Oxtr
Gene Detail

Symbol Name ID

Oxtr oxytocin receptor MGI:109147

Synonyms

OTR

Feature Type

protein coding gene

Genetic Map

Chromosome 6

52.27 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:112473684-112489808 bp, - strand From NCBI annotation of GRCm38   16125 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: vasopressin/oxytocin receptor
Gene Tree: Oxtr

Human homologs

Human Homolog		OXTR, oxytocin receptor
NCBI Gene ID		5021
neXtProt AC		NX_P30559
Human Synonyms		OT-R
Human Chr (Location)		3p25; chr3:8792094-8811300 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygous null females fail to lactate and exhibit decreased maternal behavior. Males exhibit an increase in aggression, hypoactivity and vocalization in response to social isolation, and social amnesia.

 

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	eating behavior, elevation of cytosolic calcium ion concentration, ...
Component	apical plasma membrane, cell-cell adherens junction, ...
Function	G-protein coupled receptor activity, oxytocin receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (22)    Tissues (10)    Images (4)
Theiler Stages: 18, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Northern blot	11
RT-PCR	11

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(2) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000049112 (Evidence)
Entrez Gene	18430 (Evidence)
UniGene	333310
DFCI	TC1648318
DoTS	DT.101286840, DT.521543
NIA Mouse Gene Index	U067286
Consensus CDS Project	CCDS39588.1
International Mouse Knockout Project Status	Oxtr

Sequences

Length	Strain/Species
genomic	18430	NCBI Gene Model | MGI Sequence Detail	16125	C57BL/6J
transcript	NM_001081147	RefSeq | MGI Sequence Detail	4568	Not Specified
polypeptide	P97926	UniProt | EBI | MGI Sequence Detail	388	Not Applicable

All sequences(20) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(136 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR002062	Oxytocin receptor
InterPro	IPR001817	Vasopressin receptor
Protein Ontology	PR:000001635	oxytocin receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:33726 Kaluz S, et al., Heterogeneity in the third intracytoplasmic region of the oxytocin receptor-encoding gene. Gene. 1996 Jun 26;172(2):313-4
(Latest) J:190242 Colaianni G, et al., Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton. J Biol Chem. 2012 Aug 17;287(34):29159-67
All references(45)

Other accession IDs

MGD-MRK-38191