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Oxtr
Gene Detail
 Symbol
Name
ID
Oxtr
oxytocin receptor
MGI:109147
Synonyms OTR
Feature Type protein coding gene
Genetic Map
Chromosome 6
52.27 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:112473684-112489808 bp, - strand
From NCBI annotation of GRCm38

  16125 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: vasopressin/oxytocin receptor
Gene Tree: Oxtr

Human
homologs
Human Homolog OXTR, oxytocin receptor
NCBI Gene ID 5021
neXtProt AC  NX_P30559
Human Synonyms  OT-R
Human Chr (Location)  3p25; chr3:8750408-8769614 (-)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null females fail to lactate and exhibit decreased maternal behavior. Males exhibit an increase in aggression, hypoactivity and vocalization in response to social isolation, and social amnesia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process eating behavior, ERK1 and ERK2 cascade, ...
Component apical plasma membrane, cell-cell adherens junction, ...
Function G-protein coupled receptor activity, oxytocin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (22)    Tissues (10)    Images (4)
Theiler Stages: 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Northern blot 11
RT-PCR 11
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000049112 (Evidence)
Entrez Gene18430 (Evidence)
UniGene333310
DFCITC1648318
DoTSDT.101286840, DT.521543
NIA Mouse Gene IndexU067286
Consensus CDS ProjectCCDS39588.1
International Mouse Knockout Project StatusOxtr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18430 NCBI Gene Model | MGI Sequence Detail 16125 C57BL/6J ±  kb
transcript NM_001081147 RefSeq | MGI Sequence Detail 4568 Not Specified 
polypeptide P97926 UniProt | EBI | MGI Sequence Detail 388 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR002062 Oxytocin receptor
InterPro IPR001817 Vasopressin receptor
Protein Ontology PR:000001635 oxytocin receptor
Graphical View of Protein Domain Structure
References (Earliest) J:33726 Kaluz S, et al., Heterogeneity in the third intracytoplasmic region of the oxytocin receptor-encoding gene. Gene. 1996 Jun 26;172(2):313-4
(Latest) J:206098 Dolen G, et al., Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature. 2013 Sep 12;501(7466):179-84
All references(48)
Other
accession IDs
MGD-MRK-38191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory