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Gng8 Gene Detail
Summary
  • Symbol
    Gng8
  • Name
    guanine nucleotide binding protein (G protein), gamma 8
  • Synonyms
    G(y)8
  • Feature Type
    protein coding gene
  • IDs
    MGI:109163
    NCBI Gene: 14709
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16891786-16895436 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109163
protein coding gene Chr7:16891736-16895451 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031721
protein coding gene Chr7:14659776-14663388 (+)
A/J MGP_AJ_G0031693
protein coding gene Chr7:14372517-14376167 (+)
AKR/J MGP_AKRJ_G0031618
protein coding gene Chr7:14711956-14715606 (+)
BALB/cJ MGP_BALBcJ_G0031700
protein coding gene Chr7:14480646-14484549 (+)
C3H/HeJ MGP_C3HHeJ_G0031422
protein coding gene Chr7:14898155-14901767 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032166
protein coding gene Chr7:15376264-15379914 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029245
protein coding gene Chr7:15908941-15912653 (+)
CAST/EiJ MGP_CASTEiJ_G0030773
protein coding gene Chr7:11672502-11676156 (+)
CBA/J MGP_CBAJ_G0031381
protein coding gene Chr7:15899986-15903598 (+)
DBA/2J MGP_DBA2J_G0031537
protein coding gene Chr7:14263617-14267267 (+)
FVB/NJ MGP_FVBNJ_G0031493
protein coding gene Chr7:14164104-14167763 (+)
LP/J MGP_LPJ_G0031622
protein coding gene Chr7:14893092-14896704 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031528
protein coding gene Chr7:15811439-15815090 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032195
protein coding gene Chr7:14491778-14495428 (+)
PWK/PhJ MGP_PWKPhJ_G0030497
protein coding gene Chr7:11785261-11788897 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030324
protein coding gene Chr7:9415651-9419806 (+)
WSB/EiJ MGP_WSBEiJ_G0030870
protein coding gene Chr7:14559221-14562858 (+)



Homology
more
  • Human Ortholog
    GNG8, G protein subunit gamma 8
  • Vertebrate Orthologs
    6
  • Human Ortholog
    GNG8, G protein subunit gamma 8
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 94235
    neXtProt AC: NX_Q9UK08
    UniProt: Q9UK08

  • Chr Location
    19q13.32; chr19:46633953-46639326 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in a slow but progressive loss of vomeronasal neurons, impairment of specific vomeronasal-mediated behaviors such as maternal and intermale aggression, and reduced physiological responses to pheromonal stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063594 Ensembl Gene Model | MGI Sequence Detail 3651 C57BL/6J ±  kb
    transcript ENSMUST00000078182 Ensembl | MGI Sequence Detail 910 Not Applicable  
    polypeptide ENSMUSP00000077314 Ensembl | MGI Sequence Detail 70 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38207
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:34526 Williams CJ, et al., G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development. Mol Reprod Dev. 1996 Jul;44(3):315-23
    • Latest
      J:237342 Assens A, et al., Alteration of Nrp1 signaling at different stages of olfactory neuron maturation promotes glomerular shifts along distinct axes in the olfactory bulb. Development. 2016 Oct 15;143(20):3817-3825

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory