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Mnt Gene Detail
Summary
  • Symbol
    Mnt
  • Name
    max binding protein
  • Synonyms
    bHLHd3, Rox
  • Feature Type
    protein coding gene
  • IDs
    MGI:109150
    NCBI Gene: 17428
  • Gene Overview
    MyGene.info: MNT
Location & Maps
more
  • Sequence Map
    Chr11:74830920-74845725 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14806 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MNT, MAX network transcriptional repressor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MNT, MAX network transcriptional repressor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHd3, MAD6, MXD6, ROX
  • Links
    NCBI Gene ID: 4335
    neXtProt AC: NX_Q99583

  • Chr Location
    17p13.3; chr17:2384060-2400964 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mnt mouse models

Human Disease Mouse Models
       Miller-Dieker Lissencephaly Syndrome; MDLS   OMIM: 247200 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Targeted
    7
  • Genomic Mutations
    2 involving Mnt
  • Incidental Mutations
    APF , CvDC
Most homozygotes for a targeted null mutation are runted at birth and die within a few days, while mutant fibroblasts show abnormal cell cycling. Those homozygotes that survive are fertile and attain normal Heterozygotes for a conditional mammary epithelial specific knockout develop adenocarcinomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006185 VEGA Gene Model | MGI Sequence Detail 14806 C57BL/6J ±  kb
transcript OTTMUST00000013930 VEGA | MGI Sequence Detail 4590 Not Applicable  
polypeptide OTTMUSP00000006471 VEGA | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    69 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010500 max-binding protein MNT
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 81
    Genomic 3
    cDNA 76
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38194
References
more
  • Summaries
    All 47
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:37853 Hurlin PJ, et al., Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev. 1997 Jan 1;11(1):44-58
  • Latest
    J:192351 Link JM, et al., A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19685-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory