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Oxtr
Gene Detail
Symbol

Name
ID
Oxtr
oxytocin receptor
MGI:109147
Synonyms
OTR
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.27 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:112473684-112489808 bp, - strand
From Ensembl annotation of GRCm38

  16125 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: vasopressin/oxytocin receptor
Gene Tree: Oxtr

Human
homologs
Human Homolog OXTR, oxytocin receptor
NCBI Gene ID 5021
neXtProt AC  NX_P30559
Human Synonyms  OT-R
Human Chr (Location)  3p25; chr3:8750408-8769614 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null females fail to lactate and exhibit decreased maternal behavior. Males exhibit an increase in aggression, hypoactivity and vocalization in response to social isolation, and social amnesia.
 
Interactions
Oxtr interacts with 333 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (22)    Tissues (11)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 11
RT-PCR 11
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000049112 (Evidence)
Entrez Gene18430 (Evidence)
UniGene333310
DFCITC1648318
DoTSDT.521543, DT.101286840
NIA Mouse Gene IndexU067286
Consensus CDS ProjectCCDS39588.1
International Mouse Knockout Project StatusOxtr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049112 Ensembl Gene Model | MGI Sequence Detail 16125 C57BL/6J ±  kb
transcript ENSMUST00000053306 Ensembl | MGI Sequence Detail 4568 Not Applicable 
polypeptide ENSMUSP00000051132 Ensembl | MGI Sequence Detail 388 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR002062 Oxytocin receptor
InterPro IPR001817 Vasopressin receptor
Protein Ontology PR:000001635 oxytocin receptor
References
(Earliest) J:33726 Kaluz S, et al., Heterogeneity in the third intracytoplasmic region of the oxytocin receptor-encoding gene. Gene. 1996 Jun 26;172(2):313-4
(Latest) J:209833 Kim J, et al., Peg3 mutational effects on reproduction and placenta-specific gene families. PLoS One. 2013;8(12):e83359
All references(50)
Other
accession IDs
MGD-MRK-38191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory