About   Help   FAQ
Kcnab1
Gene Detail
Symbol

Name
ID
Kcnab1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
MGI:109155
Synonyms
Akr8a8, Kvbeta1.1, mKv(beta)1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
30.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:65109384-65378223 bp, + strand
From VEGA annotation of GRCm38

  268840 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNAB1
Gene Tree: Kcnab1

Human
homologs
KCNAB1, potassium channel, voltage gated subfamily A regulatory beta subunit 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7881
neXtProt AC: NX_Q14722

Human Synonyms: AKR6A3, hKvb3, hKvBeta3, KCNA1B, Kvb1.3, KV-BETA-1

Human Chr (Location): 3q26.1; chr3:156120548-156539138 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene experience some learning defects but are otherwise normal.
 
Interactions
Kcnab1 interacts with 305 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process ion transport, learning or memory, ...
Component axon, cytoplasm, ...
Function 2-hydroxytetrahydrofuran dehydrogenase activity, 3-hydroxymenthone dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (44)    Tissues (44)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 38
RT-PCR 6
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kcnab1 ; ZFIN kcnab1a, kcnab1b    NEW 
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000034877 (Evidence)
Ensembl Gene Model ENSMUSG00000027827 (Evidence)
Entrez Gene 16497 (Evidence)
UniGene 316402
DFCI TC1592509, TC1577096
DoTS DT.101707013, DT.101371998, DT.101371997, DT.60117371, DT.94259608
NIA Mouse Gene Index U003296
EC 1.1.1.-
Consensus CDS Project CCDS38447.1
International Mouse Phenotyping Consortium Status Kcnab1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034877 VEGA Gene Model | MGI Sequence Detail 268840 C57BL/6J ±  kb
transcript OTTMUST00000088645 VEGA | MGI Sequence Detail 3245 Not Applicable 
polypeptide OTTMUSP00000048336 VEGA | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(8) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(1560 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001395 Aldo/keto reductase
InterPro IPR023210 NADP-dependent oxidoreductase domain
InterPro IPR005983 Potassium channel, voltage-dependent, beta subunit, KCNAB
InterPro IPR005400 Potassium channel, voltage-dependent, beta subunit, KCNAB1
InterPro IPR005399 Potassium channel, voltage-dependent, beta subunit, KCNAB-related
Protein Ontology PR:000009251 voltage-gated potassium channel subunit beta-1
References
(Earliest) J:36040 Fink M, et al., A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. J Biol Chem. 1996 Oct 18;271(42):26341-8
(Latest) J:165759 Chiu HS, et al., Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation. Dev Biol. 2010 Aug 15;344(2):1071-87
All references(41)
Other
accession IDs
MGD-MRK-38199

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory