About   Help   FAQ
Elavl3
Gene Detail
 Symbol
Name
ID
Elavl3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)
MGI:109157
Synonyms 2600009P04Rik, Huc, mHuC
Feature Type protein coding gene
Genetic Map
Chromosome 9
8.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:22015005-22052023 bp, - strand
From NCBI annotation of GRCm38

  37019 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31035  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Elavl3

Human
homologs
Human Homolog ELAVL3, ELAV like neuron-specific RNA binding protein 3
NCBI Gene ID 1995
neXtProt AC  NX_Q14576
Human Synonyms  HUC, HUCL, PLE21
Human Chr (Location)  19p13.2; chr19:11451326-11481046 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit strain-specific preweaning lethality, abnormal cortical hypersynchronization and non-convulsive electropgraphic seizure. Mice heterozygous for the allele exhibit abnormal brain wave pattern and spike wave discharge.
 
Interactions
Elavl3 interacts with 341 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cell differentiation, multicellular organismal development, ...
Function AU-rich element binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (73 records)
Data Summary: Results (72)    Tissues (46)    Images (24)
Theiler Stages: 19, 20, 21, 23, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 62
RT-PCR 2
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(14) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000003410 (Evidence)
Entrez Gene15571 (Evidence)
DFCITC1583165, TC1599484, TC1602877, TC1774984
DoTSDT.101300676, DT.110584966, DT.60103528, DT.87072317, DT.97410342
NIA Mouse Gene IndexU030599
PDB1D8Z, 1D9A, 1FNX
Consensus CDS ProjectCCDS52741.1
International Mouse Knockout Project StatusElavl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15571 NCBI Gene Model | MGI Sequence Detail 37019 C57BL/6J ±  kb
transcript NM_010487 RefSeq | MGI Sequence Detail 5027 C57BL/6 
polypeptide Q60900 UniProt | EBI | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(46 from dbSNP Build 137)    SNPs within 2kb including multiple locations(48)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR002343 Paraneoplastic encephalomyelitis antigen
InterPro IPR000504 RNA recognition motif domain
InterPro IPR006548 Splicing factor ELAV/HuD
Protein Ontology PR:000007018 ELAV-like protein 3
Graphical View of Protein Domain Structure
References (Earliest) J:31495 Abe R, et al., Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen. DNA Res. 1994;1(4):175-80
(Latest) J:208765 Wittmann W, et al., Cux2 acts as a critical regulator for neurogenesis in the olfactory epithelium of vertebrates. Dev Biol. 2014 Apr 1;388(1):35-47
All references(108)
Other
accession IDs
MGD-MRK-38201, MGI:1913822

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory