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Isl2 Gene Detail
Summary
  • Symbol
    Isl2
  • Name
    insulin related protein 2 (islet 2)
  • Synonyms
    3110001N10Rik, islet 2, islet-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109156
    NCBI Gene: 104360
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:55538672-55546180 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 30.13 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109156
protein coding gene Chr9:55538672-55547667 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034843
protein coding gene Chr9:54656841-54664351 (+)
A/J MGP_AJ_G0034824
protein coding gene Chr9:52881624-52889135 (+)
AKR/J MGP_AKRJ_G0034753
protein coding gene Chr9:54094047-54101558 (+)
BALB/cJ MGP_BALBcJ_G0034816
protein coding gene Chr9:52659270-52666778 (+)
C3H/HeJ MGP_C3HHeJ_G0034526
protein coding gene Chr9:54558632-54566143 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035335
protein coding gene Chr9:56160821-56168329 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032247
protein coding gene Chr9:52282725-52290279 (+)
CAST/EiJ MGP_CASTEiJ_G0033847
protein coding gene Chr9:54593102-54645967 (+)
CBA/J MGP_CBAJ_G0034497
protein coding gene Chr9:58126624-58134133 (+)
DBA/2J MGP_DBA2J_G0034656
protein coding gene Chr9:52771190-52778700 (+)
FVB/NJ MGP_FVBNJ_G0034598
protein coding gene Chr9:51974418-51981927 (+)
LP/J MGP_LPJ_G0034739
protein coding gene Chr9:54948237-54955786 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034641
protein coding gene Chr9:59619402-59626913 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035357
protein coding gene Chr9:54109945-54117456 (+)
PWK/PhJ MGP_PWKPhJ_G0033552
protein coding gene Chr9:52771772-52779315 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033387
protein coding gene Chr9:54384655-54433655 (+)
WSB/EiJ MGP_WSBEiJ_G0033960
protein coding gene Chr9:54070027-54077540 (+)



Homology
more
  • Human Ortholog
    ISL2, ISL LIM homeobox 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ISL2, ISL LIM homeobox 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 64843
    neXtProt AC: NX_Q96A47
    UniProt: Q96A47

  • Chr Location
    15q24.3; chr15:76336724-76342476 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 5 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations of this gene result in neonatal lethality, motor neuron migration defects and impaired visceral motor neuron differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032318 Ensembl Gene Model | MGI Sequence Detail 7509 C57BL/6J ±  kb
    transcript ENSMUST00000034869 Ensembl | MGI Sequence Detail 1854 Not Applicable  
    polypeptide ENSMUSP00000034869 Ensembl | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-38200, MGI:1917602
    References
    more
    • Summaries
      All 386
      Developmental Gene Expression 332
      Gene Ontology 8
      Phenotypes 36
    • Earliest
      J:31131 Pfaff SL, et al., Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell. 1996 Jan 26;84(2):309-20
    • Latest
      J:276416 Zhuang M, et al., The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression. Nucleic Acids Res. 2019 May 21;47(9):4765-4777

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory