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Ltbp1 Gene Detail
Summary
  • Symbol
    Ltbp1
  • Name
    latent transforming growth factor beta binding protein 1
  • Synonyms
    9430031G15Rik, b2b1000Clo, LTBP-1, Ltbp1L
  • Feature Type
    protein coding gene
  • IDs
    MGI:109151
    NCBI Gene: 268977
  • Gene Overview
    MyGene.info: LTBP1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:75005568-75392512 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 46.24 cM, cytoband E3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2597 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109151
protein coding gene Chr17:75005529-75392967 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024033
protein coding gene Chr17:77690011-78111091 (+)
A/J MGP_AJ_G0023990
protein coding gene Chr17:75276182-75668114 (+)
AKR/J MGP_AKRJ_G0023959
protein coding gene Chr17:76394738-76788631 (+)
BALB/cJ MGP_BALBcJ_G0023992
protein coding gene Chr17:75178078-75577069 (+)
C3H/HeJ MGP_C3HHeJ_G0023756
protein coding gene Chr17:77293875-77695447 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024437
protein coding gene Chr17:80480081-80894001 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021881
protein coding gene Chr17:70891616-71279850 (+)
CAST/EiJ MGP_CASTEiJ_G0023236
protein coding gene Chr17:77835064-78241229 (+)
CBA/J MGP_CBAJ_G0023730
protein coding gene Chr17:83828834-84282519 (+)
DBA/2J MGP_DBA2J_G0023859
protein coding gene Chr17:73853957-74244544 (+)
FVB/NJ MGP_FVBNJ_G0023825
protein coding gene Chr17:73379563-73775568 (+)
LP/J MGP_LPJ_G0023942
protein coding gene Chr17:78454437-78870953 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023853
protein coding gene Chr17:83636401-84057101 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024481
protein coding gene Chr17:76841695-77259373 (+)
PWK/PhJ MGP_PWKPhJ_G0022982
protein coding gene Chr17:73257201-73666766 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022793
protein coding gene Chr17:73580156-74007545 (+)
WSB/EiJ MGP_WSBEiJ_G0023303
protein coding gene Chr17:77716306-78132787 (+)



Homology
more
  • Human Ortholog
    LTBP1, latent transforming growth factor beta binding protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LTBP1, latent transforming growth factor beta binding protein 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4052
    neXtProt AC: NX_Q14766
    UniProt: Q14766

  • Chr Location
    2p22.3; chr2:32947129-33399509 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 6 alleles in 5 genetic backgrounds
    15 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic and neonatal lethality associated with defects in the aortic arch and outflow tract.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001870 Ensembl Gene Model | MGI Sequence Detail 386945 C57BL/6J ±  kb
    transcript ENSMUST00000001927 Ensembl | MGI Sequence Detail 6671 Not Applicable  
    polypeptide ENSMUSP00000001927 Ensembl | MGI Sequence Detail 1712 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 69
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38195, MGI:1924572, MGI:5316769
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 20
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:24946 Yin W, et al., Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3). J Biol Chem. 1995 Apr 28;270(17):10147-60
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory