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Rasgrf2 Gene Detail
Summary
  • Symbol
    Rasgrf2
  • Name
    RAS protein-specific guanine nucleotide-releasing factor 2
  • Synonyms
    6330417G04Rik, Grf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109137
    NCBI Gene: 19418
  • Gene Overview
    MyGene.info: RASGRF2
Location & Maps
more
  • Sequence Map
    Chr13:91880400-92131656 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      251257 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.43 cM, cytoband C3-D1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RASGRF2, Ras protein specific guanine nucleotide releasing factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RASGRF2, Ras protein specific guanine nucleotide releasing factor 2
    Orthology source: HomoloGene
  • Synonyms
    GRF2, RAS-GRF2
  • Links
    NCBI Gene ID: 5924
    neXtProt AC: NX_O14827

  • Chr Location
    5q13; chr5:80960672-81230162 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Rasgrf2
  • Incidental Mutations
Mice homozygous for a targeted null mutation exhibit decreased Il2 and TNF-alpha production in stimulated T cells. Mice homozygous for mutations in both Rasgrf1 and Rasgrf2 exhibit no additional abnormalities than those observed in the Rasgrf1 mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034142 VEGA Gene Model | MGI Sequence Detail 251257 C57BL/6J ±  kb
transcript OTTMUST00000086461 VEGA | MGI Sequence Detail 5797 Not Applicable  
polypeptide OTTMUSP00000046827 VEGA | MGI Sequence Detail 588 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1236 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013757 ras-specific guanine nucleotide-releasing factor 2
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR000048 IQ motif, EF-hand binding site
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR019804 Ras guanine-nucleotide exchange factor, conserved site
    IPR023578 Ras guanine nucleotide exchange factor domain
    IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
    IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    IPR030744 Ras-specific guanine nucleotide-releasing factor 2
Molecular
Reagents
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  • All nucleic 22
    Genomic 1
    cDNA 20
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-38181, MGI:1917989, MGI:2145404
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:38724 Chen L, et al., A murine CDC25/ras-GRF-related protein implicated in Ras regulation. Dev Genet. 1993;14(5):339-46
  • Latest
    J:220523 Harris JA, et al., Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits. 2014;8:76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory