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Gpam
Gene Detail
Symbol

Name
ID
Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
MGI:109162
Synonyms
GPAT1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
50.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:55069734-55099451 bp, - strand
From VEGA annotation of GRCm38

  29718 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7343  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GPAM
Protein SuperFamily: glycerol-3-phosphate O-acyltransferase/dihydroxyacetone phosphate acyltransferase
Gene Tree: Gpam

Human
homologs
GPAM, glycerol-3-phosphate acyltransferase, mitochondrial
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57678
neXtProt AC: NX_Q9HCL2

Human Synonyms: GPAT, GPAT1

Human Chr (Location): 10q25.2; chr10:112149864-112215395 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice weighed less than controls and showed reduced triacylglycerol levels in the liver and plasma. The glycerolipid fatty acid composition is also disrupted in mutant mice.
 
Interactions
Gpam interacts with 181 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (199)    Tissues (150)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 199
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GPAM ; Xenbase gpam    NEW 
Molecular
reagents
All nucleic(60) Genomic(1) cDNA(57) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033406 (Evidence)
Ensembl Gene Model ENSMUSG00000024978 (Evidence)
Entrez Gene 14732 (Evidence)
UniGene 210196
DFCI TC1582412, TC1603341, TC1628149, TC1642645
DoTS DT.102557304, DT.55154483, DT.91383273, DT.91482487
NIA Mouse Gene Index U039161
EC 2.3.1.15
Consensus CDS Project CCDS29906.1
International Mouse Phenotyping Consortium Status Gpam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033406 VEGA Gene Model | MGI Sequence Detail 29718 C57BL/6J ±  kb
transcript OTTMUST00000083871 VEGA | MGI Sequence Detail 3832 Not Applicable 
polypeptide OTTMUSP00000045122 VEGA | MGI Sequence Detail 827 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(11) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(232 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028354 Glycerol-3-phosphate acyltransferase, PlsB
InterPro IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
InterPro IPR002123 Phospholipid/glycerol acyltransferase
Protein Ontology PR:000008159 glycerol-3-phosphate acyltransferase 1, mitochondrial
References
(Earliest) J:24536 Shin DH, et al., Transcriptional regulation of p90 with sequence homology to Escherichia coli glycerol-3-phosphate acyltransferase. J Biol Chem. 1991 Dec 15;266(35):23834-9
(Latest) J:218479 Faris R, et al., Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential for murine CD4(+) T cell metabolic activation. Biochim Biophys Acta. 2014 Oct;1842(10):1475-82
All references(59)
Other
accession IDs
MGD-MRK-38206

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory