(y)1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109165
    NCBI Gene: 14699
  • Gene Overview
    MyGene.info: GNGT1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:3993792-3997436 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 1.81 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109165
protein coding gene Chr6:3989082-3997436 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030424
protein coding gene Chr6:727389-731031 (+)
A/J MGP_AJ_G0030397
protein coding gene Chr6:710011-713642 (+)
AKR/J MGP_AKRJ_G0030324
protein coding gene Chr6:751721-755361 (+)
BALB/cJ MGP_BALBcJ_G0030406
protein coding gene Chr6:704827-708469 (+)
C3H/HeJ MGP_C3HHeJ_G0030120
protein coding gene Chr6:728794-732436 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030861
protein coding gene Chr6:756107-759751 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028072
protein coding gene Chr6:527992-531739 (+)
CAST/EiJ MGP_CASTEiJ_G0029521
protein coding gene Chr6:718893-722561 (+)
CBA/J MGP_CBAJ_G0030098
protein coding gene Chr6:778327-781969 (+)
DBA/2J MGP_DBA2J_G0030242
protein coding gene Chr6:707131-710796 (+)
FVB/NJ MGP_FVBNJ_G0030196
protein coding gene Chr6:711249-714889 (+)
LP/J MGP_LPJ_G0030329
protein coding gene Chr6:720230-723856 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030232
protein coding gene Chr6:836098-839707 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030891
protein coding gene Chr6:692556-696203 (+)
PWK/PhJ MGP_PWKPhJ_G0029236
protein coding gene Chr6:642982-646762 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029072
protein coding gene Chr6:734844-738525 (+)
WSB/EiJ MGP_WSBEiJ_G0029598
protein coding gene Chr6:703899-707542 (+)



Homology
more
  • Human Ortholog
    GNGT1, G protein subunit gamma transducin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GNGT1, G protein subunit gamma transducin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GNG1
  • Links
    NCBI Gene ID: 2792
    neXtProt AC: NX_P63211
    UniProt: P63211

  • Chr Location
    7q21.3; chr7:93906508-93911173 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display markedly reduced flash sensitivity of individual retinal rods and gradual retinal photoreceptor degeneration with loss of most rods by 6 months of age. Homozygous knock-in mice expressing geranylgeranylated rod transducin exhibit impaired properties in light adaptation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029663 Ensembl Gene Model | MGI Sequence Detail 3645 C57BL/6J ±  kb
    transcript ENSMUST00000031673 Ensembl | MGI Sequence Detail 1183 Not Applicable  
    polypeptide ENSMUSP00000031673 Ensembl | MGI Sequence Detail 74 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38209
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:14657 Gautam N, et al., G protein diversity is increased by associations with a variety of gamma subunits. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7973-7
    • Latest
      J:264513 Brooks C, et al., Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice. J Neurosci. 2018 Aug 15;38(33):7248-7254

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory