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Gpam Gene Detail
Summary
  • Symbol
    Gpam
  • Name
    glycerol-3-phosphate acyltransferase, mitochondrial
  • Synonyms
    GPAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109162
    NCBI Gene: 14732
  • Gene Overview
    MyGene.info: GPAM
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:55069734-55099451 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 50.81 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109162
protein coding gene Chr19:55067635-55127233 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025254
protein coding gene Chr19:55327591-55364739 (-)
A/J MGP_AJ_G0025230
protein coding gene Chr19:52603779-52639068 (-)
AKR/J MGP_AKRJ_G0025199
protein coding gene Chr19:54262920-54292204 (-)
BALB/cJ MGP_BALBcJ_G0025225
protein coding gene Chr19:52669213-52698544 (-)
C3H/HeJ MGP_C3HHeJ_G0024985
protein coding gene Chr19:54486984-54523249 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025668
protein coding gene Chr19:56678023-56715762 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023080
protein coding gene Chr19:51539072-51569734 (-)
CAST/EiJ MGP_CASTEiJ_G0024450
protein coding gene Chr19:54481088-54513424 (-)
CBA/J MGP_CBAJ_G0024965
protein coding gene Chr19:59485969-59523593 (-)
DBA/2J MGP_DBA2J_G0025097
protein coding gene Chr19:52403808-52433708 (-)
FVB/NJ MGP_FVBNJ_G0025058
protein coding gene Chr19:52101749-52139606 (-)
LP/J MGP_LPJ_G0025183
protein coding gene Chr19:55204800-55234443 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025091
protein coding gene Chr19:58860516-58894817 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025726
protein coding gene Chr19:54469743-54504677 (-)
PWK/PhJ MGP_PWKPhJ_G0024198
protein coding gene Chr19:52324650-52362855 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024001
protein coding gene Chr19:53149373-53181477 (-)
WSB/EiJ MGP_WSBEiJ_G0024520
protein coding gene Chr19:54597649-54628813 (-)



Homology
more
  • Human Ortholog
    GPAM, glycerol-3-phosphate acyltransferase, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPAM, glycerol-3-phosphate acyltransferase, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPAT, GPAT1
  • Links
    NCBI Gene ID: 57678
    neXtProt AC: NX_Q9HCL2
    UniProt: Q9HCL2

  • Chr Location
    10q25.2; chr10:112149864-112215395 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice weighed less than controls and showed reduced triacylglycerol levels in the liver and plasma. The glycerolipid fatty acid composition is also disrupted in mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024978 Ensembl Gene Model | MGI Sequence Detail 29718 C57BL/6J ±  kb
    transcript ENSMUST00000061856 Ensembl | MGI Sequence Detail 3832 Not Applicable  
    polypeptide ENSMUSP00000057635 Ensembl | MGI Sequence Detail 827 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008159 glycerol-3-phosphate acyltransferase 1, mitochondrial
    • EC
    • InterPro Domains
      IPR028354 Glycerol-3-phosphate acyltransferase, PlsB
      IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
      IPR002123 Phospholipid/glycerol acyltransferase
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 58
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38206
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Gene Ontology 18
      Phenotypes 17
    • Earliest
      J:24536 Shin DH, et al., Transcriptional regulation of p90 with sequence homology to Escherichia coli glycerol-3-phosphate acyltransferase. J Biol Chem. 1991 Dec 15;266(35):23834-9
    • Latest
      J:235644 Wu Y, et al., Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory