About   Help   FAQ
Gng5 Gene Detail
Summary
  • Symbol
    Gng5
  • Name
    guanine nucleotide binding protein (G protein), gamma 5
  • Synonyms
    G(y)5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109164
    NCBI Gene: 14707
  • Gene Overview
    MyGene.info: GNG5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:146499836-146505543 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 71.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109164
protein coding gene Chr3:146499807-146505572 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027973
protein coding gene Chr3:150021760-150027542 (+)
A/J MGP_AJ_G0027932
protein coding gene Chr3:144628141-144633906 (+)
AKR/J MGP_AKRJ_G0027898
protein coding gene Chr3:148490822-148498491 (+)
BALB/cJ MGP_BALBcJ_G0027944
protein coding gene Chr3:144453808-144459573 (+)
C3H/HeJ MGP_C3HHeJ_G0027674
protein coding gene Chr3:148858000-148863765 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028387
protein coding gene Chr3:155043501-155050318 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025725
protein coding gene Chr3:139689614-139695451 (+)
CAST/EiJ MGP_CASTEiJ_G0027127
protein coding gene Chr3:148841071-148848255 (+)
CBA/J MGP_CBAJ_G0027649
protein coding gene Chr3:160553491-160559256 (+)
DBA/2J MGP_DBA2J_G0027789
protein coding gene Chr3:143782161-143787926 (+)
FVB/NJ MGP_FVBNJ_G0027756
protein coding gene Chr3:141197988-141203753 (+)
LP/J MGP_LPJ_G0027900
protein coding gene Chr3:151405259-151410971 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027789
protein coding gene Chr3:168831455-168839618 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028446
protein coding gene Chr3:148078499-148084355 (+)
PWK/PhJ MGP_PWKPhJ_G0026850
protein coding gene Chr3:143637513-143643962 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026678
protein coding gene Chr3:146243294-146249923 (+)
WSB/EiJ MGP_WSBEiJ_G0027207
protein coding gene Chr3:149054712-149060477 (+)



Homology
more
  • Human Ortholog
    GNG5, G protein subunit gamma 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GNG5, G protein subunit gamma 5
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2787
    neXtProt AC: NX_P63218
    UniProt: P63218

  • Chr Location
    1p22.3; chr1:84498323-84506579 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3861
    1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GNG5
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal headfolds, hypoplastic pharyngeal arches, severe cardiac defects including absence of formation of the right ventricle and outflow tract, and complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14707 NCBI Gene Model | MGI Sequence Detail 5708 C57BL/6J ±  kb
    transcript NM_010318 RefSeq | MGI Sequence Detail 535 C57BL/6  
    polypeptide NP_034448 RefSeq | MGI Sequence Detail 68 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-38208
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:34526 Williams CJ, et al., G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development. Mol Reprod Dev. 1996 Jul;44(3):315-23
    • Latest
      J:215128 Moon AM, et al., Disruption of G-protein gamma5 subtype causes embryonic lethality in mice. PLoS One. 2014;9(3):e90970

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory