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Mnt
Gene Detail
 Symbol
Name
ID
Mnt
max binding protein
MGI:109150
Synonyms bHLHd3, Rox
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.76 cM, cytoband B-C
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:74830920-74845725 bp, + strand
From VEGA annotation of GRCm38

  14806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7842  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Mnt

Human
homologs
Human Homolog MNT, MAX network transcriptional repressor
NCBI Gene ID 4335
neXtProt AC  NX_Q99583
Human Synonyms  bHLHd3, MAD6, MXD6, ROX
Human Chr (Location)  17p13.3; chr17:2384060-2400964 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(24) Targeted(6)
Incidental mutations (data from APF )
 
Most homozygotes for a targeted null mutation are runted at birth and die within a few days, while mutant fibroblasts show abnormal cell cycling. Those homozygotes that survive are fertile and attain normal Heterozygotes for a conditional mammary epithelial specific knockout develop adenocarcinomas.
 
Interactions
Mnt interacts with 373 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell aging, negative regulation of apoptotic signaling pathway, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (90)    Tissues (87)    Images (4)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 21, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 82
RT-PCR 8
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(81) Genomic(3) cDNA(76) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006185 (Evidence)
Ensembl Gene ModelENSMUSG00000000282 (Evidence)
Entrez Gene17428 (Evidence)
UniGene3759
DFCITC1577716
DoTSDT.60109193
NIA Mouse Gene IndexU012931
Consensus CDS ProjectCCDS25037.1
International Mouse Knockout Project StatusMnt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006185 VEGA Gene Model | MGI Sequence Detail 14806 C57BL/6J ±  kb
transcript OTTMUST00000013930 VEGA | MGI Sequence Detail 4590 Not Applicable 
polypeptide OTTMUSP00000006471 VEGA | MGI Sequence Detail 591 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010500 max-binding protein MNT
References (Earliest) J:37853 Hurlin PJ, et al., Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev. 1997 Jan 1;11(1):44-58
(Latest) J:192351 Link JM, et al., A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19685-90
All references(51)
Other
accession IDs
MGD-MRK-38194

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory