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Ltbp1
Gene Detail
 Symbol
Name
ID
Ltbp1
latent transforming growth factor beta binding protein 1
MGI:109151
Synonyms 9430031G15Rik, b2b1000Clo, LTBP-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
46.24 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:75005568-75392512 bp, + strand
From VEGA annotation of GRCm38

  386945 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:522  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: latent transforming growth factor beta-binding protein
Gene Tree: Ltbp1

Human
homologs
Human Homolog LTBP1, latent transforming growth factor beta binding protein 1
NCBI Gene ID 4052
neXtProt AC  NX_Q14766
Human Chr (Location)  2p22-p21; chr2:32947154-33399509 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic and neonatal lethality associated with defects in the aortic arch and outflow tract.
 
Phenotype Images(15)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process transforming growth factor beta receptor signaling pathway
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, growth factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (275)    Tissues (219)    Images (28)
Theiler Stages: 10, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 261
Northern blot 12
RT-PCR 2
cDNA source data(64)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020204 (Evidence)
Ensembl Gene ModelENSMUSG00000001870 (Evidence)
Entrez Gene268977 (Evidence)
UniGene269747
DFCITC1579579, TC1595656, TC1609559, TC1621984, TC1657642, TC1705231
DoTSDT.101215464, DT.101375147, DT.101737288, DT.103570030, DT.528566, DT.91388068, DT.91576139, DT.94153069, DT.94180610
NIA Mouse Gene IndexU018228
Consensus CDS ProjectCCDS28973.1, CCDS37694.1
International Mouse Knockout Project StatusLtbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020204 VEGA Gene Model | MGI Sequence Detail 386945 C57BL/6J ±  kb
transcript OTTMUST00000047991 VEGA | MGI Sequence Detail 6671 Not Applicable 
polypeptide OTTMUSP00000021889 VEGA | MGI Sequence Detail 1712 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(22) UniProt(4)
Polymorphisms SNPs within 2kb(2616 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017878 TB domain
Protein Ontology PR:000000101 latent TGF-beta-binding protein 1
References (Earliest) J:24946 Yin W, et al., Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3). J Biol Chem. 1995 Apr 28;270(17):10147-60
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(63)
Other
accession IDs
MGD-MRK-38195, MGI:1924572, MGI:5316769

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory