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Oxtr
Gene Detail
Symbol

Name
ID
Oxtr
oxytocin receptor
MGI:109147
Synonyms
OTR
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.27 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:112473684-112489808 bp, - strand
From Ensembl annotation of GRCm38

  16125 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: OXTR
Protein SuperFamily: vasopressin/oxytocin receptor
Gene Tree: Oxtr

Human
homologs
OXTR, oxytocin receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5021
neXtProt AC: NX_P30559

Human Synonyms: OT-R

Human Chr (Location): 3p25; chr3:8750408-8854549 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Spontaneous(1) Targeted(8)
Genomic Mutations involving Oxtr (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null females fail to lactate and exhibit decreased maternal behavior. Males exhibit an increase in aggression, hypoactivity and vocalization in response to social isolation, and social amnesia.
 
Interactions
Oxtr interacts with 333 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (22)    Tissues (11)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 11
RT-PCR 11
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN oxtr    NEW 
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000049112 (Evidence)
Entrez Gene 18430 (Evidence)
UniGene 333310
DFCI TC1648318
DoTS DT.101286840, DT.521543
NIA Mouse Gene Index U067286
Consensus CDS Project CCDS39588.1
International Mouse Phenotyping Consortium Status Oxtr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049112 Ensembl Gene Model | MGI Sequence Detail 16125 C57BL/6J ±  kb
transcript ENSMUST00000053306 Ensembl | MGI Sequence Detail 4568 Not Applicable 
polypeptide ENSMUSP00000051132 Ensembl | MGI Sequence Detail 388 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR002062 Oxytocin receptor
InterPro IPR001817 Vasopressin receptor
Protein Ontology PR:000001635 oxytocin receptor
References
(Earliest) J:37690 Kubota Y, et al., Structure and expression of the mouse oxytocin receptor gene. Mol Cell Endocrinol. 1996 Nov 29;124(1-2):25-32
(Latest) J:218357 Hattori T, et al., Impairment of interstrain social recognition during territorial aggressive behavior in oxytocin receptor-null mice. Neurosci Res. 2015 Jan;90:90-4
All references(50)
Other
accession IDs
MGD-MRK-38191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory