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Oxtr Gene Detail
Summary
  • Symbol
    Oxtr
  • Name
    oxytocin receptor
  • Synonyms
    OTR
  • Feature Type
    protein coding gene
  • IDs
    MGI:109147
    NCBI Gene: 18430
  • Gene Overview
    MyGene.info: OXTR
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:112473683-112489943 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16261 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.27 cM, cytoband E3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    OXTR, oxytocin receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    OXTR, oxytocin receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OT-R
  • Links
    NCBI Gene ID: 5021
    neXtProt AC: NX_P30559
    UniProt: P30559

  • Chr Location
    3p25.3; chr3:8748579-8769614 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 5 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null females fail to lactate and exhibit decreased maternal behavior. Males exhibit an increase in aggression, hypoactivity and vocalization in response to social isolation, and social amnesia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000056498 VEGA Gene Model | MGI Sequence Detail 16261 C57BL/6J ±  kb
    transcript OTTMUST00000139539 VEGA | MGI Sequence Detail 4704 Not Applicable  
    polypeptide OTTMUSP00000073206 VEGA | MGI Sequence Detail 388 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      162 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 3
      cDNA 12
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38191
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 45
    • Earliest
      J:33726 Kaluz S, et al., Heterogeneity in the third intracytoplasmic region of the oxytocin receptor-encoding gene. Gene. 1996 Jun 26;172(2):313-4
    • Latest
      J:262705 Latt HM, et al., Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons. Neuroscience. 2018 May 21;379:383-389

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory