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Gng8
Gene Detail
Symbol

Name
ID
Gng8
guanine nucleotide binding protein (G protein), gamma 8
MGI:109163
Synonyms
G(y)8
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:16891786-16895435 bp, + strand
From Ensembl annotation of GRCm38

  3650 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:7740  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNG8
Protein SuperFamily: GTP-binding regulatory protein gamma chain
Gene Tree: Gng8

Human
homologs
GNG8, guanine nucleotide binding protein (G protein), gamma 8
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 94235
neXtProt AC: NX_Q9UK08

Human Chr (Location): 19q13.32; chr19:46633934-46635534 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gng8 interacts with 9 markers (Mir1a-1, Mir1a-2, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cellular response to pheromone, G-protein coupled receptor signaling pathway, ...
Component heterotrimeric G-protein complex, membrane, ...
Function signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 5
cDNA source data(8)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000063594 (Evidence)
Entrez Gene 14709 (Evidence)
UniGene 103770
DFCI TC1699580
DoTS DT.483722, DT.97343201, DT.55193053
NIA Mouse Gene Index U007720
Consensus CDS Project CCDS20856.1
International Mouse Phenotyping Consortium Status Gng8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063594 Ensembl Gene Model | MGI Sequence Detail 3650 C57BL/6J ±  kb
transcript ENSMUST00000078182 Ensembl | MGI Sequence Detail 920 Not Applicable 
polypeptide ENSMUSP00000077314 Ensembl | MGI Sequence Detail 70 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015898 G-protein gamma-like domain
InterPro IPR001770 G-protein, gamma subunit
Protein Ontology PR:000008112 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
References
(Earliest) J:34526 Williams CJ, et al., G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development. Mol Reprod Dev. 1996 Jul;44(3):315-23
(Latest) J:212780 Montani G, et al., Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. J Physiol. 2013 Aug 15;591(Pt 16):3949-62
All references(29)
Other
accession IDs
MGD-MRK-38207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory