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Gng5 Gene Detail
Summary
  • Symbol
    Gng5
  • Name
    guanine nucleotide binding protein (G protein), gamma 5
  • Synonyms
    G(y)5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109164
    NCBI Gene: 14707
  • Gene Overview
    MyGene.info: GNG5
Location & Maps
more
  • Sequence Map
    Chr3:146499807-146505572 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5766 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GNG5, G protein subunit gamma 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GNG5, G protein subunit gamma 5
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 2787
    neXtProt AC: NX_P63218

  • Chr Location
    1p22; chr1:84498323-84506579 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3861
    1 human;2 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GNG5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    9
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Gng5
  • Incidental Mutations
Mice homozygous for a null allele exhibit abnormal headfolds, hypoplastic pharyngeal arches, severe cardiac defects including absence of formation of the right ventricle and outflow tract, and complete embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029572 VEGA Gene Model | MGI Sequence Detail 5766 C57BL/6J ±  kb
transcript OTTMUST00000073335 VEGA | MGI Sequence Detail 593 Not Applicable  
polypeptide OTTMUSP00000037935 VEGA | MGI Sequence Detail 68 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    23 from dbSNP Build 142
Protein
Information
less
  • Protein Ontology
    PR:000008110 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-38208
References
more
  • Summaries
    All 29
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:34526 Williams CJ, et al., G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development. Mol Reprod Dev. 1996 Jul;44(3):315-23
  • Latest
    J:215128 Moon AM, et al., Disruption of G-protein gamma5 subtype causes embryonic lethality in mice. PLoS One. 2014;9(3):e90970

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory